Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches. Carothers, A., D., Rudan, I., Kolcic, I., Polasek, O., Hayward, C., Wright, A., F., Campbell, H., Teague, P., Hastie, N., D., & Weber, J., L. Annals of human genetics, 70(Pt 5):666-76, 9, 2006. ![Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex We have used genealogies and genomic polymorphisms to estimate individual inbreeding coefficients (F) in 50 subjects with an expected range (based on recent genealogies) of F from 0.0 to 0.0625. The estimates were based on two approaches, using genotypes respectively from 410 microsatellite markers (410-STR panel) and from 10,000 SNPs (10K-SNP panel). The latter was performed in a sub-sample of 15 individuals. We concluded that for both marker panels measures of inbreeding based on the excess of homozygosity over Hardy-Weinberg expectation were not closely correlated with 4-5 generation genealogical F-values. For the 10K-SNP panel we found two alternative measures which correlated more closely with F, based respectively on standard errors and on paired homozygosity of nearby SNPs over distances of 2-4 cM. We propose an empirical method for estimating standard errors and hence individual F-values, based on the variation between individual autosomes. This method could provide useful estimates of average F-values for groups of individuals in population-based studies of the effects of inbreeding/homozygosity on quantitative traits.
@article{
title = {Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches.},
type = {article},
year = {2006},
identifiers = {[object Object]},
keywords = {Consanguinity,Croatia,Genealogy and Heraldry,Genotype,Heterozygote,Homozygote,Humans,Microsatellite Repeats,Microsatellite Repeats: genetics,Polymorphism, Genetic,Polymorphism, Single Nucleotide,Scotland},
pages = {666-76},
volume = {70},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/16907711},
month = {9},
id = {086e45e5-2adb-395d-afc6-d2a9d5924aba},
created = {2017-06-19T13:39:43.143Z},
accessed = {2013-05-22},
file_attached = {false},
profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
group_id = {b2078731-0913-33b9-8902-a53629a24e83},
last_modified = {2017-06-19T13:39:43.259Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
abstract = {We have used genealogies and genomic polymorphisms to estimate individual inbreeding coefficients (F) in 50 subjects with an expected range (based on recent genealogies) of F from 0.0 to 0.0625. The estimates were based on two approaches, using genotypes respectively from 410 microsatellite markers (410-STR panel) and from 10,000 SNPs (10K-SNP panel). The latter was performed in a sub-sample of 15 individuals. We concluded that for both marker panels measures of inbreeding based on the excess of homozygosity over Hardy-Weinberg expectation were not closely correlated with 4-5 generation genealogical F-values. For the 10K-SNP panel we found two alternative measures which correlated more closely with F, based respectively on standard errors and on paired homozygosity of nearby SNPs over distances of 2-4 cM. We propose an empirical method for estimating standard errors and hence individual F-values, based on the variation between individual autosomes. This method could provide useful estimates of average F-values for groups of individuals in population-based studies of the effects of inbreeding/homozygosity on quantitative traits.},
bibtype = {article},
author = {Carothers, A D and Rudan, I and Kolcic, I and Polasek, O and Hayward, C and Wright, A F and Campbell, H and Teague, P and Hastie, N D and Weber, J L},
journal = {Annals of human genetics},
number = {Pt 5}
}
Downloads: 0
{"_id":"j8Tajp9tZ8fczTpnD","bibbaseid":"carothers-rudan-kolcic-polasek-hayward-wright-campbell-teague-etal-estimatinghumaninbreedingcoefficientscomparisonofgenealogicalandmarkerheterozygosityapproaches-2006","downloads":0,"creationDate":"2017-06-19T14:46:33.282Z","title":"Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches.","author_short":["Carothers, A., D.","Rudan, I.","Kolcic, I.","Polasek, O.","Hayward, C.","Wright, A., F.","Campbell, H.","Teague, P.","Hastie, N., D.","Weber, J., L."],"year":2006,"bibtype":"article","biburl":null,"bibdata":{"title":"Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches.","type":"article","year":"2006","identifiers":"[object Object]","keywords":"Consanguinity,Croatia,Genealogy and Heraldry,Genotype,Heterozygote,Homozygote,Humans,Microsatellite Repeats,Microsatellite Repeats: genetics,Polymorphism, Genetic,Polymorphism, Single Nucleotide,Scotland","pages":"666-76","volume":"70","websites":"http://www.ncbi.nlm.nih.gov/pubmed/16907711","month":"9","id":"086e45e5-2adb-395d-afc6-d2a9d5924aba","created":"2017-06-19T13:39:43.143Z","accessed":"2013-05-22","file_attached":false,"profile_id":"de68dde1-2ff3-3a4e-a214-ef424d0c7646","group_id":"b2078731-0913-33b9-8902-a53629a24e83","last_modified":"2017-06-19T13:39:43.259Z","read":false,"starred":false,"authored":false,"confirmed":"true","hidden":false,"abstract":"We