Computation of the Redox and Protonation Properties of Quinones: Towards the Prediction of Redox Cycling Natural Products. Cape, J. L, Bowman, M. K, & Kramer, D. M Phytochemistry, 67(16):1781--1788, Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6314, USA., 2006. ![Computation of the Redox and Protonation Properties of Quinones: Towards the Prediction of Redox Cycling Natural Products. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Quinone metabolites perform a variety of key functions in plants, including pathogen protection, oxidative phosphorylation, and redox signaling. Many of these structurally diverse compounds have been shown to exhibit potent antimicrobial, anticancer, and anti-inflammatory properties, although the exact mechanisms of action are far from understood. Redox cycling has been proposed as a possible mechanism of action for many quinone species. Experimental determination of the essential thermodynamic data (i.e. electrochemical and pKa values) required to predict the propensity towards redox cycling is often difficult or impossible to obtain due to experimental limitations. We demonstrate a practical computational approach to obtain reasonable estimates of these parameters.
@article{Cape:2006aa,
Abstract = {Quinone metabolites perform a variety of key functions in plants, including pathogen protection, oxidative phosphorylation, and redox signaling. Many of these structurally diverse compounds have been shown to exhibit potent antimicrobial, anticancer, and anti-inflammatory properties, although the exact mechanisms of action are far from understood. Redox cycling has been proposed as a possible mechanism of action for many quinone species. Experimental determination of the essential thermodynamic data (i.e. electrochemical and pKa values) required to predict the propensity towards redox cycling is often difficult or impossible to obtain due to experimental limitations. We demonstrate a practical computational approach to obtain reasonable estimates of these parameters.},
Address = {Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6314, USA.},
Au = {Cape, JL and Bowman, MK and Kramer, DM},
Author = {Cape, Jonathan L and Bowman, Michael K and Kramer, David M},
Da = {20060825},
Date-Added = {2007-12-11 17:01:03 -0500},
Date-Modified = {2008-11-29 20:29:44 -0500},
Dcom = {20061026},
Dep = {20060726},
Doi = {10.1016/j.phytochem.2006.06.015},
Edat = {2006/07/29 09:00},
Gr = {GM61904/GM/NIGMS},
Issn = {0031-9422 (Print)},
Jid = {0151434},
Journal = {Phytochemistry},
Jt = {Phytochemistry},
Keywords = {redox cycling},
Language = {eng},
Local-Url = {file://localhost/Users/rguha/Documents/articles/redox-cycling.pdf},
Lr = {20061115},
Mhda = {2006/10/27 09:00},
Number = {16},
Own = {NLM},
Pages = {1781--1788},
Phst = {2006/03/06 {$[$}received{$]$}; 2006/06/09 {$[$}revised{$]$}; 2006/06/13 {$[$}accepted{$]$}; 2006/07/26 {$[$}aheadofprint{$]$}},
Pii = {S0031-9422(06)00348-7},
Pl = {United States},
Pmid = {16872647},
Pst = {ppublish},
Pt = {Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.},
Pubm = {Print-Electronic},
Rn = {0 (Biological Products); 0 (Protons); 0 (Quinones)},
Sb = {IM},
So = {Phytochemistry. 2006 Aug;67(16):1781-8. Epub 2006 Jul 26.},
Stat = {MEDLINE},
Title = {Computation of the Redox and Protonation Properties of Quinones: Towards the Prediction of Redox Cycling Natural Products.},
Url = {http://dx.doi.org/10.1016/j.phytochem.2006.06.015},
Volume = {67},
Year = {2006},
Bdsk-File-1 = {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},
Bdsk-Url-1 = {http://dx.doi.org/10.1016/j.phytochem.2006.06.015},
Bdsk-Url-2 = {http://dx.doi.org/10.1016/j.phytochem.2006.06.015}}
Downloads: 0
