Mapping cortical and subcortical asymmetries in substance dependence: \Findings\ from the \ENIGMA\ \Addiction\ \Working\ \Group\. Cao, Z., Ottino‐Gonzalez, J., Cupertino, R. B, Schwab, N., Hoke, C., Catherine, O., Cousijn, J., Dagher, A., Foxe, J. J, Goudriaan, A. E, Hester, R., Hutchison, K., Li, C. R, London, E. D, Lorenzetti, V., Luijten, M., Martin‐Santos, R., Momenan, R., Paulus, M. P, Schmaal, L., Sinha, R., Sjoerds, Z., Solowij, N., Stein, D. J, Stein, E. A, Uhlmann, A., Van Holst, R. J, Veltman, D. J, Wiers, R. W, Yücel, M., Zhang, S., Jahanshad, N., Thompson, P. M, Conrod, P., Mackey, S., & Garavan, H. Addiction Biology, 26(5):e13010, sep, 2021. ![Mapping cortical and subcortical asymmetries in substance dependence: \Findings\ from the \ENIGMA\ \Addiction\ \Working\ \Group\ [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Abstract Brain asymmetry reflects left‐right hemispheric differentiation, which is a quantitative brain phenotype that develops with age and can vary with psychiatric diagnoses. Previous studies have shown that substance dependence is associated with altered brain structure and function. However, it is unknown whether structural brain asymmetries are different in individuals with substance dependence compared with nondependent participants. Here, a mega‐analysis was performed using a collection of 22 structural brain MRI datasets from the ENIGMA Addiction Working Group. Structural asymmetries of cortical and subcortical regions were compared between individuals who were dependent on alcohol, nicotine, cocaine, methamphetamine, or cannabis ( n = 1,796) and nondependent participants ( n = 996). Substance‐general and substance‐specific effects on structural asymmetry were examined using separate models. We found that substance dependence was significantly associated with differences in volume asymmetry of the nucleus accumbens (NAcc; less rightward; Cohen's d = 0.15). This effect was driven by differences from controls in individuals with alcohol dependence (less rightward; Cohen's d = 0.10) and nicotine dependence (less rightward; Cohen's d = 0.11). These findings suggest that disrupted structural asymmetry in the NAcc may be a characteristic of substance dependence.
@article{cao_mapping_2021,
abstract = {Abstract
Brain asymmetry reflects left‐right hemispheric differentiation, which is a quantitative brain phenotype that develops with age and can vary with psychiatric diagnoses. Previous studies have shown that substance dependence is associated with altered brain structure and function. However, it is unknown whether structural brain asymmetries are different in individuals with substance dependence compared with nondependent participants. Here, a mega‐analysis was performed using a collection of 22 structural brain MRI datasets from the ENIGMA Addiction Working Group. Structural asymmetries of cortical and subcortical regions were compared between individuals who were dependent on alcohol, nicotine, cocaine, methamphetamine, or cannabis (
n
= 1,796) and nondependent participants (
n
= 996). Substance‐general and substance‐specific effects on structural asymmetry were examined using separate models. We found that substance dependence was significantly associated with differences in volume asymmetry of the nucleus accumbens (NAcc; less rightward; Cohen's
d
= 0.15). This effect was driven by differences from controls in individuals with alcohol dependence (less rightward; Cohen's
d
= 0.10) and nicotine dependence (less rightward; Cohen's
d
= 0.11). These findings suggest that disrupted structural asymmetry in the NAcc may be a characteristic of substance dependence.},
author = {Cao, Zhipeng and Ottino‐Gonzalez, Jonatan and Cupertino, Renata B and Schwab, Nathan and Hoke, Colin and Catherine, Orr and Cousijn, Janna and Dagher, Alain and Foxe, John J and Goudriaan, Anna E and Hester, Robert and Hutchison, Kent and Li, Chiang‐Shan R and London, Edythe D and Lorenzetti, Valentina and Luijten, Maartje and Martin‐Santos, Rocio and Momenan, Reza and Paulus, Martin P and Schmaal, Lianne and Sinha, Rajita and Sjoerds, Zsuzsika and Solowij, Nadia and Stein, Dan J and Stein, Elliot A and Uhlmann, Anne and {Van Holst}, Ruth J and Veltman, Dick J and Wiers, Reinout W and Y{\"{u}}cel, Murat and Zhang, Sheng and Jahanshad, Neda and Thompson, Paul M and Conrod, Patricia and Mackey, Scott and Garavan, Hugh},
doi = {10.1111/adb.13010},
file = {:Users/jacquelinebracher/Zotero/storage/QXAFJL8L/Cao et al. - 2021 - Mapping cortical and subcortical asymmetries in su.pdf:pdf},
issn = {1355-6215, 1369-1600},
journal = {Addiction Biology},
month = {sep},
number = {5},
pages = {e13010},
shorttitle = {Mapping cortical and subcortical asymmetries in su},
title = {{Mapping cortical and subcortical asymmetries in substance dependence: {\{}Findings{\}} from the {\{}ENIGMA{\}} {\{}Addiction{\}} {\{}Working{\}} {\{}Group{\}}}},
url = {https://onlinelibrary.wiley.com/doi/10.1111/adb.13010},
volume = {26},
year = {2021}
}
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