P156 Differential characteristics of patients with inflammatory bowel disease onset in paediatric age compared with patients diagnosed in adulthood: Results from the CAROUSEL study of GETECCU. Chaparro, M., Garre, A., Ricart, E., García-Sánchez, V., Taxonera, C., Mañosa, M., Vera Mendoza, I., Mínguez, M., Argüelles, F., De Castro Parga, L., Arroyo, M., López-San Román, A., Rivero Tirado, M., Guardiola, J., Arranz, M., D, M., Beltrán, B., Barrio, J., Riestra, S., García-Planella, E., Calvet, X., Alcaín, G., Sicilia, B., García, S., Esteve, M., Márquez, L., Fernández Salazar, L., Gutiérrez Casbas, A., Piqueras, M., Guerra, I., Calle, P., L, J., Hinojosa, J., Rodríguez, A., Aldeguer, X., García-Sepulcre, M., Bujanda, L., Martínez Montiel, P., Llorente Poyatos, R., Rodríguez Gutiérrez, C., Merino, O., Cabriada, J. L., Roncero, O., Romero Cara, P., Navarro-Llavat, M., Ber, Y., Madrigal, R., Van Domselaar, M., Barreiro-de Acosta, M., Llao, J., Ramos, L., Riera, J., Villarín, L., J, A., Rodríguez González, E., Malavés, H., M, J., Muñoz Villafranca, C., Almela, P., Charro, M., Ramírez de la Piscina, P., Sese, E., Abad Lacruz, Á, Khorrami, S., Alvarado, M., J, V., Legido Gil, J., Martínez, T., M, A., Pajares, R., Acevedo, J., García Herola, A., Hernández Villalba, L., Muñoz, E., Durán, N., T, M., Menacho, M., López, N., M, V., Retamero, M. D., Domènech, E., & Gisbert, J. P. Journal of Crohn's and Colitis, 12(supplement_1):S174–S176, 2018.
P156 Differential characteristics of patients with inflammatory bowel disease onset in paediatric age compared with patients diagnosed in adulthood: Results from the CAROUSEL study of GETECCU [link]Paper  doi  abstract   bibtex   
Background Population-based studies comparing the characteristics of paediatric IBD with IBD diagnosed in the adulthood are scarce. The aims of this study were (i) To compare the characteristics of IBD in patients diagnosed during childhood (≤16 years) with those from patients diagnosed in adulthood; (ii) to compare the incidence rate of initiation of immunosuppressants, biologic agents and surgery between both groups; and (iii) to evaluate the impact of the age at diagnosis on the initiation of immunosuppressants, biological agents and surgery. Methods IBD patients from the ENEIDA registry—a large prospectively maintained Spanish database promoted by the Spanish Working Group in Crohn’s and Colitis (GETECCU), were included. In order to minimise the heterogeneity in the management of IBD patients, the inclusion was limited to those diagnosed after 1998, when the fist biological agent was approved for IBD in Europe. Patients diagnosed at ≤16 years comprised the paediatric cohort (PC), and those diagnosed >16 years were the adult cohort (AC). The cumulative incidences of immunosuppressive therapy, biological therapy and surgery, were estimated using Kaplan–Meier curves, which were compared by the log-rank test. Cox-regression analysis was performed to identify potential predictive factors to receive immunosuppressants, biological agents or surgery. Results From 35925 patients, there were 1630 paediatric cases (4.5%) and from them, 56 (3.4%) were very-early-onset IBD (<6 years). Median follow-up was 91 months in the PC and 72 months in the AC. The proportion of Crohn’s disease (CD), ileocolonic involvement and inflammatory behaviour at diagnosis was higher in the PC (Table 1). View large Download slide View large Download slide In the multivariate analysis, after adjusting for gender, type of IBD, extra intestinal manifestations, family history and smoking habit, the PC was associated with higher risk of immunomodulator use (hazard ratio [HR] = 1.47, 95% confidence interval [95% CI] = 1.38–1.58) and higher probability of receiving biologic treatment (HR = 1.53, 95% CI = 1.42–1.66). However, paediatric IBD was not associated with higher risk of surgery (Table 2). View large Download slide View large Download slide Conclusions Paediatric IBD has differential characteristics in comparison with adult IBD. In addition, paediatric IBD seems to be associated with higher use of immunosuppressant and biologics during follow-up. Nevertheless, paediatric IBD is not associated with higher risk of surgery.
@article{chaparro_p156_2018,
	title = {P156 {Differential} characteristics of patients with inflammatory bowel disease onset in paediatric age compared with patients diagnosed in adulthood: {Results} from the {CAROUSEL} study of {GETECCU}},
	volume = {12},
	issn = {1873-9946},
	shorttitle = {P156 {Differential} characteristics of patients with inflammatory bowel disease onset in paediatric age compared with patients diagnosed in adulthood},
	url = {https://academic.oup.com/ecco-jcc/article/12/supplement_1/S174/4808227},
	doi = {10.1093/ecco-jcc/jjx180.283},
	abstract = {Background
      Population-based studies comparing the characteristics of paediatric IBD with IBD diagnosed in the adulthood are scarce. The aims of this study were (i) To compare the characteristics of IBD in patients diagnosed during childhood (≤16 years) with those from patients diagnosed in adulthood; (ii) to compare the incidence rate of initiation of immunosuppressants, biologic agents and surgery between both groups; and (iii) to evaluate the impact of the age at diagnosis on the initiation of immunosuppressants, biological agents and surgery.
    
