@article{ Cauwelier2007,
  author    = {Barbara Cauwelier and Hélène Cavé and C Gervais and Michel Lessard and C Barin and C Perot and J Van den Akker and F Mugneret and C Charrin and M P Pagès and M J Grégoire and P Jonveaux and Marina Lafage-Pochitaloff and M J Mozzicconacci and C Terré and I Luquet and P Cornillet-Lefebvre and B Laurence and G Plessis and C Lefebvre and D Leroux and H Antoine-Poirel and Carlos Graux and Laurent Mauvieux and P Heimann and C Chalas and E Clappier and Bruno Verhasselt and Yves Benoit and B D Moerloose and Bruce Poppe and Nadine Van Roy and K D Keersmaecker and Jan Cools and F Sigaux and J Soulier and Anne Hagemeijer and Anne De Paepe and Nicole Dastugue and R Berger and Frank Speleman},
  title     = {Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRbeta-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique.},
  journal   = {Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K}, 
  abstract   = {Recently, we and others described a new chromosomal rearrangement, that is, inv(7)(p15q34) and t(7;7)(p15;q34) involving the T-cell receptor beta (TCRbeta) (7q34) and the HOXA gene locus (7p15) in 5\% of T-cell acute lymphoblastic leukemia (T-ALL) patients leading to transcriptional activation of especially HOXA10. To further address the clinical, immunophenotypical and molecular genetic findings of this chromosomal aberration, we studied 330 additional T-ALLs. This revealed TCRbeta-HOXA rearrangements in five additional patients, which brings the total to 14 cases in 424 patients (3.3\%). Real-time quantitative PCR analysis for HOXA10 gene expression was performed in 170 T-ALL patients and detected HOXA10 overexpression in 25.2\% of cases including all the cases with a TCRbeta-HOXA rearrangement (8.2\%). In contrast, expression of the short HOXA10 transcript, HOXA10b, was almost exclusively found in the TCRbeta-HOXA rearranged cases, suggesting a specific role for the HOXA10b short transcript in TCRbeta-HOXA-mediated oncogenesis. Other molecular and/or cytogenetic aberrations frequently found in subtypes of T-ALL (SIL-TAL1, CALM-AF10, HOX11, HOX11L2) were not detected in the TCRbeta-HOXA rearranged cases except for deletion 9p21 and NOTCH1 activating mutations, which were present in 64 and 67\%, respectively. In conclusion, this study defines TCRbeta-HOXA rearranged T-ALLs as a distinct cytogenetic subgroup by clinical, immunophenotypical and molecular genetic characteristics.},
  issn   = {0887-6924},
  month   = {January},
  pages   = {121--8},
  volume   = {21},
  number   = {1},
  url   = {http://www.ncbi.nlm.nih.gov/pubmed/17039236} ,
  year   = {2007}
}

{"_id":"iBSujbh6m3ygnhDk9","bibbaseid":"cauwelier-cav-gervais-lessard-barin-perot-denakker-mugneret-etal-clinicalcytogeneticandmolecularcharacteristicsof14tallpatientscarryingthetcrbetahoxarearrangementastudyofthegroupefrancophonedecytogntiquehmatologique-2007","downloads":0,"creationDate":"2015-12-06T21:00:24.753Z","title":"Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRbeta-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique.","author_short":["Cauwelier, B.","Cavé, H.","Gervais, C","Lessard, M.","Barin, C","Perot, C","den Akker, J V.","Mugneret, F","Charrin, C","Pagès, M P","Grégoire, M J","Jonveaux, P","Lafage-Pochitaloff, M.","Mozzicconacci, M J","Terré, C","Luquet, I","Cornillet-Lefebvre, P","Laurence, B","Plessis, G","Lefebvre, C","Leroux, D","Antoine-Poirel, H","Graux, C.","Mauvieux, L.","Heimann, P","Chalas, C","Clappier, E","Verhasselt, B.","Benoit, Y.","Moerloose, B D","Poppe, B.","Roy, N. V.","Keersmaecker, K