Effect of monophosphoryl lipid A on host resistance to bacterial infection. Chase, J J, Kubey, W, Dulek, M H, Holmes, C J, Salit, M G, Pearson, F C, & Ribi, E Infection and Immunity, 53(3):711–712, September, 1986. Paper abstract bibtex The ability of monophosphoryl lipid A (MPLA) to enhance nonspecific host resistance to bacterial infections was studied. Mice were treated with MPLA prior to intraperitoneal challenge with Escherichia coli or Staphylococcus epidermidis. Animals received additional MPLA for 2 days postinfection, and survival rates were determined. Ten micrograms of MPLA per mouse significantly improved the survival of animals infected with either bacterial species. Dose-response studies showed significant MPLA-induced protection at doses of 6 micrograms/kg against E. coli challenge and 60 micrograms/kg against S. epidermidis challenge.
@article{chase_effect_1986,
title = {Effect of monophosphoryl lipid {A} on host resistance to bacterial infection.},
volume = {53},
issn = {0019-9567},
url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC260854/},
abstract = {The ability of monophosphoryl lipid A (MPLA) to enhance nonspecific host resistance to bacterial infections was studied. Mice were treated with MPLA prior to intraperitoneal challenge with Escherichia coli or Staphylococcus epidermidis. Animals received additional MPLA for 2 days postinfection, and survival rates were determined. Ten micrograms of MPLA per mouse significantly improved the survival of animals infected with either bacterial species. Dose-response studies showed significant MPLA-induced protection at doses of 6 micrograms/kg against E. coli challenge and 60 micrograms/kg against S. epidermidis challenge.},
number = {3},
journal = {Infection and Immunity},
author = {Chase, J J and Kubey, W and Dulek, M H and Holmes, C J and Salit, M G and Pearson, F C and Ribi, E},
month = sep,
year = {1986},
pmid = {3744562},
pmcid = {PMC260854},
pages = {711--712},
}
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