@article{chee_use_2009,
	title = {Use of a {T} cell interferon-gamma release assay to evaluate tuberculosis risk in newly qualified physicians in {Singapore} healthcare institutions},
	volume = {30},
	issn = {0899-823X},
	url = {http://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105417357&site=ehost-live},
	doi = {10.1086/599284},
	abstract = {BACKGROUND: Surveillance for latent tuberculosis in high-risk groups such as healthcare workers is limited by the nonspecificity of the tuberculin skin test (TST) in BCG-vaccinated individuals. The Mycobacterium tuberculosis antigen-specific interferon-gamma release assays (IGRAs) show promise for more accurate latent tuberculosis detection in such groups. OBJECTIVE: To compare the utility of an IGRA, the T-SPOT.TB assay, with that of the TST in healthcare workers with a high rate of BCG vaccination. METHODS: Two hundred seven medical students from 2 consecutive cohorts underwent the T-SPOT.TB test and the TST in their final year of study. Subjects with negative baseline test results underwent repeat testing after working for 1 year as junior physicians in Singapore's public hospitals. RESULTS: The baseline TST result was an induration 10 mm or greater in diameter in 177 of the 205 students who returned to have their TST results evaluated (86.3\%), while the baseline T-SPOT.TB assay result was positive in 9 (4.3\%) of the students. Repeat T-SPOT.TB testing in 182 baseline-negative subjects showed conversion in 9 (4.9\%). A repeat TST in 18 subjects with baseline-negative TST results did not reveal any TST result conversion. CONCLUSIONS: The high rate of positive baseline TST results in our BCG-vaccinated healthcare workers renders the TST unsuitable as a surveillance tool in this tuberculosis risk group. Use of an IGRA has enabled the detection and treatment of latent tuberculosis in this group. Our T-SPOT.TB conversion rate highlights the need for greater tuberculosis awareness and improved infection control practices in our healthcare institutions.},
	number = {9},
	journal = {Infection Control \& Hospital Epidemiology},
	author = {Chee, C. B. E. and Lim, L. K. Y. and Barkham, T. M. and Koh, D. R. and Lam, S. O. and Shen, L. and Wang, Y. T.},
	year = {2009},
	keywords = {Adult, BCG Vaccine, Chi Square Test, Data Analysis Software, Demography, Descriptive Statistics, Female, Fisher's Exact Test, Funding Source, Hospitals, Public, Human, Interferon-Gamma Release Tests -- Evaluation, Male, Physicians, Questionnaires, Self Report, Singapore, Students, Medical, T-Tests, Time Factors, Tuberculin Test, Tuberculosis -- Diagnosis -- Singapore},
	pages = {870--875},
}

{"_id":"GJMsBKzXHEfo3peST","bibbaseid":"chee-lim-barkham-koh-lam-shen-wang-useofatcellinterferongammareleaseassaytoevaluatetuberculosisriskinnewlyqualifiedphysiciansinsingaporehealthcareinstitutions-2009","authorIDs":[],"author_short":["Chee, C. B. E.","Lim, L. K. Y.","Barkham, T. M.","Koh, D. R.","Lam, S. O.","Shen, L.","Wang, Y. T."],"bibdata":{"bibtype":"article","type":"article","title":"Use of a T cell interferon-gamma release assay to evaluate tuberculosis risk in newly qualified physicians in Singapore healthcare institutions","volume":"30","issn":"0899-823X","url":"http://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105417357&site=ehost-live","doi":"10.1086/599284","abstract":"BACKGROUND: Surveillance for latent tuberculosis in high-risk groups such as healthcare workers is limited by the nonspecificity of the tuberculin skin test (TST) in BCG-vaccinated individuals. The Mycobacterium tuberculosis antigen-specific interferon-gamma release assays (IGRAs) show promise for more accurate latent tuberculosis detection in such groups. OBJECTIVE: To compare the utility of an IGRA, the T-SPOT.TB assay, with that of the TST in healthcare workers with a high rate of BCG vaccination. METHODS: Two hundred seven medical students from 2 consecutive cohorts underwent the T-SPOT.TB test and the TST in their final year of study. Subjects with negative baseline test results underwent repeat testing after working for 1 year as junior physicians in Singapore's public hospitals. RESULTS: The baseline TST result was an induration 10 mm or greater in diameter in 177 of the 205 students who returned to have their TST results evaluated (86.3%), while the baseline T-SPOT.TB assay result was positive in 9 (4.3%) of the students. Repeat T-SPOT.TB testing in 182 baseline-negative subjects showed conversion in 9 (4.9%). A repeat TST in 18 subjects with baseline-negative TST results did not reveal any TST result conversion. CONCLUSIONS: The high rate of positive baseline TST results in our BCG-vaccinated healthcare workers renders the TST unsuitable as a surveillance tool in this tuberculosis risk group. Use of an IGRA has enabled the detection and treatment of latent tuberculosis in this group. Our T-SPOT.TB conversion rate highlights the need for greater tuberculosis awareness and improved infection control practices in our healthcare institutions.","number":"9","journal":"Infection Control & Hospital Epidemiology","author":[{"propositions":[],"lastnames":["Chee"],"firstnames":["C.","B.