Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers. Chang, E. T. & Delzell, E. Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes, 51(6):402–434, 2016. doi abstract bibtex This systematic review and meta-analysis rigorously examines the relationship between glyphosate exposure and risk of lymphohematopoietic cancer (LHC) including NHL, Hodgkin lymphoma (HL), multiple myeloma (MM), and leukemia. Meta-relative risks (meta-RRs) were positive and marginally statistically significant for the association between any versus no use of glyphosate and risk of NHL (meta-RR = 1.3, 95% confidence interval (CI) = 1.0-1.6, based on six studies) and MM (meta-RR = 1.4, 95% CI = 1.0-1.9; four studies). Associations were statistically null for HL (meta-RR = 1.1, 95% CI = 0.7-1.6; two studies), leukemia (meta-RR = 1.0, 95% CI = 0.6-1.5; three studies), and NHL subtypes except B-cell lymphoma (two studies each). Bias and confounding may account for observed associations. Meta-analysis is constrained by few studies and a crude exposure metric, while the overall body of literature is methodologically limited and findings are not strong or consistent. Thus, a causal relationship has not been established between glyphosate exposure and risk of any type of LHC.
@article{chang_systematic_2016,
title = {Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers},
volume = {51},
issn = {1532-4109},
doi = {10.1080/03601234.2016.1142748},
abstract = {This systematic review and meta-analysis rigorously examines the relationship between glyphosate exposure and risk of lymphohematopoietic cancer (LHC) including NHL, Hodgkin lymphoma (HL), multiple myeloma (MM), and leukemia. Meta-relative risks (meta-RRs) were positive and marginally statistically significant for the association between any versus no use of glyphosate and risk of NHL (meta-RR = 1.3, 95\% confidence interval (CI) = 1.0-1.6, based on six studies) and MM (meta-RR = 1.4, 95\% CI = 1.0-1.9; four studies). Associations were statistically null for HL (meta-RR = 1.1, 95\% CI = 0.7-1.6; two studies), leukemia (meta-RR = 1.0, 95\% CI = 0.6-1.5; three studies), and NHL subtypes except B-cell lymphoma (two studies each). Bias and confounding may account for observed associations. Meta-analysis is constrained by few studies and a crude exposure metric, while the overall body of literature is methodologically limited and findings are not strong or consistent. Thus, a causal relationship has not been established between glyphosate exposure and risk of any type of LHC.},
language = {eng},
number = {6},
journal = {Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes},
author = {Chang, Ellen T. and Delzell, Elizabeth},
year = {2016},
pmid = {27015139},
pmcid = {PMC4866614},
keywords = {Glycine, Glyphosate, Herbicides, Hodgkin Disease, Hodgkin lymphoma, Humans, Leukemia, Multiple Myeloma, Neoplasms, Risk Factors, hematologic malignancies, herbicides, leukemia, meta-analysis, multiple myeloma, non-Hodgkin lymphoma},
pages = {402--434},
}
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Associations were statistically null for HL (meta-RR = 1.1, 95% CI = 0.7-1.6; two studies), leukemia (meta-RR = 1.0, 95% CI = 0.6-1.5; three studies), and NHL subtypes except B-cell lymphoma (two studies each). Bias and confounding may account for observed associations. Meta-analysis is constrained by few studies and a crude exposure metric, while the overall body of literature is methodologically limited and findings are not strong or consistent. Thus, a causal relationship has not been established between glyphosate exposure and risk of any type of LHC.","language":"eng","number":"6","journal":"Journal of Environmental Science and Health. Part. 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