@article{carr_use_2025,
	title = {Use of {High}-{Dose} {Hydroxocobalamin} for {Septic} {Shock}},
	volume = {0},
	issn = {0012-3692},
	url = {https://journal.chestnet.org/article/S0012-3692(25)00129-1/abstract},
	doi = {10.1016/j.chest.2025.01.016},
	abstract = {Septic shock, a global health burden with a case fatality rate exceeding 40\%, is initiated
and maintained by circulating nitric oxide and hydrogen sulfide that are emergent
targets of therapeutic interest.1 High-dose (5-gm) hydroxocobalamin (vitamin B12)
(HD-HOC) scavenges circulating nitric oxide and hydrogen sulfide and may attenuate
the inflammatory response in early septic shock.2 Since 2014, several case reports
and case series have reported that HD-HOC is associated with reduced vasopressor requirements
in adults with refractory vasodilatory shock (including septic shock).},
	language = {English},
	number = {0},
	urldate = {2025-04-25},
	journal = {CHEST},
	author = {Carr, Jason R. and Locke, Brian and Patel, Jayshil J. and Peltan, Ithan D. and Brown, Samuel M. and Bosch, Nicholas A. and Law, Anica C.},
	month = jan,
	year = {2025},
	pmid = {39864505},
	note = {Publisher: Elsevier},
}

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