Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Carhart-Harris, R., L., Bolstridge, &., M., Day, C., M., J., Rucker, J., Watts, &., R., Erritzoe, &., D., E., Kaelen, &., M., Giribaldi, &., B., Bloomfield, &., M., Pilling, &., S., Rickard, J., A., Forbes, B., Feilding, &., A., Taylor, &., D., Curran, H., V., & Nutt, &., D., J. Barts Health Pharmaceuticals, Barts Health NHS Trust, the Royal London Hospital. ![Psilocybin with psychological support for treatment-resistant depression: six-month follow-up [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex Rationale Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on safety and efficacy outcomes for up to 6 months in an open-label trial of psilocybin for treatment-resistant depression. Methods Twenty patients (six females) with (mostly) severe , unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 and 25 mg, 7 days apart) in a supportive setting. Depressive symptoms were assessed from 1 week to 6 months post-treatment, with the self-rated QIDS-SR16 as the primary outcome measure. Results Treatment was generally well tolerated. Relative to base-line, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen's d = 2.2 at week 1 and 2.3 at week 5, both p < 0.001); nine and four patients met the criteria for response and remission at week 5. Results remained positive at 3 and 6 months (Cohen's d = 1.5 and 1.4, respectively, both p < 0.001). No patients sought conventional antidepressant treatment within 5 weeks of psilocybin. Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience. Conclusions Although limited conclusions can be drawn about treatment efficacy from open-label trials, tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment-resistant cohort. Psilocybin represents a promising paradigm for unresponsive depression that warrants further research in double-blind randomised control trials.
@article{
title = {Psilocybin with psychological support for treatment-resistant depression: six-month follow-up},
type = {article},
identifiers = {[object Object]},
keywords = {5-HT2AR,Depression,Hallucinogen,Mood,Psilocybin,Psychedelic,Psychotherapy,Serotonin,Treatment-resistant depression},
websites = {https://doi.org/10.1007/s00213-017-4771-x},
id = {22417819-6026-3adb-a449-193438d32d12},
created = {2019-07-05T23:01:37.593Z},
accessed = {2019-07-06},
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last_modified = {2019-07-05T23:01:37.593Z},
tags = {Disc:Psychopharmacology,OA},
read = {false},
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abstract = {Rationale Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on safety and efficacy outcomes for up to 6 months in an open-label trial of psilocybin for treatment-resistant depression. Methods Twenty patients (six females) with (mostly) severe , unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 and 25 mg, 7 days apart) in a supportive setting. Depressive symptoms were assessed from 1 week to 6 months post-treatment, with the self-rated QIDS-SR16 as the primary outcome measure. Results Treatment was generally well tolerated. Relative to base-line, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen's d = 2.2 at week 1 and 2.3 at week 5, both p < 0.001); nine and four patients met the criteria for response and remission at week 5. Results remained positive at 3 and 6 months (Cohen's d = 1.5 and 1.4, respectively, both p < 0.001). No patients sought conventional antidepressant treatment within 5 weeks of psilocybin. Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience. Conclusions Although limited conclusions can be drawn about treatment efficacy from open-label trials, tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment-resistant cohort. Psilocybin represents a promising paradigm for unresponsive depression that warrants further research in double-blind randomised control trials.},
bibtype = {article},
author = {Carhart-Harris, R L and Bolstridge, & M and Day, C M J and Rucker, J and Watts, & R and Erritzoe, & D E and Kaelen, & M and Giribaldi, & B and Bloomfield, & M and Pilling, & S and Rickard, J A and Forbes, B and Feilding, & A and Taylor, & D and Curran, H V and Nutt, & D J},
journal = {Barts Health Pharmaceuticals, Barts Health NHS Trust, the Royal London Hospital}
}
Downloads: 0
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Objectives Here, we report on safety and efficacy outcomes for up to 6 months in an open-label trial of psilocybin for treatment-resistant depression. Methods Twenty patients (six females) with (mostly) severe , unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 and 25 mg, 7 days apart) in a supportive setting. Depressive symptoms were assessed from 1 week to 6 months post-treatment, with the self-rated QIDS-SR16 as the primary outcome measure. Results Treatment was generally well tolerated. Relative to base-line, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen's d = 2.2 at week 1 and 2.3 at week 5, both p < 0.001); nine and four patients met the criteria for response and remission at week 5. Results remained positive at 3 and 6 months (Cohen's d = 1.5 and 1.4, respectively, both p < 0.001). No patients sought conventional antidepressant treatment within 5 weeks of psilocybin. Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience. Conclusions Although limited conclusions can be drawn about treatment efficacy from open-label trials, tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment-resistant cohort. 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Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience. Conclusions Although limited conclusions can be drawn about treatment efficacy from open-label trials, tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment-resistant cohort. 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