@article{RN257,
   author = {Canjels, L. P. W. and Backes, W. H. and van Veenendaal, T. M. and Vlooswijk, M. C. G. and Hofman, P. A. M. and Aldenkamp, A. P. and Rouhl, R. P. W. and Jansen, J. F. A.},
   title = {Volumetric and Functional Activity Lateralization in Healthy Subjects and Patients with Focal Epilepsy: Initial Findings in a 7T MRI Study},
   journal = {J Neuroimaging},
   note = {Canjels, Lisanne P W
Backes, Walter H
van Veenendaal, Tamar M
Vlooswijk, Marielle C G
Hofman, Paul A M
Aldenkamp, Albert P
Rouhl, Rob P W
Jansen, Jacobus F A
eng
S.2014.14/the University Fund Limburg/SWOL
S.2014.14/University Fund Limburg/SWOL
2020/05/31 06:00
J Neuroimaging. 2020 May 30. doi: 10.1111/jon.12739.},
   abstract = {BACKGROUND AND PURPOSE: In 30% of the patients with focal epilepsy, an epileptogenic lesion cannot be visually detected with structural MRI. Ultra-high field MRI may be able to identify subtle pathology related to the epileptic focus. We set out to assess 7T MRI-derived volumetric and functional activity lateralization of the hippocampus, hippocampal subfields, temporal and frontal lobe in healthy subjects and MRI-negative patients with focal epilepsy. METHODS: Twenty controls and 10 patients with MRI-negative temporal or frontal lobe epilepsy (TLE and FLE, respectively) underwent a 7T MRI exam. T1 -weigthed imaging and resting-state fMRI was performed. T1 -weighted images were segmented to yield volumes, while from fMRI data, the fractional amplitude of low frequency fluctuations was calculated. Subsequently, volumetric and functional lateralization was calculated from left-right asymmetry. RESULTS: In controls, volumetric lateralization was symmetric, with a slight asymmetry of the hippocampus and subiculum, while functional lateralization consistently showed symmetry. Contrarily, in epilepsy patients, regions were less symmetric. In TLE patients with known focus, volumetric lateralization in the hippocampus and hippocampal subfields was indicative of smaller ipsilateral volumes. These patients also showed clear functional lateralization, though not consistently ipsilateral or contralateral to the epileptic focus. TLE patients with unknown focus showed an obvious volumetric lateralization, facilitating the localization of the epileptic focus. Lateralization results in the FLE patients were less consistent with the epileptic focus. CONCLUSION: MRI-derived volume and fluctuation amplitude are highly symmetric in controls, whereas in TLE, volumetric and functional lateralization effects were observed. This highlights the potential of the technique.},
   keywords = {7t
fMRI
hippocampus
lateralization
volumes},
   ISSN = {1552-6569 (Electronic)
1051-2284 (Linking)},
   DOI = {10.1111/jon.12739},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/32472965
https://onlinelibrary.wiley.com/doi/full/10.1111/jon.12739},
   year = {2020},
   type = {Journal Article}
}

{"_id":"caG4wiex2ktvTkMcS","bibbaseid":"canjels-backes-vanveenendaal-vlooswijk-hofman-aldenkamp-rouhl-jansen-volumetricandfunctionalactivitylateralizationinhealthysubjectsandpatientswithfocalepilepsyinitialfindingsina7tmristudy-2020","authorIDs":["DoNKbgB55xkR6SehT","NAFTFJTb9GJgC2h6i","TEAWLnKpXtQE8hs6C","hShritfXo7Lzr2RkJ"],"author_short":["Canjels, L. P. W.","Backes, W. H.","van Veenendaal, T. M.","Vlooswijk, M. C. G.","Hofman, P. A. M.","Aldenkamp, A. P.","Rouhl, R. P. W.","Jansen, J. F. A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Canjels"],"firstnames":["L.","P.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":["van"],"lastnames":["Veenendaal"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Vlooswijk"],"firstnames":["M.","C.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Rouhl"],"firstnames":["R.","P.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]}],"title":"Volumetric and Functional Activity Lateralization in Healthy Subjects and Patients with Focal Epilepsy: Initial Findings in a 7T MRI Study","journal":"J Neuroimaging","note":"Canjels, Lisanne P W Backes, Walter H van Veenendaal, Tamar M Vlooswijk, Marielle C G Hofman, Paul A M Aldenkamp, Albert P Rouhl, Rob P W Jansen, Jacobus F A eng S.2014.14/the University Fund Limburg/SWOL S.2014.14/University Fund Limburg/SWOL 2020/05/31 06:00 J Neuroimaging. 