    
      Methods
      IBD patients from the ENEIDA registry—a large prospectively maintained Spanish database promoted by the Spanish Working Group in Crohn’s and Colitis (GETECCU), were included. In order to minimise the heterogeneity in the management of IBD patients, the inclusion was limited to those diagnosed after 1998, when the fist biological agent was approved for IBD in Europe. Patients diagnosed at ≤16 years comprised the paediatric cohort (PC), and those diagnosed \&gt;16 years were the adult cohort (AC). The cumulative incidences of immunosuppressive therapy, biological therapy and surgery, were estimated using Kaplan–Meier curves, which were compared by the log-rank test. Cox-regression analysis was performed to identify potential predictive factors to receive immunosuppressants, biological agents or surgery.
    
    
      Results
      From 35925 patients, there were 1630 paediatric cases (4.5\%) and from them, 56 (3.4\%) were very-early-onset IBD (\&lt;6 years). Median follow-up was 91 months in the PC and 72 months in the AC. The proportion of Crohn’s disease (CD), ileocolonic involvement and inflammatory behaviour at diagnosis was higher in the PC (Table 1).
      
        
          
          
            View large
            Download slide
          
        
      
      
        
          
          
            View large
            Download slide
          
        
      
      In the multivariate analysis, after adjusting for gender, type of IBD, extra intestinal manifestations, family history and smoking habit, the PC was associated with higher risk of immunomodulator use (hazard ratio [HR] = 1.47, 95\% confidence interval [95\% CI] = 1.38–1.58) and higher probability of receiving biologic treatment (HR = 1.53, 95\% CI = 1.42–1.66). However, paediatric IBD was not associated with higher risk of surgery (Table 2).
      
        
          
          
            View large
            Download slide
          
        
      
      
        
          
          
            View large
            Download slide
          
        
      
    
    
      Conclusions
      Paediatric IBD has differential characteristics in comparison with adult IBD. In addition, paediatric IBD seems to be associated with higher use of immunosuppressant and biologics during follow-up. Nevertheless, paediatric IBD is not associated with higher risk of surgery.},
	language = {en},
	number = {supplement\_1},
	urldate = {2018-03-05},
	journal = {Journal of Crohn's and Colitis},
	author = {Chaparro, M. and Garre, A. and Ricart, E. and García-Sánchez, V. and Taxonera, C. and Mañosa, M. and Vera Mendoza, I. and Mínguez, M. and Argüelles, F. and De Castro Parga, L. and Arroyo, M. and López-San Román, A. and Rivero Tirado, M. and Guardiola, J. and Arranz, Martín and D, M. and Beltrán, B. and Barrio, J. and Riestra, S. and García-Planella, E. and Calvet, X. and Alcaín, G. and Sicilia, B. and García, S. and Esteve, M. and Márquez, L. and Fernández Salazar, L. and Gutiérrez Casbas, A. and Piqueras, M. and Guerra, I. and Calle, Pérez and L, J. and Hinojosa, J. and Rodríguez, A. and Aldeguer, X. and García-Sepulcre, M. and Bujanda, L. and Martínez Montiel, P. and Llorente Poyatos, R. and Rodríguez Gutiérrez, C. and Merino, O. and Cabriada, J. L. and Roncero, O. and Romero Cara, P. and Navarro-Llavat, M. and Ber, Y. and Madrigal, R. and Van Domselaar, M. and Barreiro-de Acosta, M. and Llao, J. and Ramos, L. and Riera, J. and Villarín, Lucendo and J, A. and Rodríguez González, E. and Malavés, Huguet and M, J. and Muñoz Villafranca, C. and Almela, P. and Charro, M. and Ramírez de la Piscina, P. and Sese, E. and Abad Lacruz, Á and Khorrami, S. and Alvarado, Morales and J, V. and Legido Gil, J. and Martínez, Trapero and M, A. and Pajares, R. and Acevedo, J. and García Herola, A. and Hernández Villalba, L. and Muñoz, E. and Durán, Novella and T, M. and Menacho, M. and López, Navas and M, V. and Retamero, M. D. and Domènech, E. and Gisbert, J. P.},
	year = {2018},
	keywords = {Article, Digestiu},
	pages = {S174--S176},
}
Downloads: 0
About
Documentation
Keywords
Search
Users
Terms and Conditions of Use
Privacy Policy
Sitemap
© BibBase.org 2021