Paper abstract bibtex

Time dependence is a universal phenomenon in nature, and a variety of mathematical models in terms of dynamical systems have been developed to understand the time-dependent behavior of real-world problems. Originally constructed to analyze the topological persistence over spatial scales, persistent homology has rarely been devised for time evolution. We propose the use of a new filtration function for persistent homology which takes as input the adjacent oscillator trajectories of a dynamical system. We also regulate the dynamical system by a weighted graph Laplacian matrix derived from the network of interest, which embeds the topological connectivity of the network into the dynamical system. The resulting topological signatures, which we call evolutionary homology (EH) barcodes, reveal the topology-function relationship of the network and thus give rise to the quantitative analysis of nodal properties. The proposed EH is applied to protein residue networks for protein thermal fluctuation analysis, rendering the most accurate B-factor prediction of a set of 364 proteins. This work extends the utility of dynamical systems to the quantitative modeling and analysis of realistic physical systems.

@article{cangEvolutionaryHomologyCoupled2018, archivePrefix = {arXiv}, eprinttype = {arxiv}, eprint = {1802.04677}, primaryClass = {math, q-bio}, title = {Evolutionary Homology on Coupled Dynamical Systems}, url = {http://arxiv.org/abs/1802.04677}, abstract = {Time dependence is a universal phenomenon in nature, and a variety of mathematical models in terms of dynamical systems have been developed to understand the time-dependent behavior of real-world problems. Originally constructed to analyze the topological persistence over spatial scales, persistent homology has rarely been devised for time evolution. We propose the use of a new filtration function for persistent homology which takes as input the adjacent oscillator trajectories of a dynamical system. We also regulate the dynamical system by a weighted graph Laplacian matrix derived from the network of interest, which embeds the topological connectivity of the network into the dynamical system. The resulting topological signatures, which we call evolutionary homology (EH) barcodes, reveal the topology-function relationship of the network and thus give rise to the quantitative analysis of nodal properties. The proposed EH is applied to protein residue networks for protein thermal fluctuation analysis, rendering the most accurate B-factor prediction of a set of 364 proteins. This work extends the utility of dynamical systems to the quantitative modeling and analysis of realistic physical systems.}, urldate = {2018-04-05}, date = {2018-02-13}, keywords = {Mathematics - Algebraic Topology,Mathematics - Dynamical Systems,Quantitative Biology - Quantitative Methods}, author = {Cang, Zixuan and Munch, Elizabeth and Wei, Guo-Wei}, file = {/home/dimitri/Nextcloud/Zotero/storage/4TZC2U2K/Cang et al. - 2018 - Evolutionary homology on coupled dynamical systems.pdf;/home/dimitri/Nextcloud/Zotero/storage/6RNFZZ93/Cang et al. - 2018 - Evolutionary homology on coupled dynamical systems.pdf;/home/dimitri/Nextcloud/Zotero/storage/984CQS7D/1802.html;/home/dimitri/Nextcloud/Zotero/storage/IR4MU62L/1802.html} }

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