@article{caverzan_new_2021,
	title = {A new phytocosmetic preparation from \textit{{Thymus} vulgaris} stimulates adipogenesis and controls skin aging process: {In} vitro studies and topical effects in a double‐blind placebo‐controlled clinical trial},
	volume = {20},
	issn = {1473-2130, 1473-2165},
	shorttitle = {A new phytocosmetic preparation from \textit{{Thymus} vulgaris} stimulates adipogenesis and controls skin aging process},
	url = {https://onlinelibrary.wiley.com/doi/10.1111/jocd.13818},
	doi = {10.1111/jocd.13818},
	abstract = {Abstract
            
              Background
              The use of the injectable products for soft tissue augmentation and treatment of skin aging is an uncomfortable, invasive and related to several complications, and chronic reactions, mainly after long‐term application. Efforts to develop new topically active anti‐aging products with fewer adverse effects are a huge challenge that should be faced.
            
            
              Aims
              
                We evaluated the anti‐aging effects of a phytocosmetic preparation containing
                Thymus vulgaris
                associated with lecithin (ThymLec) on the facial wrinkles, expression lines, and face oval remodeling using a double‐blind placebo‐controlled clinical trial and in vitro cell culture assays.
              
            
            
              Methods
              A clinical trial was conducted to evaluate the effects of ThymLec 2\% on the area, length, and depth of the perioral and crow's feet wrinkles, nasolabial and smile lines, as well as face oval remodeling in female volunteers using a sophisticated Bio3D Structured‐light Scanner. In the in vitro studies using 3T3‐L1 mouse embryonic fibroblasts, adiponectin was measured by immunoenzymatic assay, adipogenesis by the AdipoRed reagent method, and the PPAR‐γ expression by RT‐PCR analysis.
            
            
              Results
              Topical treatment with ThymLec 2\% reduced facial wrinkles and expression lines promoting a face oval remodeling. In the in vitro studies, ThymLec upregulated the PPAR‐γ expression increasing adiponectin production and stimulating the adipogenesis process.
            
            
              Conclusions
              
                The phytocosmetic preparation containing
                Thymus vulgaris
                and lecithin is an innovative and safe topical anti‐aging product promoting fat tissue augmentation by adipogenesis stimulation
                via
                the upregulation of PPAR‐γ expression and adiponectin production.},
	language = {en},
	number = {7},
	urldate = {2024-10-13},
	journal = {Journal of Cosmetic Dermatology},
	author = {Caverzan, Jeanifer and Mussi, Lilian and Sufi, Bianca and Padovani, Giovana and Nazato, Lucas and Camargo, Flavio B. and Magalhães, Wagner V. and Di Stasi, Luiz C.},
	month = jul,
	year = {2021},
	pages = {2190--2202},
}

