@article{cashin_commentaryan_2021,
	title = {{CommentaryAn} introduction to mediation analyses of randomised controlled trials},
	volume = {0},
	issn = {0895-4356, 1878-5921},
	url = {http://www.jclinepi.com/article/S0895-4356(21)00051-2/abstract},
	doi = {10.1016/j.jclinepi.2021.02.014},
	abstract = {{\textless}h2{\textgreater}Abstract{\textless}/h2{\textgreater}{\textless}p{\textgreater}Mediation analyses of randomised controlled trials can be used to investigate the mechanisms by which health interventions cause outcomes. In this article we provide a brief introduction to mediation analysis in the context of randomised controlled trials. We introduce common target effects, causal assumptions, estimation approaches, and illustrate these concepts using a published mediation analysis of the Systolic Blood Pressure Intervention Trial (SPRINT). Well-conducted mediation analyses of randomised trials can provide meaningful insights to guide clinical and policy decisions.{\textless}/p{\textgreater}},
	language = {English},
	number = {0},
	urldate = {2021-02-16},
	journal = {Journal of Clinical Epidemiology},
	author = {Cashin, Aidan G. and Lee, Hopin},
	month = feb,
	year = {2021},
	note = {Publisher: Elsevier},
	keywords = {adherence, compliance, mediation-effect, rct, teaching-mds},
}

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