Vitamin d deficiency as risk factor for severity of acute lower respiratory tract infections. Cazan C., Neamtu M.L., Neamtu B.M., Bodrug N., & Istrate V. 2016.
abstract   bibtex   
Background and aims Vitamin D deficiency is highly prevalent and it is declared a public health problem for children worldwide. The aim of this study was to investigate the potential relationship between vitamin D deficiency and severity of lower respiratory tract infections. Methods Children aged six to eighteen months, admitted in Pediatric Clinic from September 2015 to March 2016 for lower respiratory tract infection were recruited for the study. Criteria for hospitalization include low oxygen saturation (\textless90-92%), moderate to severe respiratory distress, deshydration and presence of apnea. We measured plasma 25- hydroxyvitamin D concentrations in a random sample of 53 patients. Baseline vitamin D status was classified as deficient level less than 20 ng/mL, insufficient (20-30 ng/mL) or sufficient \textgreater30 ng/mL. Results The prevalence of vitamin D deficiency was 21% and 48% of patients were vitamin D insufficient. Mean +/- SD serum levels of vitamin D were significantly higher (p\textless 0.05) in patients with moderate disease (26.3+/-5.2 ng/mL) compared with those with severe disease (14.5+/-5.9 ng/ mL). Vitamin D deficiency was associated with increased risk of severe bronchiolitis and lower respiratory tract infection in the first year of life. Vitamin D deficiency was associated with a longer length of stay. Vitamin D insufficiency was most commonly diagnosed in the winter / spring season (44%). Conclusions Vitamin D deficiency is related to increased risk and greater severity of respiratory infections. Current recommendations for vitamin D supplementation should be followed especially in infants at high risk.
@misc{cazan_c._vitamin_2016,
	title = {Vitamin d deficiency as risk factor for severity of acute lower respiratory tract infections},
	abstract = {Background and aims Vitamin D deficiency is highly prevalent and it is declared a public health problem for children worldwide. The aim of this study was to investigate the potential relationship between vitamin D deficiency and severity of lower respiratory tract infections. Methods Children aged six to eighteen months, admitted in Pediatric Clinic from September 2015 to March 2016 for lower respiratory tract infection were recruited for the study. Criteria for hospitalization include low oxygen saturation ({\textless}90-92\%), moderate to severe respiratory distress, deshydration and presence of apnea. We measured plasma 25- hydroxyvitamin D concentrations in a random sample of 53 patients. Baseline vitamin D status was classified as deficient level less than 20 ng/mL, insufficient (20-30 ng/mL) or sufficient {\textgreater}30 ng/mL. Results The prevalence of vitamin D deficiency was 21\% and 48\% of patients were vitamin D insufficient. Mean +/- SD serum levels of vitamin D were significantly higher (p{\textless} 0.05) in patients with moderate disease (26.3+/-5.2 ng/mL) compared with those with severe disease (14.5+/-5.9 ng/ mL). Vitamin D deficiency was associated with increased risk of severe bronchiolitis and lower respiratory tract infection in the first year of life. Vitamin D deficiency was associated with a longer length of stay. Vitamin D insufficiency was most commonly diagnosed in the winter / spring season (44\%). Conclusions Vitamin D deficiency is related to increased risk and greater severity of respiratory infections. Current recommendations for vitamin D supplementation should be followed especially in infants at high risk.},
	journal = {European Journal of Pediatrics},
	author = {{Cazan C.} and {Neamtu M.L.} and {Neamtu B.M.} and {Bodrug N.} and {Istrate V.}},
	year = {2016},
	keywords = {*lower respiratory tract infection, *risk factor, *vitamin D deficiency, 25 hydroxyvitamin D, Child, apnea monitoring, bronchiolitis, clinical trial, controlled study, dehydration, diagnosis, hospitalization, human, human tissue, infant, length of stay, major clinical study, oxygen saturation, pediatric hospital, plasma, prevalence, random sample, respiratory distress, spring, winter}
}

Downloads: 0