{"_id":"Y4XnS8X8XzJ4sxoMX","bibbaseid":"cape-bowman-kramer-computationoftheredoxandprotonationpropertiesofquinonestowardsthepredictionofredoxcyclingnaturalproducts-2006","downloads":0,"creationDate":"2016-02-18T13:03:35.436Z","title":"Computation of the Redox and Protonation Properties of Quinones: Towards the Prediction of Redox Cycling Natural Products.","author_short":["Cape, J. L","Bowman, M. K","Kramer, D. M"],"year":2006,"bibtype":"article","biburl":"https://dl.dropboxusercontent.com/u/26998770/main.bib","bibdata":{"bibtype":"article","type":"article","abstract":"Quinone metabolites perform a variety of key functions in plants, including pathogen protection, oxidative phosphorylation, and redox signaling. Many of these structurally diverse compounds have been shown to exhibit potent antimicrobial, anticancer, and anti-inflammatory properties, although the exact mechanisms of action are far from understood. Redox cycling has been proposed as a possible mechanism of action for many quinone species. Experimental determination of the essential thermodynamic data (i.e. electrochemical and pKa values) required to predict the propensity towards redox cycling is often difficult or impossible to obtain due to experimental limitations. We demonstrate a practical computational approach to obtain reasonable estimates of these parameters.","address":"Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6314, USA.","au":"Cape, JL and Bowman, MK and Kramer, DM","author":[{"propositions":[],"lastnames":["Cape"],"firstnames":["Jonathan","L"],"suffixes":[]},{"propositions":[],"lastnames":["Bowman"],"firstnames":["Michael","K"],"suffixes":[]},{"propositions":[],"lastnames":["Kramer"],"firstnames":["David","M"],"suffixes":[]}],"da":"20060825","date-added":"2007-12-11 17:01:03 -0500","date-modified":"2008-11-29 20:29:44 -0500","dcom":"20061026","dep":"20060726","doi":"10.1016/j.phytochem.2006.06.015","edat":"2006/07/29 09:00","gr":"GM61904/GM/NIGMS","issn":"0031-9422 (Print)","jid":"0151434","journal":"Phytochemistry","jt":"Phytochemistry","keywords":"redox cycling","language":"eng","local-url":"file://localhost/Users/rguha/Documents/articles/redox-cycling.pdf","lr":"20061115","mhda":"2006/10/27 09:00","number":"16","own":"NLM","pages":"1781--1788","phst":"2006/03/06 $[$received$]$; 2006/06/09 $[$revised$]$; 2006/06/13 $[$accepted$]$; 2006/07/26 $[$aheadofprint$]$","pii":"S0031-9422(06)00348-7","pl":"United States","pmid":"16872647","pst":"ppublish","pt":"Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.","pubm":"Print-Electronic","rn":"0 (Biological Products); 0 (Protons); 0 (Quinones)","sb":"IM","so":"Phytochemistry. 2006 Aug;67(16):1781-8. Epub 2006 Jul 26.","stat":"MEDLINE","title":"Computation of the Redox and Protonation Properties of Quinones: Towards the Prediction of Redox Cycling Natural Products.","url":"http://dx.doi.org/10.1016/j.phytochem.2006.06.015","volume":"67","year":"2006","bdsk-file-1":"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","bdsk-url-1":"http://dx.doi.org/10.1016/j.phytochem.2006.06.015","bdsk-url-2":"http://dx.doi.org/10.1016/j.phytochem.2006.06.015","bibtex":"@article{Cape:2006aa,\n\tAbstract = {Quinone metabolites perform a variety of key functions in plants, including pathogen protection, oxidative phosphorylation, and redox signaling. Many of these structurally diverse compounds have been shown to exhibit potent antimicrobial, anticancer, and anti-inflammatory properties, although the exact mechanisms of action are far from understood. Redox cycling has been proposed as a possible mechanism of action for many quinone species. Experimental determination of the essential thermodynamic data (i.e. electrochemical and pKa values) required to predict the propensity towards redox cycling is often difficult or impossible to obtain due to experimental limitations. We demonstrate a practical computational approach to obtain reasonable estimates of these parameters.