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Lim"],"firstnames":["L.","K.","Y."],"suffixes":[]},{"propositions":[],"lastnames":["Barkham"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Koh"],"firstnames":["D.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Lam"],"firstnames":["S.","O."],"suffixes":[]},{"propositions":[],"lastnames":["Shen"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Y.","T."],"suffixes":[]}],"year":"2009","keywords":"Adult, BCG Vaccine, Chi Square Test, Data Analysis Software, Demography, Descriptive Statistics, Female, Fisher's Exact Test, Funding Source, Hospitals, Public, Human, Interferon-Gamma Release Tests – Evaluation, Male, Physicians, Questionnaires, Self Report, Singapore, Students, Medical, T-Tests, Time Factors, Tuberculin Test, Tuberculosis – Diagnosis – Singapore","pages":"870–875","bibtex":"@article{chee_use_2009,\n\ttitle = {Use of a {T} cell interferon-gamma release assay to evaluate tuberculosis risk in newly qualified physicians in {Singapore} healthcare institutions},\n\tvolume = {30},\n\tissn = {0899-823X},\n\turl = {http://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105417357&site=ehost-live},\n\tdoi = {10.1086/599284},\n\tabstract = {BACKGROUND: Surveillance for latent tuberculosis in high-risk groups such as healthcare workers is limited by the nonspecificity of the tuberculin skin test (TST) in BCG-vaccinated individuals. The Mycobacterium tuberculosis antigen-specific interferon-gamma release assays (IGRAs) show promise for more accurate latent tuberculosis detection in such groups. OBJECTIVE: To compare the utility of an IGRA, the T-SPOT.TB assay, with that of the TST in healthcare workers with a high rate of BCG vaccination. METHODS: Two hundred seven medical students from 2 consecutive cohorts underwent the T-SPOT.TB test and the TST in their final year of study. Subjects with negative baseline test results underwent repeat testing after working for 1 year as junior physicians in Singapore's public hospitals. RESULTS: The baseline TST result was an induration 10 mm or greater in diameter in 177 of the 205 students who returned to have their TST results evaluated (86.3\\%), while the baseline T-SPOT.TB assay result was positive in 9 (4.3\\%) of the students. Repeat T-SPOT.TB testing in 182 baseline-negative subjects showed conversion in 9 (4.9\\%). A repeat TST in 18 subjects with baseline-negative TST results did not reveal any TST result conversion. CONCLUSIONS: The high rate of positive baseline TST results in our BCG-vaccinated healthcare workers renders the TST unsuitable as a surveillance tool in this tuberculosis risk group. Use of an IGRA has enabled the detection and treatment of latent tuberculosis in this group. Our T-SPOT.TB conversion rate highlights the need for greater tuberculosis awareness and improved infection control practices in our healthcare institutions.},\n\tnumber = {9},\n\tjournal = {Infection Control \\& Hospital Epidemiology},\n\tauthor = {Chee, C. B. E. and Lim, L. K. Y. and Barkham, T. M. and Koh, D. R. and Lam, S. O. and Shen, L. and Wang, Y. T.},\n\tyear = {2009},\n\tkeywords = {Adult, BCG Vaccine, Chi Square Test, Data Analysis Software, Demography, Descriptive Statistics, Female, Fisher's Exact Test, Funding Source, Hospitals, Public, Human, Interferon-Gamma Release Tests -- Evaluation, Male, Physicians, Questionnaires, Self Report, Singapore, Students, Medical, T-Tests, Time Factors, Tuberculin Test, Tuberculosis -- Diagnosis -- Singapore},\n\tpages = {870--875},\n}\n\n","author_short":["Chee, C. B. E.","Lim, L. K. Y.","Barkham, T. M.","Koh, D. R.","Lam, S. O.","Shen, L.","Wang, Y. T."],"key":"chee_use_2009","id":"chee_use_2009","bibbaseid":"chee-lim-barkham-koh-lam-shen-wang-useofatcellinterferongammareleaseassaytoevaluatetuberculosisriskinnewlyqualifiedphysiciansinsingaporehealthcareinstitutions-2009","role":"author","urls":{"Paper":"http://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105417357&site=ehost-live"},"keyword":["Adult","BCG Vaccine","Chi Square Test","Data Analysis Software","Demography","Descriptive Statistics","Female","Fisher's Exact Test","Funding Source","Hospitals","Public","Human","Interferon-Gamma Release Tests – Evaluation","Male","Physicians","Questionnaires","Self Report","Singapore","Students","Medical","T-Tests","Time Factors","Tuberculin Test","Tuberculosis – Diagnosis – Singapore"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/vincentwntu","creationDate":"2020-01-26T03:06:33.997Z","downloads":0,"keywords":["adult","bcg vaccine","chi square test","data analysis software","demography","descriptive statistics","female","fisher's exact test","funding source","hospitals","public","human","interferon-gamma release tests – evaluation","male","physicians","questionnaires","self report","singapore","students","medical","t-tests","time factors","tuberculin test","tuberculosis – diagnosis – singapore"],"search_terms":["use","cell","interferon","gamma","release","assay","evaluate","tuberculosis","risk","newly","qualified","physicians","singapore","healthcare","institutions","chee","lim","barkham","koh","lam","shen","wang"],"title":"Use of a T cell interferon-gamma release assay to evaluate tuberculosis risk in newly qualified physicians in Singapore healthcare institutions","year":2009,"dataSources":["icTw8KRRMMANXJHRd"]}