Modeling and live imaging of mechanical instabilities in the zebrafish aorta during hematopoiesis. Chalin, D., Bureau, C., Parmeggiani, A., Rochal, S., Kissa, K., & Golushko, I. Scientific Reports, 11(1):9316, April, 2021. ![Modeling and live imaging of mechanical instabilities in the zebrafish aorta during hematopoiesis [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Abstract All blood cells originate from hematopoietic stem/progenitor cells (HSPCs). HSPCs are formed from endothelial cells (ECs) of the dorsal aorta (DA), via endothelial-to-hematopoietic transition (EHT). The zebrafish is a primary model organism to study the process in vivo. While the role of mechanical stress in controlling gene expression promoting cell differentiation is actively investigated, mechanisms driving shape changes of the DA and individual ECs remain poorly understood. We address this problem by developing a new DA micromechanical model and applying it to experimental data on zebrafish morphogenesis. The model considers the DA as an isotropic tubular membrane subjected to hydrostatic blood pressure and axial stress. The DA evolution is described as a movement in the dimensionless controlling parameters space: normalized hydrostatic pressure and axial stress. We argue that HSPC production is accompanied by two mechanical instabilities arising in the system due to the plane stress in the DA walls and show how a complex interplay between mechanical forces in the system drives the emerging morphological changes.
@article{chalin_modeling_2021,
title = {Modeling and live imaging of mechanical instabilities in the zebrafish aorta during hematopoiesis},
volume = {11},
issn = {2045-2322},
url = {https://www.nature.com/articles/s41598-021-88667-w},
doi = {10.1038/s41598-021-88667-w},
abstract = {Abstract
All blood cells originate from hematopoietic stem/progenitor cells (HSPCs). HSPCs are formed from endothelial cells (ECs) of the dorsal aorta (DA), via endothelial-to-hematopoietic transition (EHT). The zebrafish is a primary model organism to study the process in vivo. While the role of mechanical stress in controlling gene expression promoting cell differentiation is actively investigated, mechanisms driving shape changes of the DA and individual ECs remain poorly understood. We address this problem by developing a new DA micromechanical model and applying it to experimental data on zebrafish morphogenesis. The model considers the DA as an isotropic tubular membrane subjected to hydrostatic blood pressure and axial stress. The DA evolution is described as a movement in the dimensionless controlling parameters space: normalized hydrostatic pressure and axial stress. We argue that HSPC production is accompanied by two mechanical instabilities arising in the system due to the plane stress in the DA walls and show how a complex interplay between mechanical forces in the system drives the emerging morphological changes.},
language = {en},
number = {1},
urldate = {2023-11-10},
journal = {Scientific Reports},
author = {Chalin, Dmitrii and Bureau, Charlotte and Parmeggiani, Andrea and Rochal, Sergei and Kissa, Karima and Golushko, Ivan},
month = apr,
year = {2021},
pages = {9316},
file = {Полный текст:C\:\\Users\\aleks\\Zotero\\storage\\PXM8A3B8\\Chalin и др. - 2021 - Modeling and live imaging of mechanical instabilit.pdf:application/pdf},
}
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While the role of mechanical stress in controlling gene expression promoting cell differentiation is actively investigated, mechanisms driving shape changes of the DA and individual ECs remain poorly understood. We address this problem by developing a new DA micromechanical model and applying it to experimental data on zebrafish morphogenesis. The model considers the DA as an isotropic tubular membrane subjected to hydrostatic blood pressure and axial stress. The DA evolution is described as a movement in the dimensionless controlling parameters space: normalized hydrostatic pressure and axial stress. 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