Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Carhart-Harris, R., L., Bolstridge, M., Day, C., M., Rucker, J., J., Watts, R., Erritzoe, D., Kaelen, M., Giribaldi, B., Bloomfield, M., Pilling, S., Rickard, J., A., Forbes, B., Feilding, A., Taylor, D., Curran, H., V., & Nutt, D., J. Psychopharmacology, 235(2):399-408, 2018. Website abstract bibtex RATIONALE Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy. OBJECTIVES Here, we report on safety and efficacy outcomes for up to 6 months in an open-label trial of psilocybin for treatment-resistant depression. METHODS Twenty patients (six females) with (mostly) severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 and 25 mg, 7 days apart) in a supportive setting. Depressive symptoms were assessed from 1 week to 6 months post-treatment, with the self-rated QIDS-SR16 as the primary outcome measure. RESULTS Treatment was generally well tolerated. Relative to baseline, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen's d = 2.2 at week 1 and 2.3 at week 5, both p < 0.001); nine and four patients met the criteria for response and remission at week 5. Results remained positive at 3 and 6 months (Cohen's d = 1.5 and 1.4, respectively, both p < 0.001). No patients sought conventional antidepressant treatment within 5 weeks of psilocybin. Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience. CONCLUSIONS Although limited conclusions can be drawn about treatment efficacy from open-label trials, tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment-resistant cohort. Psilocybin represents a promising paradigm for unresponsive depression that warrants further research in double-blind randomised control trials.
@article{
title = {Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.},
type = {article},
year = {2018},
identifiers = {[object Object]},
keywords = {5-HT2AR,Depression,Hallucinogen,Mood,Psilocybin,Psychedelic,Psychotherapy,Serotonin,Treatment-resistant depression},
pages = {399-408},
volume = {235},
websites = {https://doi.org/10.1007/s00213-017-4771-x,http://www.ncbi.nlm.nih.gov/pubmed/29119217%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5813086},
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created = {2019-07-05T23:01:37.593Z},
accessed = {2019-07-06},
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group_id = {d9389c6c-8ab5-3b8b-86ed-33db09ca0198},
last_modified = {2019-10-23T13:46:51.508Z},
tags = {Disc:Psychopharmacology,OA},
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starred = {false},
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abstract = {RATIONALE Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy. OBJECTIVES Here, we report on safety and efficacy outcomes for up to 6 months in an open-label trial of psilocybin for treatment-resistant depression. METHODS Twenty patients (six females) with (mostly) severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 and 25 mg, 7 days apart) in a supportive setting. Depressive symptoms were assessed from 1 week to 6 months post-treatment, with the self-rated QIDS-SR16 as the primary outcome measure. RESULTS Treatment was generally well tolerated. Relative to baseline, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen's d = 2.2 at week 1 and 2.3 at week 5, both p < 0.001); nine and four patients met the criteria for response and remission at week 5. Results remained positive at 3 and 6 months (Cohen's d = 1.5 and 1.4, respectively, both p < 0.001). No patients sought conventional antidepressant treatment within 5 weeks of psilocybin. Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience. CONCLUSIONS Although limited conclusions can be drawn about treatment efficacy from open-label trials, tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment-resistant cohort. Psilocybin represents a promising paradigm for unresponsive depression that warrants further research in double-blind randomised control trials.},
bibtype = {article},
author = {Carhart-Harris, Robin Lester and Bolstridge, Mark and Day, Camilla M.J. and Rucker, James J.H. and Watts, Rosalind and Erritzoe, David and Kaelen, Mendel and Giribaldi, B and Bloomfield, Michael and Pilling, Steve and Rickard, James A. and Forbes, Ben and Feilding, Amanda and Taylor, David and Curran, H. Valerie and Nutt, David J.},
journal = {Psychopharmacology},
number = {2}
}
Downloads: 0
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Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience. CONCLUSIONS Although limited conclusions can be drawn about treatment efficacy from open-label trials, tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment-resistant cohort. Psilocybin represents a promising paradigm for unresponsive depression that warrants further research in double-blind randomised control trials.","bibtype":"article","author":"Carhart-Harris, Robin Lester and Bolstridge, Mark and Day, Camilla M.J. and Rucker, James J.H. and Watts, Rosalind and Erritzoe, David and Kaelen, Mendel and Giribaldi, B and Bloomfield, Michael and Pilling, Steve and Rickard, James A. and Forbes, Ben and Feilding, Amanda and Taylor, David and Curran, H. Valerie and Nutt, David J.","journal":"Psychopharmacology","number":"2","bibtex":"@article{\n title = {Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.},\n type = {article},\n year = {2018},\n identifiers = {[object Object]},\n keywords = {5-HT2AR,Depression,Hallucinogen,Mood,Psilocybin,Psychedelic,Psychotherapy,Serotonin,Treatment-resistant depression},\n pages = {399-408},\n volume = {235},\n websites = {https://doi.org/10.1007/s00213-017-4771-x,http://www.ncbi.nlm.nih.gov/pubmed/29119217%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5813086},\n id = {22417819-6026-3adb-a449-193438d32d12},\n created = {2019-07-05T23:01:37.593Z},\n accessed = {2019-07-06},\n file_attached = {false},\n profile_id = {38c6dbcb-2394-3f18-9217-58d777c08c69},\n group_id = {d9389c6c-8ab5-3b8b-86ed-33db09ca0198},\n last_modified = {2019-10-23T13:46:51.508Z},\n tags = {Disc:Psychopharmacology,OA},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {false},\n hidden = {false},\n private_publication = {false},\n abstract = {RATIONALE Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy. 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Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience. CONCLUSIONS Although limited conclusions can be drawn about treatment efficacy from open-label trials, tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment-resistant cohort. Psilocybin represents a promising paradigm for unresponsive depression that warrants further research in double-blind randomised control trials.},\n bibtype = {article},\n author = {Carhart-Harris, Robin Lester and Bolstridge, Mark and Day, Camilla M.J. and Rucker, James J.H. and Watts, Rosalind and Erritzoe, David and Kaelen, Mendel and Giribaldi, B and Bloomfield, Michael and Pilling, Steve and Rickard, James A. and Forbes, Ben and Feilding, Amanda and Taylor, David and Curran, H. 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