Diabetes mellitus and antipsychotic treatment in the United Kingdom. Carlson, C., Hornbuckle, K., DeLisle, F., Kryzhanovskaya, L., Breier, A., & Cavazzoni, P. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 16(5):366--375, July, 2006.
doi  abstract   bibtex   
OBJECTIVE: Treatment-emergent diabetes has been reported during exposure to conventional and atypical antipsychotics. This retrospective cohort study explored the UK General Practice Research Database (GPRD) to determine hazard ratios of diabetes for patients prescribed antipsychotics. METHODS: A Cox proportional hazard regression model using age, gender, and obesity (BMI \textgreater 30 kg/m2) was used to determine the hazard ratio (HR) of diabetes development in conventional antipsychotic (N = 59,089), atypical antipsychotic (N = 9053), individual antipsychotic, and general patient population cohorts (N = 1,491,548). RESULTS: Compared with the general GPRD patient population, patients exposed to conventional or atypical antipsychotics had a higher risk of developing diabetes (atypical antipsychotic cohort: HR = 2.9, CI = 2.0-4.4; and conventional antipsychotic cohort: HR = 1.9, CI = 1.6-2.3). The risk of developing diabetes during thioridazine, risperidone, or olanzapine treatment was significantly higher compared with the general GPRD patient population. CONCLUSION: Consistent with other epidemiology studies, this study supports an increased risk of developing diabetes during treatment with antipsychotics.
@article{carlson_diabetes_2006,
	title = {Diabetes mellitus and antipsychotic treatment in the {United} {Kingdom}},
	volume = {16},
	issn = {0924-977X},
	doi = {10.1016/j.euroneuro.2005.11.002},
	abstract = {OBJECTIVE: Treatment-emergent diabetes has been reported during exposure to conventional and atypical antipsychotics. This retrospective cohort study explored the UK General Practice Research Database (GPRD) to determine hazard ratios of diabetes for patients prescribed antipsychotics.
METHODS: A Cox proportional hazard regression model using age, gender, and obesity (BMI {\textgreater} 30 kg/m2) was used to determine the hazard ratio (HR) of diabetes development in conventional antipsychotic (N = 59,089), atypical antipsychotic (N = 9053), individual antipsychotic, and general patient population cohorts (N = 1,491,548).
RESULTS: Compared with the general GPRD patient population, patients exposed to conventional or atypical antipsychotics had a higher risk of developing diabetes (atypical antipsychotic cohort: HR = 2.9, CI = 2.0-4.4; and conventional antipsychotic cohort: HR = 1.9, CI = 1.6-2.3). The risk of developing diabetes during thioridazine, risperidone, or olanzapine treatment was significantly higher compared with the general GPRD patient population.
CONCLUSION: Consistent with other epidemiology studies, this study supports an increased risk of developing diabetes during treatment with antipsychotics.},
	language = {eng},
	number = {5},
	journal = {European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology},
	author = {Carlson, Christopher and Hornbuckle, Kenneth and DeLisle, Frank and Kryzhanovskaya, Ludmila and Breier, Alan and Cavazzoni, Patrizia},
	month = jul,
	year = {2006},
	pmid = {16356695},
	keywords = {Adolescent, Adult, Aged, Antipsychotic Agents, Body Mass Index, Cohort Studies, Databases, Factual, Female, Great Britain, Humans, Male, Middle Aged, Proportional Hazards Models, Regression Analysis, Retrospective Studies, Risk, diabetes mellitus},
	pages = {366--375}
}
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