{"_id":"74jwRDjPn9X8HgzQc","bibbaseid":"caverzan-mussi-sufi-padovani-nazato-camargo-magalhes-distasi-anewphytocosmeticpreparationfromithymusvulgarisistimulatesadipogenesisandcontrolsskinagingprocessinvitrostudiesandtopicaleffectsinadoubleblindplacebocontrolledclinicaltrial-2021","author_short":["Caverzan, J.","Mussi, L.","Sufi, B.","Padovani, G.","Nazato, L.","Camargo, F. B.","Magalhães, W. V.","Di Stasi, L. C."],"bibdata":{"bibtype":"article","type":"article","title":"A new phytocosmetic preparation from <i>Thymus vulgaris</i> stimulates adipogenesis and controls skin aging process: In vitro studies and topical effects in a double‐blind placebo‐controlled clinical trial","volume":"20","issn":"1473-2130, 1473-2165","shorttitle":"A new phytocosmetic preparation from <i>Thymus vulgaris</i> stimulates adipogenesis and controls skin aging process","url":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.13818","doi":"10.1111/jocd.13818","abstract":"Abstract Background The use of the injectable products for soft tissue augmentation and treatment of skin aging is an uncomfortable, invasive and related to several complications, and chronic reactions, mainly after long‐term application. Efforts to develop new topically active anti‐aging products with fewer adverse effects are a huge challenge that should be faced. Aims We evaluated the anti‐aging effects of a phytocosmetic preparation containing Thymus vulgaris associated with lecithin (ThymLec) on the facial wrinkles, expression lines, and face oval remodeling using a double‐blind placebo‐controlled clinical trial and in vitro cell culture assays. Methods A clinical trial was conducted to evaluate the effects of ThymLec 2% on the area, length, and depth of the perioral and crow's feet wrinkles, nasolabial and smile lines, as well as face oval remodeling in female volunteers using a sophisticated Bio3D Structured‐light Scanner. In the in vitro studies using 3T3‐L1 mouse embryonic fibroblasts, adiponectin was measured by immunoenzymatic assay, adipogenesis by the AdipoRed reagent method, and the PPAR‐γ expression by RT‐PCR analysis. Results Topical treatment with ThymLec 2% reduced facial wrinkles and expression lines promoting a face oval remodeling. In the in vitro studies, ThymLec upregulated the PPAR‐γ expression increasing adiponectin production and stimulating the adipogenesis process. Conclusions The phytocosmetic preparation containing Thymus vulgaris and lecithin is an innovative and safe topical anti‐aging product promoting fat tissue augmentation by adipogenesis stimulation via the upregulation of PPAR‐γ expression and adiponectin production.","language":"en","number":"7","urldate":"2024-10-13","journal":"Journal of Cosmetic Dermatology","author":[{"propositions":[],"lastnames":["Caverzan"],"firstnames":["Jeanifer"],"suffixes":[]},{"propositions":[],"lastnames":["Mussi"],"firstnames":["Lilian"],"suffixes":[]},{"propositions":[],"lastnames":["Sufi"],"firstnames":["Bianca"],"suffixes":[]},{"propositions":[],"lastnames":["Padovani"],"firstnames":["Giovana"],"suffixes":[]},{"propositions":[],"lastnames":["Nazato"],"firstnames":["Lucas"],"suffixes":[]},{"propositions":[],"lastnames":["Camargo"],"firstnames":["Flavio","B."],"suffixes":[]},{"propositions":[],"lastnames":["Magalhães"],"firstnames":["Wagner","V."],"suffixes":[]},{"propositions":[],"lastnames":["Di","Stasi"],"firstnames":["Luiz","C."],"suffixes":[]}],"month":"July","year":"2021","pages":"2190–2202","bibtex":"@article{caverzan_new_2021,\n\ttitle = {A new phytocosmetic preparation from \\textit{{Thymus} vulgaris} stimulates adipogenesis and controls skin aging process: {In} vitro studies and topical effects in a double‐blind placebo‐controlled clinical trial},\n\tvolume = {20},\n\tissn = {1473-2130, 1473-2165},\n\tshorttitle = {A new phytocosmetic preparation from \\textit{{Thymus} vulgaris} stimulates adipogenesis and controls skin aging process},\n\turl = {https://onlinelibrary.wiley.com/doi/10.1111/jocd.13818},\n\tdoi = {10.1111/jocd.13818},\n\tabstract = {Abstract\n \n Background\n The use of the injectable products for soft tissue augmentation and treatment of skin aging is an uncomfortable, invasive and related to several complications, and chronic reactions, mainly after long‐term application. Efforts to develop new topically active anti‐aging products with fewer adverse effects are a huge challenge that should be faced.\n \n \n Aims\n \n We evaluated the anti‐aging effects of a phytocosmetic preparation containing\n Thymus vulgaris\n associated with lecithin (ThymLec) on the facial wrinkles, expression lines, and face oval remodeling using a double‐blind placebo‐controlled clinical trial and in vitro cell culture assays.\n \n \n \n Methods\n A clinical trial was conducted to evaluate the effects of ThymLec 2\\% on the area, length, and depth of the perioral and crow's feet wrinkles, nasolabial and smile lines, as well as face oval remodeling in female volunteers using a sophisticated Bio3D Structured‐light Scanner. In the in vitro studies using 3T3‐L1 mouse embryonic fibroblasts, adiponectin was measured by immunoenzymatic assay, adipogenesis by the AdipoRed reagent method, and the PPAR‐γ expression by RT‐PCR analysis.\n \n \n Results\n Topical treatment with ThymLec 2\\% reduced facial wrinkles and expression lines promoting a face oval remodeling. In the in vitro studies, ThymLec upregulated the PPAR‐γ expression increasing adiponectin production and stimulating the adipogenesis process.\n \n \n Conclusions\n \n The phytocosmetic preparation containing\n Thymus vulgaris\n and lecithin is an innovative and safe topical anti‐aging product promoting fat tissue augmentation by adipogenesis stimulation\n via\n the upregulation of PPAR‐γ expression and adiponectin production.},\n\tlanguage = {en},\n\tnumber = {7},\n\turldate = {2024-10-13},\n\tjournal = {Journal of Cosmetic Dermatology},\n\tauthor = {Caverzan, Jeanifer and Mussi, Lilian and Sufi, Bianca and Padovani, Giovana and Nazato, Lucas and Camargo, Flavio B. and Magalhães, Wagner V. and Di Stasi, Luiz C.},\n\tmonth = jul,\n\tyear = {2021},\n\tpages = {2190--2202},\n}\n\n\n\n","author_short":["Caverzan, J.","Mussi, L.","Sufi, B.","Padovani, G.","Nazato, L.","Camargo, F. B.","Magalhães, W. V.","Di Stasi, L. C."],"key":"caverzan_new_2021","id":"caverzan_new_2021","bibbaseid":"caverzan-mussi-sufi-padovani-nazato-camargo-magalhes-distasi-anewphytocosmeticpreparationfromithymusvulgarisistimulatesadipogenesisandcontrolsskinagingprocessinvitrostudiesandtopicaleffectsinadoubleblindplacebocontrolledclinicaltrial-2021","role":"author","urls":{"Paper":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.13818"},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/FRGBergamini","dataSources":["o2mL7kG99iAQPpNRJ"],"keywords":[],"search_terms":["new","phytocosmetic","preparation","thymus","vulgaris","stimulates","adipogenesis","controls","skin","aging","process","vitro","studies","topical","effects","double","blind","placebo","controlled","clinical","trial","caverzan","mussi","sufi","padovani","nazato","camargo","magalhães","di stasi"],"title":"A new phytocosmetic preparation from <i>Thymus vulgaris</i> stimulates adipogenesis and controls skin aging process: In vitro studies and topical effects in a double‐blind placebo‐controlled clinical trial","year":2021}