Probing the Interactions of Nanoparticles with Biological Systems. Chan, W. C. W. The FASEB Journal, 23(S1):69.1–69.1, 2009. _eprint: https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fasebj.23.1_supplement.69.1![Probing the Interactions of Nanoparticles with Biological Systems [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Nanoparticles have many applications in biomedical imaging, clinical diagnostics and therapeutics. Strategies that can reproducibly prepare colloidal nanoparticles of a wide range of geometries with a tight size distribution have been achieved and unique size and shape dependent optical, magnetic, electrical, and biological properties have been discovered. In spite of what has been achieved so far, a complete understanding of the interactions of cells with nanoparticles at the molecular level is lacking. This has led to the inability to rationally design nanoparticles for biomedical applications or has led to the inability to establish a definitive conclusion on the toxicity of nanomaterials. This presentation will focus on recent findings of the size and shape dependent interactions of nanoparticles with receptors on the cell surface. Specifically, data pertaining to the effect of antibody-coated gold and silver nanoparticle size on regulating membrane receptor internalization and their subsequent signaling will be discussed. The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity.
@article{chan_probing_2009,
title = {Probing the {Interactions} of {Nanoparticles} with {Biological} {Systems}},
volume = {23},
issn = {1530-6860},
url = {http://onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.23.1_supplement.69.1},
doi = {10.1096/fasebj.23.1_supplement.69.1},
abstract = {Nanoparticles have many applications in biomedical imaging, clinical diagnostics and therapeutics. Strategies that can reproducibly prepare colloidal nanoparticles of a wide range of geometries with a tight size distribution have been achieved and unique size and shape dependent optical, magnetic, electrical, and biological properties have been discovered. In spite of what has been achieved so far, a complete understanding of the interactions of cells with nanoparticles at the molecular level is lacking. This has led to the inability to rationally design nanoparticles for biomedical applications or has led to the inability to establish a definitive conclusion on the toxicity of nanomaterials. This presentation will focus on recent findings of the size and shape dependent interactions of nanoparticles with receptors on the cell surface. Specifically, data pertaining to the effect of antibody-coated gold and silver nanoparticle size on regulating membrane receptor internalization and their subsequent signaling will be discussed. The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity.},
language = {en},
number = {S1},
urldate = {2021-11-06},
journal = {The FASEB Journal},
author = {Chan, Warren C. W.},
year = {2009},
note = {\_eprint: https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fasebj.23.1\_supplement.69.1},
pages = {69.1--69.1},
file = {Snapshot:files/2159/fasebj.23.1_supplement.69.html:text/html},
}
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