@article{chen_chronic_2014,
	title = {Chronic viral hepatitis in {Asian} patients with inflammatory bowel disease},
	volume = {8},
	issn = {1873-9946},
	url = {http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed15&NEWS=N&AN=71388931},
	abstract = {Background: Hepatitis B (HBV) reactivation and fatal flares have been reported with the use of immunomodulators and biologic therapy, while interferon-based hepatitis C (HCV) therapy may potentially exacerbate inflammatory bowel disease (IBD) activity. Screening for HBV has been recommended for IBD patients; prophylactic antiviral therapy should be started before commencing immunosuppressive treatment in HBsAg+ patients while HBV vaccination is recommended in seronegative patients. Although the prevalence of HBV and HCV in Singapore is 4.1\% and 0.37\% respectively, the prevalence of HBV/HCV infection and serological markers in IBD patients is not well characterised. Recent data also suggests a higher prevalence of HBV infection in IBD patients. Our aim is to evaluate the prevalence of HBV/HCV infection and serological markers in Asian patients with IBD in Singapore, a multiracial country in Southeast Asia, consisting mainly of Chinese (CH), Malays (MAL) and Indians (IND). Method(s): Case notes and electronic records of patients with ulcerative colitis (UC) or Crohn's disease (CD) who were treated at our centre from 2002-2013 were retrospectively reviewed. Medical records were extracted for clinical and laboratory data for IBD and HBV/HCV. The diagnoses of HBV and HCV infection were according to international guidelines and definitions. Data was analysed using student's T-test or chi-square test. Result(s): Of 152 IBD patients (96 UC, 56 CD), 25 (16\%) were not screened for HBV/HCV infection and were excluded. Of 127 included patients (77 UC, 50 CD), 78 were males (61\%) and 49 females (39\%) with median age of 48 (range 17-90); 78 (61\%) were CH, 32 (25\%) IND, 14 (11\%) MAL and 3\% were of other Asian ethnicity. This is a fair representation of local demographics. Past/present HBV infection was found in 13.4\% (Anti-HBc+: 10 UC, 7 CD) of which 4.7\% were chronic HBV carriers (HBsAg+: 4 UC, 2 CD; 5 inactive carriers, 1 eAg-ve chronic hepatitis B) and only 1 CD patient (0.79\%) was diagnosed with Type 1 HCV/HIV coinfection. These were not significantly different from the population prevalence of 4.1\% (p = 0.6) and 0.37\% (p = 0.4). Anti- HBc+ patients were older (mean age 58 vs 46, p {\textless} 0.01), age {\textgreater}40 (18\% vs 5\%) and more common among CH (21\% vs 7\% MAL, 0\% IND, p = 0.02). