Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma. Carter, D. L., MacFall, J. R., Clegg, S. T., Wan, X., Prescott, D. M., Charles, H. C., & Samulski, T. V. Int J Radiat Oncol Biol Phys, 40(4):815–822, 1998. abstract bibtex PURPOSE: To determine the feasibility of measuring temperature noninvasively with magnetic resonance imaging during hyperthermia treatment of human tumors. METHODS: The proton chemical shift detected using phase-difference magnetic resonance imaging (MRI) was used to measure temperature in phantoms and human tumors during treatment with hyperthermia. Four adult patients having high-grade primary sarcoma tumors of the lower leg received 5 hyperthermia treatments in the MR scanner using an MRI-compatible radiofrequency heating applicator. Prior to each treatment, an average of 3 fiberoptic temperature probes were invasively placed into the tumor (or phantom). Hyperthermia was applied concurrent with MR thermometry. Following completion of the treatment, regions of interest (ROI) were defined on MR phase images at each temperature probe location, in bone marrow, and in gel standards placed outside the heated region. The median phase difference (compared to pretreatment baseline images) was calculated for each ROI. This phase difference was corrected for phase drift observed in standards and bone marrow. The observed phase difference, with and without corrections, was correlated with the fiberoptic temperature measurements. RESULTS: The phase difference observed with MRI was found to correlate with temperature. Phantom measurements demonstrated a linear regression coefficient of 4.70 degrees phase difference per degree Celsius, with an R2 = 0.998. After human images with artifact were excluded, the linear regression demonstrated a correlation coefficient of 5.5 degrees phase difference per degree Celsius, with an R2 = 0.84. In both phantom and human treatments, temperature measured via corrected phase difference closely tracked measurements obtained with fiberoptic probes during the hyperthermia treatments. CONCLUSIONS: Proton chemical shift imaging with current MRI and hyperthermia technology can be used to monitor and control temperature during treatment of large tumors in the distal lower extremity.
@Article{RSM:Car98,
author = "D. L. Carter and J. R. MacFall and S. T. Clegg and X.
Wan and D. M. Prescott and H. C. Charles and T. V.
Samulski",
title = "Magnetic resonance thermometry during hyperthermia for
human high-grade sarcoma",
journal = "Int J Radiat Oncol Biol Phys",
volume = "40",
number = "4",
pages = "815--822",
abstract = "PURPOSE: To determine the feasibility of measuring
temperature noninvasively with magnetic resonance
imaging during hyperthermia treatment of human tumors.
METHODS: The proton chemical shift detected using
phase-difference magnetic resonance imaging (MRI) was
used to measure temperature in phantoms and human
tumors during treatment with hyperthermia. Four adult
patients having high-grade primary sarcoma tumors of
the lower leg received 5 hyperthermia treatments in the
MR scanner using an MRI-compatible radiofrequency
heating applicator. Prior to each treatment, an average
of 3 fiberoptic temperature probes were invasively
placed into the tumor (or phantom). Hyperthermia was
applied concurrent with MR thermometry. Following
completion of the treatment, regions of interest (ROI)
were defined on MR phase images at each temperature
probe location, in bone marrow, and in gel standards
placed outside the heated region. The median phase
difference (compared to pretreatment baseline images)
was calculated for each ROI. This phase difference was
corrected for phase drift observed in standards and
bone marrow. The observed phase difference, with and
without corrections, was correlated with the fiberoptic
temperature measurements. RESULTS: The phase difference
observed with MRI was found to correlate with
temperature. Phantom measurements demonstrated a linear
regression coefficient of 4.70 degrees phase difference
per degree Celsius, with an R2 = 0.998. After human
images with artifact were excluded, the linear
regression demonstrated a correlation coefficient of
5.5 degrees phase difference per degree Celsius, with
an R2 = 0.84. In both phantom and human treatments,
temperature measured via corrected phase difference
closely tracked measurements obtained with fiberoptic
probes during the hyperthermia treatments. CONCLUSIONS:
Proton chemical shift imaging with current MRI and
hyperthermia technology can be used to monitor and
control temperature during treatment of large tumors in
the distal lower extremity.",
keywords = "Adult Feasibility Studies Heat Humans *Hyperthermia,
Induced *Magnetic Resonance Imaging Models, Anatomic
Sarcoma/*therapy",
year = "1998",
}
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{"_id":"JFAmBcjgC8uwEWJHb","bibbaseid":"carter-macfall-clegg-wan-prescott-charles-samulski-magneticresonancethermometryduringhyperthermiaforhumanhighgradesarcoma-1998","downloads":0,"creationDate":"2016-07-01T21:38:31.192Z","title":"Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma","author_short":["Carter, D. L.","MacFall, J. R.","Clegg, S. T.","Wan, X.","Prescott, D. M.","Charles, H. C.","Samulski, T. V."],"year":1998,"bibtype":"article","biburl":"http://www.sci.utah.edu/~macleod/Bibtex/biglit.bib","bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["D.","L."],"propositions":[],"lastnames":["Carter"],"suffixes":[]},{"firstnames":["J.","R."],"propositions":[],"lastnames":["MacFall"],"suffixes":[]},{"firstnames":["S.","T."],"propositions":[],"lastnames":["Clegg"],"suffixes":[]},{"firstnames":["X."],"propositions":[],"lastnames":["Wan"],"suffixes":[]},{"firstnames":["D.","M."],"propositions":[],"lastnames":["Prescott"],"suffixes":[]},{"firstnames":["H.","C."],"propositions":[],"lastnames":["Charles"],"suffixes":[]},{"firstnames":["T.","V."],"propositions":[],"lastnames":["Samulski"],"suffixes":[]}],"title":"Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma","journal":"Int J Radiat Oncol Biol Phys","volume":"40","number":"4","pages":"815–822","abstract":"PURPOSE: To determine the feasibility of measuring temperature noninvasively with magnetic resonance imaging during hyperthermia treatment of human tumors. METHODS: The proton chemical shift detected using phase-difference magnetic resonance imaging (MRI) was used to measure temperature in phantoms and human tumors during treatment with hyperthermia. Four adult patients having high-grade primary sarcoma tumors of the lower leg received 5 hyperthermia treatments in the MR scanner using an MRI-compatible radiofrequency heating applicator. Prior to each treatment, an average of 3 fiberoptic temperature probes were invasively placed into the tumor (or phantom). Hyperthermia was applied concurrent with MR thermometry. Following completion of the treatment, regions of interest (ROI) were defined on MR phase images at each temperature probe location, in bone marrow, and in gel standards placed outside the heated region. The median phase difference (compared to pretreatment baseline images) was calculated for each ROI. This phase difference was corrected for phase drift observed in standards and bone marrow. The observed phase difference, with and without corrections, was correlated with the fiberoptic temperature measurements. RESULTS: The phase difference observed with MRI was found to correlate with temperature. Phantom measurements demonstrated a linear regression coefficient of 4.70 degrees phase difference per degree Celsius, with an R2 = 0.998. After human images with artifact were excluded, the linear regression demonstrated a correlation coefficient of 5.5 degrees phase difference per degree Celsius, with an R2 = 0.84. In both phantom and human treatments, temperature measured via corrected phase difference closely tracked measurements obtained with fiberoptic probes during the hyperthermia treatments. CONCLUSIONS: Proton chemical shift imaging with current MRI and hyperthermia technology can be used to monitor and control temperature during treatment of large tumors in the distal lower extremity.","keywords":"Adult Feasibility Studies Heat Humans *Hyperthermia, Induced *Magnetic Resonance Imaging Models, Anatomic Sarcoma/*therapy","year":"1998","bibtex":"@Article{RSM:Car98,\n author = \"D. L. Carter and J. R. MacFall and S. T. Clegg and X.\n Wan and D. M. Prescott and H. C. Charles and T. V.\n Samulski\",\n title = \"Magnetic resonance thermometry during hyperthermia for\n human high-grade sarcoma\",\n journal = \"Int J Radiat Oncol Biol Phys\",\n volume = \"40\",\n number = \"4\",\n pages = \"815--822\",\n abstract = \"PURPOSE: To determine the feasibility of measuring\n temperature noninvasively with magnetic resonance\n imaging during hyperthermia treatment of human tumors.\n METHODS: The proton chemical shift detected using\n phase-difference magnetic resonance imaging (MRI) was\n used to measure temperature in phantoms and human\n tumors during treatment with hyperthermia. Four adult\n patients having high-grade primary sarcoma tumors of\n the lower leg received 5 hyperthermia treatments in the\n MR scanner using an MRI-compatible radiofrequency\n heating applicator. Prior to each treatment, an average\n of 3 fiberoptic temperature probes were invasively\n placed into the tumor (or phantom). Hyperthermia was\n applied concurrent with MR thermometry. Following\n completion of the treatment, regions of interest (ROI)\n were defined on MR phase images at each temperature\n probe location, in bone marrow, and in gel standards\n placed outside the heated region. The median phase\n difference (compared to pretreatment baseline images)\n was calculated for each ROI. This phase difference was\n corrected for phase drift observed in standards and\n bone marrow. The observed phase difference, with and\n without corrections, was correlated with the fiberoptic\n temperature measurements. RESULTS: The phase difference\n observed with MRI was found to correlate with\n temperature. Phantom measurements demonstrated a linear\n regression coefficient of 4.70 degrees phase difference\n per degree Celsius, with an R2 = 0.998. After human\n images with artifact were excluded, the linear\n regression demonstrated a correlation coefficient of\n 5.5 degrees phase difference per degree Celsius, with\n an R2 = 0.84. In both phantom and human treatments,\n temperature measured via corrected phase difference\n closely tracked measurements obtained with fiberoptic\n probes during the hyperthermia treatments. CONCLUSIONS:\n Proton chemical shift imaging with current MRI and\n hyperthermia technology can be used to monitor and\n control temperature during treatment of large tumors in\n the distal lower extremity.\",\n keywords = \"Adult Feasibility Studies Heat Humans *Hyperthermia,\n Induced *Magnetic Resonance Imaging Models, Anatomic\n Sarcoma/*therapy\",\n year = \"1998\",\n}\n\n","author_short":["Carter, D. L.","MacFall, J. R.","Clegg, S. T.","Wan, X.","Prescott, D. M.","Charles, H. C.","Samulski, T. V."],"key":"RSM:Car98","id":"RSM:Car98","bibbaseid":"carter-macfall-clegg-wan-prescott-charles-samulski-magneticresonancethermometryduringhyperthermiaforhumanhighgradesarcoma-1998","role":"author","urls":{},"keyword":["Adult Feasibility Studies Heat Humans *Hyperthermia","Induced *Magnetic Resonance Imaging Models","Anatomic Sarcoma/*therapy"],"metadata":{"authorlinks":{}},"downloads":0,"html":""},"search_terms":["magnetic","resonance","thermometry","during","hyperthermia","human","high","grade","sarcoma","carter","macfall","clegg","wan","prescott","charles","samulski"],"keywords":["adult feasibility studies heat humans *hyperthermia","induced *magnetic resonance imaging models","anatomic sarcoma/*therapy"],"authorIDs":[],"dataSources":["5HG3Kp8zRwDd7FotB"]}