@article{RN301,
   author = {Canjels, L. P. W. and Jansen, J. F. A. and Alers, R. J. and Ghossein-Doha, C. and van den Kerkhof, M. and Schiffer, Vmmm and Mulder, E. and Gerretsen, S. C. and Aldenkamp, A. P. and Hurks, P. P. M. and van de Ven, V. and Spaanderman, M. E. A. and Backes, W. H.},
   title = {Blood-brain barrier leakage years after pre-eclampsia: dynamic contrast-enhanced 7-Tesla MRI study},
   journal = {Ultrasound Obstet Gynecol},
   note = {Canjels, L P W
Jansen, J F A
Alers, R-J
Ghossein-Doha, C
van den Kerkhof, M
Schiffer, V M M M
Mulder, E
Gerretsen, S C
Aldenkamp, A P
Hurks, P P M
van de Ven, V
Spaanderman, M E A
Backes, W H
eng
England
Ultrasound Obstet Gynecol. 2022 May 2. doi: 10.1002/uog.24930.},
   abstract = {OBJECTIVE: Preeclampsia, a hypertensive complication of pregnancy, relates to an increased risk of long-term cardiovascular and cerebrovascular disorders. Although the persisting susceptibility to cerebral complications after preeclampsia remains largely unclear, impaired blood-brain barrier (BBB) integrity is often proposed to precede several cerebrovascular diseases. Therefore, we investigated the integrity of the BBB years after preeclampsia. METHODS: We performed cerebral magnetic resonance imaging (MRI) at ultra-high field (7 Tesla) in 22 formerly preeclamptic women (aged 37.8 +/- 5.4 years, postpartum time 6.6 +/- 3.2 years) and 13 control women with normotensive pregnancies (aged 40.8 +/- 5.5 years, postpartum time 9.0 +/- 3.7 years) to assess the integrity of the blood-brain barrier. Permeability of the blood-brain barrier was determined by assessing leakage rate and fractional leakage volume of a gadolinium-based contrast agent, measured by dynamic contrast-enhanced MRI. Blood-brain barrier leakage measures were determined for the whole brain and lobular white and gray matter. Multivariable analyses were performed and odd's ratios were calculated to compare women with and without preeclampsia, adjusted for potentially confounding effects of age, current hypertension status and Fazekas score. RESULTS: Leakage rate and fractional leakage volume were significantly higher in formerly preeclamptic women compared to control women in the global white (p = 0.001) and gray matter (p = 0.02). Regionally, the frontal (p = 0.04) and parietal cortical gray matter (p = 0.009), and the frontal (p = 0.001), temporal (p = 0.05) and occipital white matter (p = 0.007) showed higher leakage measures in formerly preeclamptic women. The odds of a high leakage rate after preeclampsia were generally higher in white matter regions compared to gray matter regions. CONCLUSION: This observational study shows a globally impaired blood-brain barrier years after a preeclamptic pregnancy, which could be an early marker for long-term cerebrovascular disorders. This article is protected by copyright. All rights reserved.},
   keywords = {7 Tesla
blood-brain barrier
cerebrovascular disorder
dynamic contrast-enhanced MRI
preeclampsia},
   ISSN = {1469-0705 (Electronic)
0960-7692 (Linking)},
   DOI = {10.1002/uog.24930},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/35502137},
   year = {2022},
   type = {Journal Article}
}

{"_id":"QHKM5647R9X66dbi9","bibbaseid":"canjels-jansen-alers-ghosseindoha-vandenkerkhof-schiffer-mulder-gerretsen-etal-bloodbrainbarrierleakageyearsafterpreeclampsiadynamiccontrastenhanced7teslamristudy-2022","author_short":["Canjels, L. P. W.","Jansen, J. F. A.","Alers, R. J.","Ghossein-Doha, C.","van den Kerkhof, M.","Schiffer, V.","Mulder, E.","Gerretsen, S. C.","Aldenkamp, A. P.","Hurks, P. P. M.","van de Ven, V.","Spaanderman, M. E. A.","Backes, W. H."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Canjels"],"firstnames":["L.","P.