@article{
 title = {Using Psilocybin to Investigate the Relationship between Attention, Working Memory, and the Serotonin 1A and 2A Receptors},
 type = {article},
 websites = {https://www.mitpressjournals.org/doi/pdf/10.1162/089892905774597191},
 id = {15f1289d-65ea-32a7-94b6-7b75d183cc7d},
 created = {2018-03-01T22:13:23.822Z},
 accessed = {2018-03-01},
 file_attached = {true},
 profile_id = {48f1fda5-0084-39cd-8cc7-68fcbd29ae85},
 group_id = {d9389c6c-8ab5-3b8b-86ed-33db09ca0198},
 last_modified = {2018-03-01T22:13:27.433Z},
 tags = {CA},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 abstract = {& Increasing evidence suggests a link between attention, working memory, serotonin (5-HT), and prefrontal cortex ac-tivity. In an attempt to tease out the relationship between these elements, this study tested the effects of the hallucinogenic mixed 5-HT 1A/2A receptor agonist psilocybin alone and after pretreatment with the 5-HT 2A antagonist ketanserin. Eight healthy human volunteers were tested on a multiple-object tracking task and spatial working memory task under the four conditions: placebo, psilocybin (215 Ag/kg), ketanserin (50 mg), and psilocybin and ketanserin. Psilocybin significantly reduced attentional tracking ability, but had no significant effect on spatial working memory, suggesting a functional dis-sociation between the two tasks. Pretreatment with ketanserin did not attenuate the effect of psilocybin on attentional per-formance, suggesting a primary involvement of the 5-HT 1A receptor in the observed deficit. Based on physiological and pharmacological data, we speculate that this impaired atten-tional performance may reflect a reduced ability to suppress or ignore distracting stimuli rather than reduced attentional capac-ity. The clinical relevance of these results is also discussed. &},
 bibtype = {article},
 author = {Carter, Olivia L and Burr, David C and Pettigrew, John D and Wallis, Guy M and Hasler, Felix and Vollenweider, Franz X}
}

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