Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization. Cele, S., Jackson, L., Khoury, D. S, Khan, K., Moyo-Gwete, T., Tegally, H., San, J. E., Cromer, D., Scheepers, C., Amoako, D. G, Karim, F., Bernstein, M., Lustig, G., Archary, D., Smith, M., Ganga, Y., Jule, Z., Reedoy, K., Hwa, S., Giandhari, J., Blackburn, J. M, Gosnell, B. I, Abdool Karim, S. S, Hanekom, W., NGS-SA, COMMIT-KZN Team, von Gottberg, A., Bhiman, J. N, Lessells, R. J, Moosa, M. S, Davenport, M. P, de Oliveira, T., Moore, P. L, & Sigal, A. Nature, 602:654–656, Nature Publishing Group, dec, 2022. ![Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The emergence of Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. We investigated whether Omicron escapes antibody neutralization in South Africans vaccinated with Pfizer BNT162b2. We also investigated if Omicron requires the ACE2 receptor to infect cells. We isolated and sequence confirmed live Omicron virus from an infected person in South Africa and compared plasma neutralization of Omicron relative to an ancestral SARS-CoV-2 strain, observing that Omicron still required ACE2 to infect. For neutralization, blood samples were taken soon after vaccination from participants who were vaccinated and previously infected or vaccinated with no evidence of previous infection. Neutralization of ancestral virus was much higher in infected and vaccinated versus vaccinated only participants but both groups showed a 22-fold escape from vaccine elicited neutralization by the Omicron variant. However, in the previously infected and vaccinated group, the level of residual neutralization of Omicron was similar to the level of neutralization of ancestral virus observed in the vaccination only group. These data support the notion that, provided high neutralization capacity is elicited by vaccination/boosting approaches, reasonable effectiveness against Omicron may be maintained.
@article{Cele2021,
abstract = {The emergence of Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. We investigated whether Omicron escapes antibody neutralization in South Africans vaccinated with Pfizer BNT162b2. We also investigated if Omicron requires the ACE2 receptor to infect cells. We isolated and sequence confirmed live Omicron virus from an infected person in South Africa and compared plasma neutralization of Omicron relative to an ancestral SARS-CoV-2 strain, observing that Omicron still required ACE2 to infect. For neutralization, blood samples were taken soon after vaccination from participants who were vaccinated and previously infected or vaccinated with no evidence of previous infection. Neutralization of ancestral virus was much higher in infected and vaccinated versus vaccinated only participants but both groups showed a 22-fold escape from vaccine elicited neutralization by the Omicron variant. However, in the previously infected and vaccinated group, the level of residual neutralization of Omicron was similar to the level of neutralization of ancestral virus observed in the vaccination only group. These data support the notion that, provided high neutralization capacity is elicited by vaccination/boosting approaches, reasonable effectiveness against Omicron may be maintained.},
author = {Cele, Sandile and Jackson, Laurelle and Khoury, David S and Khan, Khadija and Moyo-Gwete, Thandeka and Tegally, Houriiyah and San, James Emmanuel and Cromer, Deborah and Scheepers, Cathrine and Amoako, Daniel G and Karim, Farina and Bernstein, Mallory and Lustig, Gila and Archary, Derseree and Smith, Muneerah and Ganga, Yashica and Jule, Zesuliwe and Reedoy, Kajal and Hwa, Shi-Hsia and Giandhari, Jennifer and Blackburn, Jonathan M and Gosnell, Bernadett I and {Abdool Karim}, Salim S and Hanekom, Willem and NGS-SA and {COMMIT-KZN Team} and von Gottberg, Anne and Bhiman, Jinal N and Lessells, Richard J and Moosa, Mahomed-Yunus S and Davenport, Miles P and de Oliveira, Tulio and Moore, Penny L and Sigal, Alex},
doi = {10.1038/s41586-021-04387-1},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Cele et al. - 2022 - Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization.pdf:pdf},
issn = {1476-4687},
journal = {Nature},
keywords = {2,Antimicrobial responses,CoV,OA,SARS,fund{\_}not{\_}ack,original},
mendeley-tags = {OA,fund{\_}not{\_}ack,original},
month = {dec},
pages = {654--656},
pmid = {35016196},
publisher = {Nature Publishing Group},
title = {{Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization}},
url = {https://www.nature.com/articles/s41586-021-04387-1},
volume = {602},
year = {2022}
}
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