have used genealogies and genomic polymorphisms to estimate individual inbreeding coefficients (F) in 50 subjects with an expected range (based on recent genealogies) of F from 0.0 to 0.0625. The estimates were based on two approaches, using genotypes respectively from 410 microsatellite markers (410-STR panel) and from 10,000 SNPs (10K-SNP panel). The latter was performed in a sub-sample of 15 individuals. We concluded that for both marker panels measures of inbreeding based on the excess of homozygosity over Hardy-Weinberg expectation were not closely correlated with 4-5 generation genealogical F-values. For the 10K-SNP panel we found two alternative measures which correlated more closely with F, based respectively on standard errors and on paired homozygosity of nearby SNPs over distances of 2-4 cM. We propose an empirical method for estimating standard errors and hence individual F-values, based on the variation between individual autosomes. This method could provide useful estimates of average F-values for groups of individuals in population-based studies of the effects of inbreeding/homozygosity on quantitative traits.","bibtype":"article","author":"Carothers, A D and Rudan, I and Kolcic, I and Polasek, O and Hayward, C and Wright, A F and Campbell, H and Teague, P and Hastie, N D and Weber, J L","journal":"Annals of human genetics","number":"Pt 5","bibtex":"@article{\n title = {Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches.},\n type = {article},\n year = {2006},\n identifiers = {[object Object]},\n keywords = {Consanguinity,Croatia,Genealogy and Heraldry,Genotype,Heterozygote,Homozygote,Humans,Microsatellite Repeats,Microsatellite Repeats: genetics,Polymorphism, Genetic,Polymorphism, Single Nucleotide,Scotland},\n pages = {666-76},\n volume = {70},\n websites = {http://www.ncbi.nlm.nih.gov/pubmed/16907711},\n month = {9},\n id = {086e45e5-2adb-395d-afc6-d2a9d5924aba},\n created = {2017-06-19T13:39:43.143Z},\n accessed = {2013-05-22},\n file_attached = {false},\n profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},\n group_id = {b2078731-0913-33b9-8902-a53629a24e83},\n last_modified = {2017-06-19T13:39:43.259Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n abstract = {We have used genealogies and genomic polymorphisms to estimate individual inbreeding coefficients (F) in 50 subjects with an expected range (based on recent genealogies) of F from 0.0 to 0.0625. The estimates were based on two approaches, using genotypes respectively from 410 microsatellite markers (410-STR panel) and from 10,000 SNPs (10K-SNP panel). The latter was performed in a sub-sample of 15 individuals. We concluded that for both marker panels measures of inbreeding based on the excess of homozygosity over Hardy-Weinberg expectation were not closely correlated with 4-5 generation genealogical F-values. For the 10K-SNP panel we found two alternative measures which correlated more closely with F, based respectively on standard errors and on paired homozygosity of nearby SNPs over distances of 2-4 cM. We propose an empirical method for estimating standard errors and hence individual F-values, based on the variation between individual autosomes. This method could provide useful estimates of average F-values for groups of individuals in population-based studies of the effects of inbreeding/homozygosity on quantitative traits.},\n bibtype = {article},\n author = {Carothers, A D and Rudan, I and Kolcic, I and Polasek, O and Hayward, C and Wright, A F and Campbell, H and Teague, P and Hastie, N D and Weber, J L},\n journal = {Annals of human genetics},\n number = {Pt 5}\n}","author_short":["Carothers, A., D.","Rudan, I.","Kolcic, I.","Polasek, O.","Hayward, C.","Wright, A., F.","Campbell, H.","Teague, P.","Hastie, N., D.","Weber, J., L."],"urls":{"Website":"http://www.ncbi.nlm.nih.gov/pubmed/16907711"},"bibbaseid":"carothers-rudan-kolcic-polasek-hayward-wright-campbell-teague-etal-estimatinghumaninbreedingcoefficientscomparisonofgenealogicalandmarkerheterozygosityapproaches-2006","role":"author","keyword":["Consanguinity","Croatia","Genealogy and Heraldry","Genotype","Heterozygote","Homozygote","Humans","Microsatellite Repeats","Microsatellite Repeats: genetics","Polymorphism","Genetic","Polymorphism","Single Nucleotide","Scotland"],"downloads":0},"search_terms":["estimating","human","inbreeding","coefficients","comparison","genealogical","marker","heterozygosity","approaches","carothers","rudan","kolcic","polasek","hayward","wright","campbell","teague","hastie","weber"],"keywords":["consanguinity","croatia","genealogy and heraldry","genotype","heterozygote","homozygote","humans","microsatellite repeats","microsatellite repeats: genetics","polymorphism","genetic","polymorphism","single nucleotide","scotland"],"authorIDs":[]}