Thiazole orange-peptide conjugates: sensitivity of DNA binding to chemical structure. Carreon, J. R, Mahon, K. P, & Kelley, S. O Organic letters, 6(4):517–9, March, 2004. ![Thiazole orange-peptide conjugates: sensitivity of DNA binding to chemical structure. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex [structure: see text] Derivatives of the highly fluorescent and DNA-binding dye thiazole orange (TO) are described that feature appended peptides. Functionalization of TO can be achieved at either of the endocyclic nitrogens, and the photophysical properties and DNA-binding modes are sensitive to the position of the tethered peptide. A series of TO-peptide conjugates are described, demonstrating the utility of a solid-phase synthesis approach to their preparation and illustrating how the photophysical and DNA-binding properties of the compounds are influenced by chemical structure.
@article{Carreon2004,
title = {Thiazole orange-peptide conjugates: sensitivity of {DNA} binding to chemical structure.},
volume = {6},
issn = {1523-7060},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14961612},
doi = {10.1021/ol0362818},
abstract = {[structure: see text] Derivatives of the highly fluorescent and DNA-binding dye thiazole orange (TO) are described that feature appended peptides. Functionalization of TO can be achieved at either of the endocyclic nitrogens, and the photophysical properties and DNA-binding modes are sensitive to the position of the tethered peptide. A series of TO-peptide conjugates are described, demonstrating the utility of a solid-phase synthesis approach to their preparation and illustrating how the photophysical and DNA-binding properties of the compounds are influenced by chemical structure.},
number = {4},
journal = {Organic letters},
author = {Carreon, Jay R and Mahon, Kerry P and Kelley, Shana O},
month = mar,
year = {2004},
pmid = {14961612},
keywords = {\#nosource, Amino Acid Sequence, Benzothiazoles, DNA, DNA: chemistry, Fluorescent Dyes, Fluorescent Dyes: chemistry, Models, Molecular, Molecular Structure, Peptides, Peptides: chemistry, Quinolines, Structure-Activity Relationship, Thiazoles, Thiazoles: chemistry},
pages = {517--9},
}
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