D","Cools, J.","Sigaux, F","Soulier, J","Hagemeijer, A.","Paepe, A. D.","Dastugue, N.","Berger, R","Speleman, F."],"year":2007,"bibtype":"article","biburl":"http://data.bibbase.org/author/h-antoine-poirel/?format=bibtex","bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["Barbara"],"propositions":[],"lastnames":["Cauwelier"],"suffixes":[]},{"firstnames":["Hélène"],"propositions":[],"lastnames":["Cavé"],"suffixes":[]},{"firstnames":["C"],"propositions":[],"lastnames":["Gervais"],"suffixes":[]},{"firstnames":["Michel"],"propositions":[],"lastnames":["Lessard"],"suffixes":[]},{"firstnames":["C"],"propositions":[],"lastnames":["Barin"],"suffixes":[]},{"firstnames":["C"],"propositions":[],"lastnames":["Perot"],"suffixes":[]},{"firstnames":["J","Van"],"propositions":["den"],"lastnames":["Akker"],"suffixes":[]},{"firstnames":["F"],"propositions":[],"lastnames":["Mugneret"],"suffixes":[]},{"firstnames":["C"],"propositions":[],"lastnames":["Charrin"],"suffixes":[]},{"firstnames":["M","P"],"propositions":[],"lastnames":["Pagès"],"suffixes":[]},{"firstnames":["M","J"],"propositions":[],"lastnames":["Grégoire"],"suffixes":[]},{"firstnames":["P"],"propositions":[],"lastnames":["Jonveaux"],"suffixes":[]},{"firstnames":["Marina"],"propositions":[],"lastnames":["Lafage-Pochitaloff"],"suffixes":[]},{"firstnames":["M","J"],"propositions":[],"lastnames":["Mozzicconacci"],"suffixes":[]},{"firstnames":["C"],"propositions":[],"lastnames":["Terré"],"suffixes":[]},{"firstnames":["I"],"propositions":[],"lastnames":["Luquet"],"suffixes":[]},{"firstnames":["P"],"propositions":[],"lastnames":["Cornillet-Lefebvre"],"suffixes":[]},{"firstnames":["B"],"propositions":[],"lastnames":["Laurence"],"suffixes":[]},{"firstnames":["G"],"propositions":[],"lastnames":["Plessis"],"suffixes":[]},{"firstnames":["C"],"propositions":[],"lastnames":["Lefebvre"],"suffixes":[]},{"firstnames":["D"],"propositions":[],"lastnames":["Leroux"],"suffixes":[]},{"firstnames":["H"],"propositions":[],"lastnames":["Antoine-Poirel"],"suffixes":[]},{"firstnames":["Carlos"],"propositions":[],"lastnames":["Graux"],"suffixes":[]},{"firstnames":["Laurent"],"propositions":[],"lastnames":["Mauvieux"],"suffixes":[]},{"firstnames":["P"],"propositions":[],"lastnames":["Heimann"],"suffixes":[]},{"firstnames":["C"],"propositions":[],"lastnames":["Chalas"],"suffixes":[]},{"firstnames":["E"],"propositions":[],"lastnames":["Clappier"],"suffixes":[]},{"firstnames":["Bruno"],"propositions":[],"lastnames":["Verhasselt"],"suffixes":[]},{"firstnames":["Yves"],"propositions":[],"lastnames":["Benoit"],"suffixes":[]},{"firstnames":["B","D"],"propositions":[],"lastnames":["Moerloose"],"suffixes":[]},{"firstnames":["Bruce"],"propositions":[],"lastnames":["Poppe"],"suffixes":[]},{"firstnames":["Nadine","Van"],"propositions":[],"lastnames":["Roy"],"suffixes":[]},{"firstnames":["K","D"],"propositions":[],"lastnames":["Keersmaecker"],"suffixes":[]},{"firstnames":["Jan"],"propositions":[],"lastnames":["Cools"],"suffixes":[]},{"firstnames":["F"],"propositions":[],"lastnames":["Sigaux"],"suffixes":[]},{"firstnames":["J"],"propositions":[],"lastnames":["Soulier"],"suffixes":[]},{"firstnames":["Anne"],"propositions":[],"lastnames":["Hagemeijer"],"suffixes":[]},{"firstnames":["Anne","De"],"propositions":[],"lastnames":["Paepe"],"suffixes":[]},{"firstnames":["Nicole"],"propositions":[],"lastnames":["Dastugue"],"suffixes":[]},{"firstnames":["R"],"propositions":[],"lastnames":["Berger"],"suffixes":[]},{"firstnames":["Frank"],"propositions":[],"lastnames":["Speleman"],"suffixes":[]}],"title":"Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRbeta-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique.","journal":"Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K","abstract":"Recently, we and others described a new chromosomal rearrangement, that is, inv(7)(p15q34) and t(7;7)(p15;q34) involving the T-cell receptor beta (TCRbeta) (7q34) and the HOXA gene locus (7p15) in 5% of T-cell acute lymphoblastic leukemia (T-ALL) patients leading to transcriptional activation of especially HOXA10. To further address the clinical, immunophenotypical and molecular genetic findings of this chromosomal aberration, we studied 330 additional T-ALLs. This revealed TCRbeta-HOXA rearrangements in five additional patients, which brings the total to 14 cases in 424 patients (3.3%). Real-time quantitative PCR analysis for HOXA10 gene expression was performed in 170 T-ALL patients and detected HOXA10 overexpression in 25.2% of cases including all the cases with a TCRbeta-HOXA rearrangement (8.2%). In contrast, expression