2020 May 30. doi: 10.1111/jon.12739.","abstract":"BACKGROUND AND PURPOSE: In 30% of the patients with focal epilepsy, an epileptogenic lesion cannot be visually detected with structural MRI. Ultra-high field MRI may be able to identify subtle pathology related to the epileptic focus. We set out to assess 7T MRI-derived volumetric and functional activity lateralization of the hippocampus, hippocampal subfields, temporal and frontal lobe in healthy subjects and MRI-negative patients with focal epilepsy. METHODS: Twenty controls and 10 patients with MRI-negative temporal or frontal lobe epilepsy (TLE and FLE, respectively) underwent a 7T MRI exam. T1 -weigthed imaging and resting-state fMRI was performed. T1 -weighted images were segmented to yield volumes, while from fMRI data, the fractional amplitude of low frequency fluctuations was calculated. Subsequently, volumetric and functional lateralization was calculated from left-right asymmetry. RESULTS: In controls, volumetric lateralization was symmetric, with a slight asymmetry of the hippocampus and subiculum, while functional lateralization consistently showed symmetry. Contrarily, in epilepsy patients, regions were less symmetric. In TLE patients with known focus, volumetric lateralization in the hippocampus and hippocampal subfields was indicative of smaller ipsilateral volumes. These patients also showed clear functional lateralization, though not consistently ipsilateral or contralateral to the epileptic focus. TLE patients with unknown focus showed an obvious volumetric lateralization, facilitating the localization of the epileptic focus. Lateralization results in the FLE patients were less consistent with the epileptic focus. CONCLUSION: MRI-derived volume and fluctuation amplitude are highly symmetric in controls, whereas in TLE, volumetric and functional lateralization effects were observed. This highlights the potential of the technique.","keywords":"7t fMRI hippocampus lateralization volumes","issn":"1552-6569 (Electronic) 1051-2284 (Linking)","doi":"10.1111/jon.12739","url":"http://www.ncbi.nlm.nih.gov/pubmed/32472965 https://onlinelibrary.wiley.com/doi/full/10.1111/jon.12739","year":"2020","bibtex":"@article{RN257,\n author = {Canjels, L. P. W. and Backes, W. H. and van Veenendaal, T. M. and Vlooswijk, M. C. G. and Hofman, P. A. M. and Aldenkamp, A. P. and Rouhl, R. P. W. and Jansen, J. F. A.},\n title = {Volumetric and Functional Activity Lateralization in Healthy Subjects and Patients with Focal Epilepsy: Initial Findings in a 7T MRI Study},\n journal = {J Neuroimaging},\n note = {Canjels, Lisanne P W\nBackes, Walter H\nvan Veenendaal, Tamar M\nVlooswijk, Marielle C G\nHofman, Paul A M\nAldenkamp, Albert P\nRouhl, Rob P W\nJansen, Jacobus F A\neng\nS.2014.14/the University Fund Limburg/SWOL\nS.2014.14/University Fund Limburg/SWOL\n2020/05/31 06:00\nJ Neuroimaging. 2020 May 30. doi: 10.1111/jon.12739.},\n abstract = {BACKGROUND AND PURPOSE: In 30% of the patients with focal epilepsy, an epileptogenic lesion cannot be visually detected with structural MRI. Ultra-high field MRI may be able to identify subtle pathology related to the epileptic focus. We set out to assess 7T MRI-derived volumetric and functional activity lateralization of the hippocampus, hippocampal subfields, temporal and frontal lobe in healthy subjects and MRI-negative patients with focal epilepsy. METHODS: Twenty controls and 10 patients with MRI-negative temporal or frontal lobe epilepsy (TLE and FLE, respectively) underwent a 7T MRI exam. T1 -weigthed imaging and resting-state fMRI was performed. T1 -weighted images were segmented to yield volumes, while from fMRI data, the fractional amplitude of low frequency fluctuations was calculated. Subsequently, volumetric and functional lateralization was calculated from left-right asymmetry. RESULTS: In controls, volumetric lateralization was symmetric, with a slight asymmetry of the hippocampus and subiculum, while functional lateralization consistently showed symmetry. Contrarily, in epilepsy patients, regions were less symmetric. In TLE patients with known focus, volumetric lateralization in the hippocampus and hippocampal subfields was indicative of smaller ipsilateral volumes. These patients also showed clear functional lateralization, though not consistently ipsilateral or contralateral to the epileptic focus. TLE patients with unknown focus showed an obvious volumetric lateralization, facilitating the localization of the epileptic focus. Lateralization results in the FLE patients were less consistent with the epileptic focus. CONCLUSION: MRI-derived volume and fluctuation amplitude are highly symmetric in controls, whereas in TLE, volumetric and functional lateralization effects were observed. This highlights the potential of the technique.},\n keywords = {7t\nfMRI\nhippocampus\nlateralization\nvolumes},\n ISSN = {1552-6569 (Electronic)\n1051-2284 (Linking)},\n DOI = {10.1111/jon.12739},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/32472965\nhttps://onlinelibrary.wiley.com/doi/full/10.1111/jon.12739},\n year = {2020},\n type = {Journal Article}\n}\n\n","author_short":["Canjels, L. P. W.","Backes, W. H.","van Veenendaal, T. M.","Vlooswijk, M. C. G.","Hofman, P. A. M.","Aldenkamp, A. P.","Rouhl, R. P. W.","Jansen, J. F. 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