{"_id":"Djbc26Ff7bvtZ8uEm","bibbaseid":"chang-vong-yamamoto-tanaka-prodrugactivationbygoldartificialmetalloenzymecatalyzedsynthesisofphenanthridiniumderivativesviahydroamination-2021","author_short":["Chang, T. C.","Vong, K.","Yamamoto, T.","Tanaka, K."],"bibdata":{"bibtype":"article","type":"article","title":"Prodrug Activation by Gold Artificial Metalloenzyme-Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination","volume":"60","issn":"15213773","doi":"10.1002/anie.202100369","abstract":"An emerging approach in the field of targeted drug delivery is the establishment of abiotic metal-triggered prodrug mechanisms that can control the release of bioactive drugs. Currently, the design of prodrugs that use abiotic metals as a trigger relies heavily on uncaging strategies. Here, we introduce a strategy based on the gold-catalyzed activation of a phenanthridinium-based prodrug via hydroamination under physiological conditions. To make the prodrug strategy biocompatible, a gold artificial metalloenzyme (ArM) based on human serum albumin, rather than the free gold metal complex, was used as a trigger for prodrug activation. The albumin-based gold ArM protected the catalytic activity of the bound gold metal even in the presence of up to 1 mM glutathione in vitro. The drug synthesized via the gold ArM exerted a therapeutic effect in cell-based assays, highlighting the potential usefulness of the gold ArM in anticancer applications.","number":"22","journal":"Angewandte Chemie - International Edition","author":[{"propositions":[],"lastnames":["Chang"],"firstnames":["Tsung","Che"],"suffixes":[]},{"propositions":[],"lastnames":["Vong"],"firstnames":["Kenward"],"suffixes":[]},{"propositions":[],"lastnames":["Yamamoto"],"firstnames":["Tomoya"],"suffixes":[]},{"propositions":[],"lastnames":["Tanaka"],"firstnames":["Katsunori"],"suffixes":[]}],"year":"2021","pmid":"33719151","keywords":"antitumor agents, gold catalysts, metalloenzymes, phenanthridinium, prodrugs","pages":"12446–12454","bibtex":"@article{chang_prodrug_2021,\n\ttitle = {Prodrug {Activation} by {Gold} {Artificial} {Metalloenzyme}-{Catalyzed} {Synthesis} of {Phenanthridinium} {Derivatives} via {Hydroamination}},\n\tvolume = {60},\n\tissn = {15213773},\n\tdoi = {10.1002/anie.202100369},\n\tabstract = {An emerging approach in the field of targeted drug delivery is the establishment of abiotic metal-triggered prodrug mechanisms that can control the release of bioactive drugs. Currently, the design of prodrugs that use abiotic metals as a trigger relies heavily on uncaging strategies. Here, we introduce a strategy based on the gold-catalyzed activation of a phenanthridinium-based prodrug via hydroamination under physiological conditions. To make the prodrug strategy biocompatible, a gold artificial metalloenzyme (ArM) based on human serum albumin, rather than the free gold metal complex, was used as a trigger for prodrug activation. The albumin-based gold ArM protected the catalytic activity of the bound gold metal even in the presence of up to 1 mM glutathione in vitro. The drug synthesized via the gold ArM exerted a therapeutic effect in cell-based assays, highlighting the potential usefulness of the gold ArM in anticancer applications.},\n\tnumber = {22},\n\tjournal = {Angewandte Chemie - International Edition},\n\tauthor = {Chang, Tsung Che and Vong, Kenward and Yamamoto, Tomoya and Tanaka, Katsunori},\n\tyear = {2021},\n\tpmid = {33719151},\n\tkeywords = {antitumor agents, gold catalysts, metalloenzymes, phenanthridinium, prodrugs},\n\tpages = {12446--12454},\n}\n\n\n\n","author_short":["Chang, T. C.","Vong, K.","Yamamoto, T.","Tanaka, K."],"key":"chang_prodrug_2021-1","id":"chang_prodrug_2021-1","bibbaseid":"chang-vong-yamamoto-tanaka-prodrugactivationbygoldartificialmetalloenzymecatalyzedsynthesisofphenanthridiniumderivativesviahydroamination-2021","role":"author","urls":{},"keyword":["antitumor agents","gold catalysts","metalloenzymes","phenanthridinium","prodrugs"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/FRGBergamini","dataSources":["o2mL7kG99iAQPpNRJ"],"keywords":["antitumor agents","gold catalysts","metalloenzymes","phenanthridinium","prodrugs"],"search_terms":["prodrug","activation","gold","artificial","metalloenzyme","catalyzed","synthesis","phenanthridinium","derivatives","via","hydroamination","chang","vong","yamamoto","tanaka"],"title":"Prodrug Activation by Gold Artificial Metalloenzyme-Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination","year":2021}