of the short HOXA10 transcript, HOXA10b, was almost exclusively found in the TCRbeta-HOXA rearranged cases, suggesting a specific role for the HOXA10b short transcript in TCRbeta-HOXA-mediated oncogenesis. Other molecular and/or cytogenetic aberrations frequently found in subtypes of T-ALL (SIL-TAL1, CALM-AF10, HOX11, HOX11L2) were not detected in the TCRbeta-HOXA rearranged cases except for deletion 9p21 and NOTCH1 activating mutations, which were present in 64 and 67%, respectively. In conclusion, this study defines TCRbeta-HOXA rearranged T-ALLs as a distinct cytogenetic subgroup by clinical, immunophenotypical and molecular genetic characteristics.","issn":"0887-6924","month":"January","pages":"121--8","volume":"21","number":"1","url":"http://www.ncbi.nlm.nih.gov/pubmed/17039236","year":"2007","bibtex":"@article{ Cauwelier2007,\n author = {Barbara Cauwelier and Hélène Cavé and C Gervais and Michel Lessard and C Barin and C Perot and J Van den Akker and F Mugneret and C Charrin and M P Pagès and M J Grégoire and P Jonveaux and Marina Lafage-Pochitaloff and M J Mozzicconacci and C Terré and I Luquet and P Cornillet-Lefebvre and B Laurence and G Plessis and C Lefebvre and D Leroux and H Antoine-Poirel and Carlos Graux and Laurent Mauvieux and P Heimann and C Chalas and E Clappier and Bruno Verhasselt and Yves Benoit and B D Moerloose and Bruce Poppe and Nadine Van Roy and K D Keersmaecker and Jan Cools and F Sigaux and J Soulier and Anne Hagemeijer and Anne De Paepe and Nicole Dastugue and R Berger and Frank Speleman},\n title = {Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRbeta-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique.},\n journal = {Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K}, \n abstract = {Recently, we and others described a new chromosomal rearrangement, that is, inv(7)(p15q34) and t(7;7)(p15;q34) involving the T-cell receptor beta (TCRbeta) (7q34) and the HOXA gene locus (7p15) in 5\\% of T-cell acute lymphoblastic leukemia (T-ALL) patients leading to transcriptional activation of especially HOXA10. To further address the clinical, immunophenotypical and molecular genetic findings of this chromosomal aberration, we studied 330 additional T-ALLs. This revealed TCRbeta-HOXA rearrangements in five additional patients, which brings the total to 14 cases in 424 patients (3.3\\%). Real-time quantitative PCR analysis for HOXA10 gene expression was performed in 170 T-ALL patients and detected HOXA10 overexpression in 25.2\\% of cases including all the cases with a TCRbeta-HOXA rearrangement (8.2\\%). In contrast, expression of the short HOXA10 transcript, HOXA10b, was almost exclusively found in the TCRbeta-HOXA rearranged cases, suggesting a specific role for the HOXA10b short transcript in TCRbeta-HOXA-mediated oncogenesis. Other molecular and/or cytogenetic aberrations frequently found in subtypes of T-ALL (SIL-TAL1, CALM-AF10, HOX11, HOX11L2) were not detected in the TCRbeta-HOXA rearranged cases except for deletion 9p21 and NOTCH1 activating mutations, which were present in 64 and 67\\%, respectively. In conclusion, this study defines TCRbeta-HOXA rearranged T-ALLs as a distinct cytogenetic subgroup by clinical, immunophenotypical and molecular genetic characteristics.},\n issn = {0887-6924},\n month = {January},\n pages = {121--8},\n volume = {21},\n number = {1},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/17039236} ,\n year = {2007}\n}\n\n\n","author_short":["Cauwelier, B.","Cavé, H.","Gervais, C","Lessard, M.","Barin, C","Perot, C","den Akker, J V.","Mugneret, F","Charrin, C","Pagès, M P","Grégoire, M J","Jonveaux, P","Lafage-Pochitaloff, M.","Mozzicconacci, M J","Terré, C","Luquet, I","Cornillet-Lefebvre, P","Laurence, B","Plessis, G","Lefebvre, C","Leroux, D","Antoine-Poirel, H","Graux, C.","Mauvieux, L.","Heimann, P","Chalas, C","Clappier, E","Verhasselt, B.","Benoit, Y.","Moerloose, B D","Poppe, B.","Roy, N. V.","Keersmaecker, K D","Cools, J.","Sigaux, F","Soulier, J","Hagemeijer, A.","Paepe, A. 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