},\n\tAddress = {Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6314, USA.},\n\tAu = {Cape, JL and Bowman, MK and Kramer, DM},\n\tAuthor = {Cape, Jonathan L and Bowman, Michael K and Kramer, David M},\n\tDa = {20060825},\n\tDate-Added = {2007-12-11 17:01:03 -0500},\n\tDate-Modified = {2008-11-29 20:29:44 -0500},\n\tDcom = {20061026},\n\tDep = {20060726},\n\tDoi = {10.1016/j.phytochem.2006.06.015},\n\tEdat = {2006/07/29 09:00},\n\tGr = {GM61904/GM/NIGMS},\n\tIssn = {0031-9422 (Print)},\n\tJid = {0151434},\n\tJournal = {Phytochemistry},\n\tJt = {Phytochemistry},\n\tKeywords = {redox cycling},\n\tLanguage = {eng},\n\tLocal-Url = {file://localhost/Users/rguha/Documents/articles/redox-cycling.pdf},\n\tLr = {20061115},\n\tMhda = {2006/10/27 09:00},\n\tNumber = {16},\n\tOwn = {NLM},\n\tPages = {1781--1788},\n\tPhst = {2006/03/06 {$[$}received{$]$}; 2006/06/09 {$[$}revised{$]$}; 2006/06/13 {$[$}accepted{$]$}; 2006/07/26 {$[$}aheadofprint{$]$}},\n\tPii = {S0031-9422(06)00348-7},\n\tPl = {United States},\n\tPmid = {16872647},\n\tPst = {ppublish},\n\tPt = {Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.},\n\tPubm = {Print-Electronic},\n\tRn = {0 (Biological Products); 0 (Protons); 0 (Quinones)},\n\tSb = {IM},\n\tSo = {Phytochemistry. 2006 Aug;67(16):1781-8. Epub 2006 Jul 26.},\n\tStat = {MEDLINE},\n\tTitle = {Computation of the Redox and Protonation Properties of Quinones: Towards the Prediction of Redox Cycling Natural Products.},\n\tUrl = {http://dx.doi.org/10.1016/j.phytochem.2006.06.015},\n\tVolume = {67},\n\tYear = {2006},\n\tBdsk-File-1 = {YnBsaXN0MDDUAQIDBAUIJidUJHRvcFgkb2JqZWN0c1gkdmVyc2lvblkkYXJjaGl2ZXLRBgdUcm9vdIABqAkKFRYXGyIjVSRudWxs0wsMDQ4RElpOUy5vYmplY3RzViRjbGFzc1dOUy5rZXlzog8QgASABoAHohMUgAKAA1lhbGlhc0RhdGFccmVsYXRpdmVQYXRo0hgMGRpXTlMuZGF0YU8RAX4AAAAAAX4AAgAAA212IAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAMU5bQNIKwAAABCNbRFyZWRveC1jeWNsaW5nLnBkZgAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAEI/RwoYAmwAAAAAAAAAAAAIAAwAACSAAAAAAAAAAAAAAAAAAAAAIYXJ0aWNsZXMAEAAIAADFObNTAAAAEQAIAADChjjbAAAAAQAQABCNbQAKTIAACkxpAAB8EwACADRtdiA6VXNlcnM6cmd1aGE6RG9jdW1lbnRzOmFydGljbGVzOnJlZG94LWN5Y2xpbmcucGRmAA4AJAARAHIAZQBkAG8AeAAtAGMAeQBjAGwAaQBuAGcALgBwAGQAZgAPAAgAAwBtAHYAIAASADBVc2Vycy9yZ3VoYS9Eb2N1bWVudHMvYXJ0aWNsZXMvcmVkb3gtY3ljbGluZy5wZGYAEwABLwAAFQACAAz//wAAgAXSHB0eH1gkY2xhc3Nlc1okY2xhc3NuYW1lox8gIV1OU011dGFibGVEYXRhVk5TRGF0YVhOU09iamVjdF8QKi4uLy4uL0RvY3VtZW50cy9hcnRpY2xlcy9yZWRveC1jeWNsaW5nLnBkZtIcHSQloiUhXE5TRGljdGlvbmFyeRIAAYagXxAPTlNLZXllZEFyY2hpdmVyAAgAEQAWAB8AKAAyADUAOgA8AEUASwBSAF0AZABsAG8AcQBzAHUAeAB6AHwAhgCTAJgAoAIiAiQCKQIyAj0CQQJPAlYCXwKMApEClAKhAqYAAAAAAAACAQAAAAAAAAAoAAAAAAAAAAAAAAAAAAACuA==},\n\tBdsk-Url-1 = {http://dx.doi.org/10.1016/j.phytochem.2006.06.015},\n\tBdsk-Url-2 = {http://dx.doi.org/10.1016/j.phytochem.2006.06.015}}\n\n","author_short":["Cape, J. L","Bowman, M. K","Kramer, D. M"],"key":"Cape:2006aa","id":"Cape:2006aa","bibbaseid":"cape-bowman-kramer-computationoftheredoxandprotonationpropertiesofquinonestowardsthepredictionofredoxcyclingnaturalproducts-2006","role":"author","urls":{"Paper":"http://dx.doi.org/10.1016/j.phytochem.2006.06.015"},"keyword":["redox cycling"],"downloads":0},"search_terms":["computation","redox","protonation","properties","quinones","towards","prediction","redox","cycling","natural","products","cape","bowman","kramer"],"keywords":["redox cycling"],"authorIDs":[],"dataSources":["c5japf9eAQRaeMS4h"]}