Bioorthogonal catalytic patch. Chen, Z., Li, H., Bian, Y., Wang, Z., Chen, G., Zhang, X., Miao, Y., Wen, D., Wang, J., Wan, G., Zeng, Y., Abdou, P., Fang, J., Li, S., Sun, C. J., & Gu, Z. Nature Nanotechnology, 16(8):933–941, 2021. Publisher: Springer US![Bioorthogonal catalytic patch [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial chemistry complementary to enzymatic reactions, enabling the selective labelling of biomolecules or in situ synthesis of bioactive agents via non-natural processes. However, the effective deployment of bioorthogonal catalysis in vivo remains challenging, mired by the safety concerns of metal toxicity or complicated procedures to administer catalysts. Here, we describe a bioorthogonal catalytic device comprising a microneedle array patch integrated with Pd nanoparticles deposited on TiO2 nanosheets. This device is robust and removable, and can mediate the local conversion of caged substrates into their active states in high-level living systems. In particular, we show that such a patch can promote the activation of a prodrug at subcutaneous tumour sites, restoring its parent drug’s therapeutic anticancer properties. This in situ applied device potentiates local treatment efficacy and eliminates off-target prodrug activation and dose-dependent side effects in healthy organs or distant tissues.
@article{chen_bioorthogonal_2021,
title = {Bioorthogonal catalytic patch},
volume = {16},
issn = {17483395},
url = {http://dx.doi.org/10.1038/s41565-021-00910-7},
doi = {10.1038/s41565-021-00910-7},
abstract = {Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial chemistry complementary to enzymatic reactions, enabling the selective labelling of biomolecules or in situ synthesis of bioactive agents via non-natural processes. However, the effective deployment of bioorthogonal catalysis in vivo remains challenging, mired by the safety concerns of metal toxicity or complicated procedures to administer catalysts. Here, we describe a bioorthogonal catalytic device comprising a microneedle array patch integrated with Pd nanoparticles deposited on TiO2 nanosheets. This device is robust and removable, and can mediate the local conversion of caged substrates into their active states in high-level living systems. In particular, we show that such a patch can promote the activation of a prodrug at subcutaneous tumour sites, restoring its parent drug’s therapeutic anticancer properties. This in situ applied device potentiates local treatment efficacy and eliminates off-target prodrug activation and dose-dependent side effects in healthy organs or distant tissues.},
number = {8},
journal = {Nature Nanotechnology},
author = {Chen, Zhaowei and Li, Hongjun and Bian, Yijie and Wang, Zejun and Chen, Guojun and Zhang, Xudong and Miao, Yimin and Wen, Di and Wang, Jinqiang and Wan, Gang and Zeng, Yi and Abdou, Peter and Fang, Jun and Li, Song and Sun, Cheng Jun and Gu, Zhen},
year = {2021},
pmid = {33972760},
note = {Publisher: Springer US},
pages = {933--941},
}
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Here, we describe a bioorthogonal catalytic device comprising a microneedle array patch integrated with Pd nanoparticles deposited on TiO2 nanosheets. This device is robust and removable, and can mediate the local conversion of caged substrates into their active states in high-level living systems. In particular, we show that such a patch can promote the activation of a prodrug at subcutaneous tumour sites, restoring its parent drug’s therapeutic anticancer properties. This in situ applied device potentiates local treatment efficacy and eliminates off-target prodrug activation and dose-dependent side effects in healthy organs or distant tissues.","number":"8","journal":"Nature Nanotechnology","author":[{"propositions":[],"lastnames":["Chen"],"firstnames":["Zhaowei"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Hongjun"],"suffixes":[]},{"propositions":[],"lastnames":["Bian"],"firstnames":["Yijie"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Zejun"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Guojun"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Xudong"],"suffixes":[]},{"propositions":[],"lastnames":["Miao"],"firstnames":["Yimin"],"suffixes":[]},{"propositions":[],"lastnames":["Wen"],"firstnames":["Di"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Jinqiang"],"suffixes":[]},{"propositions":[],"lastnames":["Wan"],"firstnames":["Gang"],"suffixes":[]},{"propositions":[],"lastnames":["Zeng"],"firstnames":["Yi"],"suffixes":[]},{"propositions":[],"lastnames":["Abdou"],"firstnames":["Peter"],"suffixes":[]},{"propositions":[],"lastnames":["Fang"],"firstnames":["Jun"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Song"],"suffixes":[]},{"propositions":[],"lastnames":["Sun"],"firstnames":["Cheng","Jun"],"suffixes":[]},{"propositions":[],"lastnames":["Gu"],"firstnames":["Zhen"],"suffixes":[]}],"year":"2021","pmid":"33972760","note":"Publisher: Springer US","pages":"933–941","bibtex":"@article{chen_bioorthogonal_2021,\n\ttitle = {Bioorthogonal catalytic patch},\n\tvolume = {16},\n\tissn = {17483395},\n\turl = {http://dx.doi.org/10.1038/s41565-021-00910-7},\n\tdoi = {10.1038/s41565-021-00910-7},\n\tabstract = {Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial chemistry complementary to enzymatic reactions, enabling the selective labelling of biomolecules or in situ synthesis of bioactive agents via non-natural processes. However, the effective deployment of bioorthogonal catalysis in vivo remains challenging, mired by the safety concerns of metal toxicity or complicated procedures to administer catalysts. Here, we describe a bioorthogonal catalytic device comprising a microneedle array patch integrated with Pd nanoparticles deposited on TiO2 nanosheets. This device is robust and removable, and can mediate the local conversion of caged substrates into their active states in high-level living systems. In particular, we show that such a patch can promote the activation of a prodrug at subcutaneous tumour sites, restoring its parent drug’s therapeutic anticancer properties. 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