Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline. Chen, Y., Ismaila, N., Chua, M. L. K., Colevas, A. D., Haddad, R., Huang, S. H., Wee, J. T. S., Whitley, A. C., Yi, J., Yom, S. S., Chan, A. T. C., Hu, C., Lang, J., Le, Q., Lee, A. W. M., Lee, N., Lin, J., Ma, B., Morgan, T. J., Shah, J., Sun, Y., & Ma, J. Journal of Clinical Oncology, 39(7):840-859, 2021. PMID: 33405943
Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline [link]Paper  doi  abstract   bibtex   
PURPOSEThe aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other healthcare providers on definitive-intent chemoradiotherapy for patients with stage II-IVA nasopharyngeal carcinoma (NPC).METHODSThe Chinese Society of Clinical Oncology (CSCO) and ASCO convened an expert panel of radiation oncology, medical oncology, surgery, and advocacy representatives. The literature search included systematic reviews, meta-analyses, and randomized controlled trials published from 1990 through 2020. Outcomes of interest included survival, distant and locoregional disease control, and quality of life. Expert panel members used this evidence and informal consensus to develop evidence-based guideline recommendations.RESULTSThe literature search identified 108 relevant studies to inform the evidence base for this guideline. Five overarching clinical questions were addressed, which included subquestions on radiotherapy (RT), chemotherapy sequence, and concurrent, induction, and adjuvant chemotherapy options.RECOMMENDATIONSEvidence-based recommendations were developed to address aspects of care related to chemotherapy in combination with RT for the definitive-intent treatment of stage II to IVA NPC.Additional information is available at www.asco.org/head-neck-cancer-guidelines.
@article{doi:10.1200/JCO.20.03237,
author = {Chen, Yu-Pei and Ismaila, Nofisat and Chua, Melvin L. K. and Colevas, A. Dimitrios and Haddad, Robert and Huang, Shao Hui and Wee, Joseph T. S. and Whitley, Alexander C. and Yi, Jun-Lin and Yom, Sue S. and Chan, Anthony T. C. and Hu, Chao-Su and Lang, Jin-Yi and Le, Quynh-Thu and Lee, Anne W. M. and Lee, Nancy and Lin, Jin-Ching and Ma, Brigette and Morgan, Thomas J. and Shah, Jatin and Sun, Ying and Ma, Jun},
title = {Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline},
journal = {Journal of Clinical Oncology},
volume = {39},
number = {7},
pages = {840-859},
year = {2021},
doi = {10.1200/JCO.20.03237},
    note ={PMID: 33405943},

URL = { 
        https://doi.org/10.1200/JCO.20.03237
    
},
eprint = { 
        https://doi.org/10.1200/JCO.20.03237
    
}
,
    abstract = { PURPOSEThe aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other healthcare providers on definitive-intent chemoradiotherapy for patients with stage II-IVA nasopharyngeal carcinoma (NPC).METHODSThe Chinese Society of Clinical Oncology (CSCO) and ASCO convened an expert panel of radiation oncology, medical oncology, surgery, and advocacy representatives. The literature search included systematic reviews, meta-analyses, and randomized controlled trials published from 1990 through 2020. Outcomes of interest included survival, distant and locoregional disease control, and quality of life. Expert panel members used this evidence and informal consensus to develop evidence-based guideline recommendations.RESULTSThe literature search identified 108 relevant studies to inform the evidence base for this guideline. Five overarching clinical questions were addressed, which included subquestions on radiotherapy (RT), chemotherapy sequence, and concurrent, induction, and adjuvant chemotherapy options.RECOMMENDATIONSEvidence-based recommendations were developed to address aspects of care related to chemotherapy in combination with RT for the definitive-intent treatment of stage II to IVA NPC.Additional information is available at www.asco.org/head-neck-cancer-guidelines. }
}

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