@ARTICLE{Chen2015-oa,
  title    = "A {GABAergic} projection from the zona incerta to cortex promotes
              cortical neuron development",
  author   = "Chen, Jiadong and Kriegstein, Arnold R",
  abstract = "$\gamma$-Aminobutyric acid (GABA) is the major inhibitory
              transmitter in the mature brain but is excitatory in the
              developing cortex. We found that mouse zona incerta (ZI)
              projection neurons form a GABAergic axon plexus in neonatal
              cortical layer 1, making synapses with neurons in both deep and
              superficial layers. A similar depolarizing GABAergic plexus
              exists in the developing human cortex. Selectively silencing
              mouse ZI GABAergic neurons at birth decreased synaptic activity
              and apical dendritic complexity of cortical neurons. The ZI
              GABAergic projection becomes inhibitory with maturation and can
              block epileptiform activity in the adult brain. These data reveal
              an early-developing GABAergic projection from the ZI to cortical
              layer 1 that is essential for proper development of cortical
              neurons and balances excitation with inhibition in the adult
              cortex.",
  journal  = "Science",
  volume   =  350,
  number   =  6260,
  pages    = "554--558",
  month    =  oct,
  year     =  2015,
  language = "en"
}

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