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Alers"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Ghossein-Doha"],"firstnames":["C."],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Kerkhof"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Schiffer"],"firstnames":["Vmmm"],"suffixes":[]},{"propositions":[],"lastnames":["Mulder"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Gerretsen"],"firstnames":["S.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Hurks"],"firstnames":["P.","P.","M."],"suffixes":[]},{"propositions":["van","de"],"lastnames":["Ven"],"firstnames":["V."],"suffixes":[]},{"propositions":[],"lastnames":["Spaanderman"],"firstnames":["M.","E.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Blood-brain barrier leakage years after pre-eclampsia: dynamic contrast-enhanced 7-Tesla MRI study","journal":"Ultrasound Obstet Gynecol","note":"Canjels, L P W Jansen, J F A Alers, R-J Ghossein-Doha, C van den Kerkhof, M Schiffer, V M M M Mulder, E Gerretsen, S C Aldenkamp, A P Hurks, P P M van de Ven, V Spaanderman, M E A Backes, W H eng England Ultrasound Obstet Gynecol. 2022 May 2. doi: 10.1002/uog.24930.","abstract":"OBJECTIVE: Preeclampsia, a hypertensive complication of pregnancy, relates to an increased risk of long-term cardiovascular and cerebrovascular disorders. Although the persisting susceptibility to cerebral complications after preeclampsia remains largely unclear, impaired blood-brain barrier (BBB) integrity is often proposed to precede several cerebrovascular diseases. Therefore, we investigated the integrity of the BBB years after preeclampsia. METHODS: We performed cerebral magnetic resonance imaging (MRI) at ultra-high field (7 Tesla) in 22 formerly preeclamptic women (aged 37.8 +/- 5.4 years, postpartum time 6.6 +/- 3.2 years) and 13 control women with normotensive pregnancies (aged 40.8 +/- 5.5 years, postpartum time 9.0 +/- 3.7 years) to assess the integrity of the blood-brain barrier. Permeability of the blood-brain barrier was determined by assessing leakage rate and fractional leakage volume of a gadolinium-based contrast agent, measured by dynamic contrast-enhanced MRI. Blood-brain barrier leakage measures were determined for the whole brain and lobular white and gray matter. Multivariable analyses were performed and odd's ratios were calculated to compare women with and without preeclampsia, adjusted for potentially confounding effects of age, current hypertension status and Fazekas score. RESULTS: Leakage rate and fractional leakage volume were significantly higher in formerly preeclamptic women compared to control women in the global white (p = 0.001) and gray matter (p = 0.02). Regionally, the frontal (p = 0.04) and parietal cortical gray matter (p = 0.009), and the frontal (p = 0.001), temporal (p = 0.05) and occipital white matter (p = 0.007) showed higher leakage measures in formerly preeclamptic women. The odds of a high leakage rate after preeclampsia were generally higher in white matter regions compared to gray matter regions. CONCLUSION: This observational study shows a globally impaired blood-brain barrier years after a preeclamptic pregnancy, which could be an early marker for long-term cerebrovascular disorders. This article is protected by copyright. All rights reserved.","keywords":"7 Tesla blood-brain barrier cerebrovascular disorder dynamic contrast-enhanced MRI preeclampsia","issn":"1469-0705 (Electronic) 0960-7692 (Linking)","doi":"10.1002/uog.24930","url":"https://www.ncbi.nlm.nih.gov/pubmed/35502137","year":"2022","bibtex":"@article{RN301,\n author = {Canjels, L. P. W. and Jansen, J. F. A. and Alers, R. J. and Ghossein-Doha, C. and van den Kerkhof, M. and Schiffer, Vmmm and Mulder, E. and Gerretsen, S. C. and Aldenkamp, A. P. and Hurks, P. P. M. and van de Ven, V. and Spaanderman, M. E. A. and Backes, W. H.},\n title = {Blood-brain barrier leakage years after pre-eclampsia: dynamic contrast-enhanced 7-Tesla MRI study},\n journal = {Ultrasound Obstet Gynecol},\n note = {Canjels, L P W\nJansen, J F A\nAlers, R-J\nGhossein-Doha, C\nvan den Kerkhof, M\nSchiffer, V M M M\nMulder, E\nGerretsen, S C\nAldenkamp, A P\nHurks, P P M\nvan de Ven, V\nSpaanderman, M E A\nBackes, W H\neng\nEngland\nUltrasound Obstet Gynecol. 