Changing residue 338 in human factor IX from arginine to Alanine causes an increase in catalytic activity. Chang, J., Jin, J., Lollar, P, Bode, W, Brandstetter, H, Hamaguchi, N, Straight, D., & Stafford, D. Journal of Biological Chemistry, 273(20):12089-12094, 1998.
bibtex   
@Article{Chang1998,
  Title                    = {Changing residue 338 in human factor IX from arginine to Alanine causes an increase in catalytic activity},
  Author                   = {Chang, JL and Jin, JP and Lollar, P and Bode, W and Brandstetter, H and Hamaguchi, N and Straight, DL and Stafford, DW},
  Journal                  = {Journal of Biological Chemistry},
  Year                     = {1998},
  Number                   = {20},
  Pages                    = {12089-12094},
  Volume                   = {273}
}
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