Risk Factors for Pandemic (H1N1) 2009 Virus Seroconversion among Hospital Staff, Singapore. Chen, M. I. C., Lee, V. J. M., Barr, I., Lin, C., Goh, R., Lee, C., Singh, B., Tan, J., Lim, W. Y., Cook, A. R., Ang, B., Chow, A., Tan, B. H., Loh, J., Shaw, R., Chia, K. S., Lin, R. T. P., & Leo, Y. S. Emerging Infectious Diseases, 16(10):1554–1561, October, 2010.
Risk Factors for Pandemic (H1N1) 2009 Virus Seroconversion among Hospital Staff, Singapore [link]Paper  doi  abstract   bibtex   
We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June-September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June-October 2009, with seroconversion defined as a \textgreater= 4-fold increase in hemagglutination inhibition titers to pandemic (H1N1) 2009. Of 531 participants, 35 showed evidence of seroconversion. Seroconversion rates were highest in nurses (28/290) and lowest in allied health staff (2/116). Significant risk factors on multivariate analysis were being a nurse (adjusted odds ratio [aOR] 4.5, 95% confidence interval [CI] 1.0-19.6) and working in pandemic (H1N1) 2009 isolation wards (aOR 4.5, 95% CI 1.3-15.6). Contact with pandemic (H1N1) 2009-infected colleagues (aOR 2.5, 95% CI 0.9-6.6) and larger household size (aOR 1.2, 95% CI 1.0-1.4) were of borderline significance. Our study suggests that seroconversion was associated with occupational and nonoccupational risk factors.
@article{chen_risk_2010,
	title = {Risk {Factors} for {Pandemic} ({H1N1}) 2009 {Virus} {Seroconversion} among {Hospital} {Staff}, {Singapore}},
	volume = {16},
	issn = {1080-6040},
	url = {://WOS:000282394800006},
	doi = {10.3201/eid1610.100516},
	abstract = {We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June-September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June-October 2009, with seroconversion defined as a {\textgreater}= 4-fold increase in hemagglutination inhibition titers to pandemic (H1N1) 2009. Of 531 participants, 35 showed evidence of seroconversion. Seroconversion rates were highest in nurses (28/290) and lowest in allied health staff (2/116). Significant risk factors on multivariate analysis were being a nurse (adjusted odds ratio [aOR] 4.5, 95\% confidence interval [CI] 1.0-19.6) and working in pandemic (H1N1) 2009 isolation wards (aOR 4.5, 95\% CI 1.3-15.6). Contact with pandemic (H1N1) 2009-infected colleagues (aOR 2.5, 95\% CI 0.9-6.6) and larger household size (aOR 1.2, 95\% CI 1.0-1.4) were of borderline significance. Our study suggests that seroconversion was associated with occupational and nonoccupational risk factors.},
	language = {English},
	number = {10},
	journal = {Emerging Infectious Diseases},
	author = {Chen, M. I. C. and Lee, V. J. M. and Barr, I. and Lin, C. and Goh, R. and Lee, C. and Singh, B. and Tan, J. and Lim, W. Y. and Cook, A. R. and Ang, B. and Chow, A. and Tan, B. H. and Loh, J. and Shaw, R. and Chia, K. S. and Lin, R. T. P. and Leo, Y. S.},
	month = oct,
	year = {2010},
	keywords = {Immunology, Infectious Diseases, efficacy, emergence, health-care workers, households, infections, influenza vaccination, outbreak, personnel, transmission, united-states},
	pages = {1554--1561},
}

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