Efficient T2 mapping with blip-up/down EPI and gSlider-SMS (T2 -BUDA-gSlider). Cao, X., Wang, K., Liao, C., Zhang, Z., Srinivasan Iyer, S., Chen, Z., Lo, W., Liu, H., He, H., Setsompop, K., Zhong, J., & Bilgic, B. Magnetic Resonance in Medicine, 86(4):2064–2075, October, 2021.
doi  abstract   bibtex   
PURPOSE: To rapidly obtain high isotropic-resolution T2 maps with whole-brain coverage and high geometric fidelity. METHODS: A T2 blip-up/down EPI acquisition with generalized slice-dithered enhanced resolution (T2 -BUDA-gSlider) is proposed. A RF-encoded multi-slab spin-echo (SE) EPI acquisition with multiple TEs was developed to obtain high SNR efficiency with reduced TR. This was combined with an interleaved 2-shot EPI acquisition using blip-up/down phase encoding. An estimated field map was incorporated into the joint multi-shot EPI reconstruction with a structured low rank constraint to achieve distortion-free and robust reconstruction for each slab without navigation. A Bloch simulated subspace model was integrated into gSlider reconstruction and used for T2 quantification. RESULTS: In vivo results demonstrated that the T2 values estimated by the proposed method were consistent with gold standard spin-echo acquisition. Compared to the reference 3D fast spin echo (FSE) images, distortion caused by off-resonance and eddy current effects were effectively mitigated. CONCLUSION: BUDA-gSlider SE-EPI acquisition and gSlider-subspace joint reconstruction enabled distortion-free whole-brain T2 mapping in 2 min at ~1 mm3 isotropic resolution, which could bring significant benefits to related clinical and neuroscience applications.
@article{cao_efficient_2021,
	title = {Efficient {T2} mapping with blip-up/down {EPI} and {gSlider}-{SMS} ({T2} -{BUDA}-{gSlider})},
	volume = {86},
	issn = {1522-2594},
	doi = {10.1002/mrm.28872},
	abstract = {PURPOSE: To rapidly obtain high isotropic-resolution T2 maps with whole-brain coverage and high geometric fidelity.
METHODS: A T2 blip-up/down EPI acquisition with generalized slice-dithered enhanced resolution (T2 -BUDA-gSlider) is proposed. A RF-encoded multi-slab spin-echo (SE) EPI acquisition with multiple TEs was developed to obtain high SNR efficiency with reduced TR. This was combined with an interleaved 2-shot EPI acquisition using blip-up/down phase encoding. An estimated field map was incorporated into the joint multi-shot EPI reconstruction with a structured low rank constraint to achieve distortion-free and robust reconstruction for each slab without navigation. A Bloch simulated subspace model was integrated into gSlider reconstruction and used for T2 quantification.
RESULTS: In vivo results demonstrated that the T2 values estimated by the proposed method were consistent with gold standard spin-echo acquisition. Compared to the reference 3D fast spin echo (FSE) images, distortion caused by off-resonance and eddy current effects were effectively mitigated.
CONCLUSION: BUDA-gSlider SE-EPI acquisition and gSlider-subspace joint reconstruction enabled distortion-free whole-brain T2 mapping in 2 min at {\textasciitilde}1 mm3 isotropic resolution, which could bring significant benefits to related clinical and neuroscience applications.},
	language = {eng},
	number = {4},
	journal = {Magnetic Resonance in Medicine},
	author = {Cao, Xiaozhi and Wang, Kang and Liao, Congyu and Zhang, Zijing and Srinivasan Iyer, Siddharth and Chen, Zhifeng and Lo, Wei-Ching and Liu, Huafeng and He, Hongjian and Setsompop, Kawin and Zhong, Jianhui and Bilgic, Berkin},
	month = oct,
	year = {2021},
	pmid = {34046924},
	pmcid = {PMC8295207},
	keywords = {BUDA, Brain, Brain Mapping, Echo-Planar Imaging, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, T2 map, gSlider, structured low rank},
	pages = {2064--2075},
}

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