A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics. Chaillon, A., Hoenigl, M., Mehta, S. R., Weibel, N., Little, S. J., & Smith, D. M. Scientific Reports, 6:28707, 2016. doi abstract bibtex It remains unclear what proportions of HIV-infected and uninfected people should receive effective antiretroviral therapy (ART) to control local HIV epidemics. We developed a flexible model to evaluate the impact of treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP) on HIV incidence in local communities. We evaluated this tool for determining what TasP and PrEP targets are needed to substantially reduce the HIV epidemic in San Diego, which is predominately comprised of men who have sex with men. By increasing the proportion of HIV-infected individuals on ART from 30% to 50%, 686 new infections would be prevented over five years in San Diego. By providing PrEP to 30% of MSM to the age group that account for 90% of local HIV incident cases (21-52 years), we could prevent 433 infections over five years. When combining these initiatives, a PrEP coverage rate of 40% and TasP coverage rate of 34% would be expected to decrease the number of new infections by over half in one year. This online tool is designed to help local public health planners and policy makers to estimate program outcomes and costs that may lead to better control of their local HIV epidemics.
@article{chaillon_practical_2016,
title = {A practical online tool to estimate antiretroviral coverage for {HIV} infected and susceptible populations needed to reduce local {HIV} epidemics},
volume = {6},
issn = {2045-2322},
doi = {10.1038/srep28707},
abstract = {It remains unclear what proportions of HIV-infected and uninfected people should receive effective antiretroviral therapy (ART) to control local HIV epidemics. We developed a flexible model to evaluate the impact of treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP) on HIV incidence in local communities. We evaluated this tool for determining what TasP and PrEP targets are needed to substantially reduce the HIV epidemic in San Diego, which is predominately comprised of men who have sex with men. By increasing the proportion of HIV-infected individuals on ART from 30\% to 50\%, 686 new infections would be prevented over five years in San Diego. By providing PrEP to 30\% of MSM to the age group that account for 90\% of local HIV incident cases (21-52 years), we could prevent 433 infections over five years. When combining these initiatives, a PrEP coverage rate of 40\% and TasP coverage rate of 34\% would be expected to decrease the number of new infections by over half in one year. This online tool is designed to help local public health planners and policy makers to estimate program outcomes and costs that may lead to better control of their local HIV epidemics.},
language = {eng},
journal = {Scientific Reports},
author = {Chaillon, Antoine and Hoenigl, Martin and Mehta, Sanjay R. and Weibel, Nadir and Little, Susan J. and Smith, Davey M.},
year = {2016},
pmid = {27337983},
pmcid = {PMC4919622},
keywords = {Adult, Age Factors, Anti-Retroviral Agents, California, Disease Susceptibility, Epidemics, HIV Infections, Health Policy, Homosexuality, Male, Humans, Incidence, Internet, Male, Middle Aged, Models, Biological, Pre-Exposure Prophylaxis, Risk-Taking, Sensitivity and Specificity, Sexual Behavior, Young Adult},
pages = {28707},
}
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