2022 May 2. doi: 10.1002/uog.24930.},\n abstract = {OBJECTIVE: Preeclampsia, a hypertensive complication of pregnancy, relates to an increased risk of long-term cardiovascular and cerebrovascular disorders. Although the persisting susceptibility to cerebral complications after preeclampsia remains largely unclear, impaired blood-brain barrier (BBB) integrity is often proposed to precede several cerebrovascular diseases. Therefore, we investigated the integrity of the BBB years after preeclampsia. METHODS: We performed cerebral magnetic resonance imaging (MRI) at ultra-high field (7 Tesla) in 22 formerly preeclamptic women (aged 37.8 +/- 5.4 years, postpartum time 6.6 +/- 3.2 years) and 13 control women with normotensive pregnancies (aged 40.8 +/- 5.5 years, postpartum time 9.0 +/- 3.7 years) to assess the integrity of the blood-brain barrier. Permeability of the blood-brain barrier was determined by assessing leakage rate and fractional leakage volume of a gadolinium-based contrast agent, measured by dynamic contrast-enhanced MRI. Blood-brain barrier leakage measures were determined for the whole brain and lobular white and gray matter. Multivariable analyses were performed and odd's ratios were calculated to compare women with and without preeclampsia, adjusted for potentially confounding effects of age, current hypertension status and Fazekas score. RESULTS: Leakage rate and fractional leakage volume were significantly higher in formerly preeclamptic women compared to control women in the global white (p = 0.001) and gray matter (p = 0.02). Regionally, the frontal (p = 0.04) and parietal cortical gray matter (p = 0.009), and the frontal (p = 0.001), temporal (p = 0.05) and occipital white matter (p = 0.007) showed higher leakage measures in formerly preeclamptic women. The odds of a high leakage rate after preeclampsia were generally higher in white matter regions compared to gray matter regions. CONCLUSION: This observational study shows a globally impaired blood-brain barrier years after a preeclamptic pregnancy, which could be an early marker for long-term cerebrovascular disorders. This article is protected by copyright. All rights reserved.},\n keywords = {7 Tesla\nblood-brain barrier\ncerebrovascular disorder\ndynamic contrast-enhanced MRI\npreeclampsia},\n ISSN = {1469-0705 (Electronic)\n0960-7692 (Linking)},\n DOI = {10.1002/uog.24930},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/35502137},\n year = {2022},\n type = {Journal Article}\n}\n\n","author_short":["Canjels, L. P. W.","Jansen, J. F. A.","Alers, R. J.","Ghossein-Doha, C.","van den Kerkhof, M.","Schiffer, V.","Mulder, E.","Gerretsen, S. C.","Aldenkamp, A. P.","Hurks, P. P. M.","van de Ven, V.","Spaanderman, M. E. A.","Backes, W. H."],"key":"RN301","id":"RN301","bibbaseid":"canjels-jansen-alers-ghosseindoha-vandenkerkhof-schiffer-mulder-gerretsen-etal-bloodbrainbarrierleakageyearsafterpreeclampsiadynamiccontrastenhanced7teslamristudy-2022","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/35502137"},"keyword":["7 Tesla blood-brain barrier cerebrovascular disorder dynamic contrast-enhanced MRI preeclampsia"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":["7 tesla blood-brain barrier cerebrovascular disorder dynamic contrast-enhanced mri preeclampsia"],"search_terms":["blood","brain","barrier","leakage","years","pre","eclampsia","dynamic","contrast","enhanced","tesla","mri","study","canjels","jansen","alers","ghossein-doha","van den kerkhof","schiffer","mulder","gerretsen","aldenkamp","hurks","van de ven","spaanderman","backes"],"title":"Blood-brain barrier leakage years after pre-eclampsia: dynamic contrast-enhanced 7-Tesla MRI study","year":2022}