{"_id":"mCucDEi444QPixErr","bibbaseid":"cashin-lee-commentaryanintroductiontomediationanalysesofrandomisedcontrolledtrials-2021","authorIDs":[],"author_short":["Cashin, A. G.","Lee, H."],"bibdata":{"bibtype":"article","type":"article","title":"CommentaryAn introduction to mediation analyses of randomised controlled trials","volume":"0","issn":"0895-4356, 1878-5921","url":"http://www.jclinepi.com/article/S0895-4356(21)00051-2/abstract","doi":"10.1016/j.jclinepi.2021.02.014","abstract":"\\textlessh2\\textgreaterAbstract\\textless/h2\\textgreater\\textlessp\\textgreaterMediation analyses of randomised controlled trials can be used to investigate the mechanisms by which health interventions cause outcomes. In this article we provide a brief introduction to mediation analysis in the context of randomised controlled trials. We introduce common target effects, causal assumptions, estimation approaches, and illustrate these concepts using a published mediation analysis of the Systolic Blood Pressure Intervention Trial (SPRINT). Well-conducted mediation analyses of randomised trials can provide meaningful insights to guide clinical and policy decisions.\\textless/p\\textgreater","language":"English","number":"0","urldate":"2021-02-16","journal":"Journal of Clinical Epidemiology","author":[{"propositions":[],"lastnames":["Cashin"],"firstnames":["Aidan","G."],"suffixes":[]},{"propositions":[],"lastnames":["Lee"],"firstnames":["Hopin"],"suffixes":[]}],"month":"February","year":"2021","note":"Publisher: Elsevier","keywords":"adherence, compliance, mediation-effect, rct, teaching-mds","bibtex":"@article{cashin_commentaryan_2021,\n\ttitle = {{CommentaryAn} introduction to mediation analyses of randomised controlled trials},\n\tvolume = {0},\n\tissn = {0895-4356, 1878-5921},\n\turl = {http://www.jclinepi.com/article/S0895-4356(21)00051-2/abstract},\n\tdoi = {10.1016/j.jclinepi.2021.02.014},\n\tabstract = {{\\textless}h2{\\textgreater}Abstract{\\textless}/h2{\\textgreater}{\\textless}p{\\textgreater}Mediation analyses of randomised controlled trials can be used to investigate the mechanisms by which health interventions cause outcomes. In this article we provide a brief introduction to mediation analysis in the context of randomised controlled trials. We introduce common target effects, causal assumptions, estimation approaches, and illustrate these concepts using a published mediation analysis of the Systolic Blood Pressure Intervention Trial (SPRINT). Well-conducted mediation analyses of randomised trials can provide meaningful insights to guide clinical and policy decisions.{\\textless}/p{\\textgreater}},\n\tlanguage = {English},\n\tnumber = {0},\n\turldate = {2021-02-16},\n\tjournal = {Journal of Clinical Epidemiology},\n\tauthor = {Cashin, Aidan G. and Lee, Hopin},\n\tmonth = feb,\n\tyear = {2021},\n\tnote = {Publisher: Elsevier},\n\tkeywords = {adherence, compliance, mediation-effect, rct, teaching-mds},\n}\n\n","author_short":["Cashin, A. G.","Lee, H."],"key":"cashin_commentaryan_2021","id":"cashin_commentaryan_2021","bibbaseid":"cashin-lee-commentaryanintroductiontomediationanalysesofrandomisedcontrolledtrials-2021","role":"author","urls":{"Paper":"http://www.jclinepi.com/article/S0895-4356(21)00051-2/abstract"},"keyword":["adherence","compliance","mediation-effect","rct","teaching-mds"],"downloads":0},"bibtype":"article","biburl":"https://api.zotero.org/groups/2199991/items?key=lvYOaZITy5xmJTj2Chg8pvSV&format=bibtex&limit=100","creationDate":"2021-03-21T22:45:08.713Z","downloads":0,"keywords":["adherence","compliance","mediation-effect","rct","teaching-mds"],"search_terms":["commentaryan","introduction","mediation","analyses","randomised","controlled","trials","cashin","lee"],"title":"CommentaryAn introduction to mediation analyses of randomised controlled trials","year":2021,"dataSources":["fGxngGYXSjSNcMccW"]}