Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Castellino, F., Huang, A., Y., Altan-Bonnet, G., Stoll, S., Scheinecker, C., & Germain, R., N. Nature, 440(7086):890-5, 5, 2006.
Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. [pdf]Paper  Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. [link]Website  abstract   bibtex   
CD8+ T cells have a crucial role in resistance to pathogens and can kill malignant cells; however, some critical functions of these lymphocytes depend on helper activity provided by a distinct population of CD4+ T cells. Cooperation between these lymphocyte subsets involves recognition of antigens co-presented by the same dendritic cell, but the frequencies of such antigen-bearing cells early in an infection and of the relevant naive T cells are both low. This suggests that an active mechanism facilitates the necessary cell-cell associations. Here we demonstrate that after immunization but before antigen recognition, naive CD8+ T cells in immunogen-draining lymph nodes upregulate the chemokine receptor CCR5, permitting these cells to be attracted to sites of antigen-specific dendritic cell-CD4+ T cell interaction where the cognate chemokines CCL3 and CCL4 (also known as MIP-1alpha and MIP-1beta) are produced. Interference with this actively guided recruitment markedly reduces the ability of CD4+ T cells to promote memory CD8+ T-cell generation, indicating that an orchestrated series of differentiation events drives nonrandom cell-cell interactions within lymph nodes, optimizing CD8+ T-cell immune responses involving the few antigen-specific precursors present in the naive repertoire.
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 title = {Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction.},
 type = {article},
 year = {2006},
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 keywords = {Animals,CD4-Positive T-Lymphocytes,CD4-Positive T-Lymphocytes: cytology,CD4-Positive T-Lymphocytes: immunology,CD8-Positive T-Lymphocytes,CD8-Positive T-Lymphocytes: cytology,CD8-Positive T-Lymphocytes: immunology,Cell Adhesion,Cell Communication,Cell Movement,Chemokine CCL3,Chemokine CCL4,Chemokines,Chemokines, CC,Chemokines, CC: immunology,Chemokines, CC: metabolism,Chemokines: antagonists & inhibitors,Chemokines: immunology,Chemokines: metabolism,Dendritic Cells,Dendritic Cells: cytology,Dendritic Cells: immunology,Immunologic Memory,Immunologic Memory: immunology,Lymph Nodes,Lymph Nodes: cytology,Lymph Nodes: immunology,Lymphocyte Activation,Macrophage Inflammatory Proteins,Macrophage Inflammatory Proteins: immunology,Macrophage Inflammatory Proteins: metabolism,Mice,Receptors, CCR5,Receptors, CCR5: immunology,Receptors, CCR5: metabolism},
 pages = {890-5},
 volume = {440},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/16612374},
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 abstract = {CD8+ T cells have a crucial role in resistance to pathogens and can kill malignant cells; however, some critical functions of these lymphocytes depend on helper activity provided by a distinct population of CD4+ T cells. Cooperation between these lymphocyte subsets involves recognition of antigens co-presented by the same dendritic cell, but the frequencies of such antigen-bearing cells early in an infection and of the relevant naive T cells are both low. This suggests that an active mechanism facilitates the necessary cell-cell associations. Here we demonstrate that after immunization but before antigen recognition, naive CD8+ T cells in immunogen-draining lymph nodes upregulate the chemokine receptor CCR5, permitting these cells to be attracted to sites of antigen-specific dendritic cell-CD4+ T cell interaction where the cognate chemokines CCL3 and CCL4 (also known as MIP-1alpha and MIP-1beta) are produced. Interference with this actively guided recruitment markedly reduces the ability of CD4+ T cells to promote memory CD8+ T-cell generation, indicating that an orchestrated series of differentiation events drives nonrandom cell-cell interactions within lymph nodes, optimizing CD8+ T-cell immune responses involving the few antigen-specific precursors present in the naive repertoire.},
 bibtype = {article},
 author = {Castellino, Flora and Huang, Alex Y and Altan-Bonnet, Grégoire and Stoll, Sabine and Scheinecker, Clemens and Germain, Ronald N},
 journal = {Nature},
 number = {7086}
}
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