O-Aryl-Glycoside Ice Recrystallization Inhibitors as Novel Cryoprotectants: A Structure–Function Study. Capicciotti, C. J., Mancini, R. S., Turner, T. R., Koyama, T., Alteen, M. G., Doshi, M., Inada, T., Acker, J. P., & Ben, R. N. ACS Omega, 1(4):656–662, October, 2016. Publisher: American Chemical Society![O-Aryl-Glycoside Ice Recrystallization Inhibitors as Novel Cryoprotectants: A Structure–Function Study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Low-molecular-weight ice recrystallization inhibitors (IRIs) are ideal cryoprotectants that control the growth of ice and mitigate cell damage during freezing. Herein, we describe a detailed study correlating the ice recrystallization inhibition activity and the cryopreservation ability with the structure of O-aryl-glycosides. Many effective IRIs are efficient cryoadditives for the freezing of red blood cells (RBCs). One effective cryoadditive did not inhibit ice recrystallization but instead inhibited ice nucleation, demonstrating the significance of inhibiting both processes and illustrating the importance of this emerging class of cryoprotectants.
@article{capicciotti_o-aryl-glycoside_2016,
title = {O-{Aryl}-{Glycoside} {Ice} {Recrystallization} {Inhibitors} as {Novel} {Cryoprotectants}: {A} {Structure}–{Function} {Study}},
volume = {1},
shorttitle = {O-{Aryl}-{Glycoside} {Ice} {Recrystallization} {Inhibitors} as {Novel} {Cryoprotectants}},
url = {https://doi.org/10.1021/acsomega.6b00163},
doi = {10.1021/acsomega.6b00163},
abstract = {Low-molecular-weight ice recrystallization inhibitors (IRIs) are ideal cryoprotectants that control the growth of ice and mitigate cell damage during freezing. Herein, we describe a detailed study correlating the ice recrystallization inhibition activity and the cryopreservation ability with the structure of O-aryl-glycosides. Many effective IRIs are efficient cryoadditives for the freezing of red blood cells (RBCs). One effective cryoadditive did not inhibit ice recrystallization but instead inhibited ice nucleation, demonstrating the significance of inhibiting both processes and illustrating the importance of this emerging class of cryoprotectants.},
number = {4},
urldate = {2022-01-20},
journal = {ACS Omega},
author = {Capicciotti, Chantelle J. and Mancini, Ross S. and Turner, Tracey R. and Koyama, Toshie and Alteen, Matthew G. and Doshi, Malay and Inada, Takaaki and Acker, Jason P. and Ben, Robert N.},
month = oct,
year = {2016},
note = {Publisher: American Chemical Society},
pages = {656--662},
}
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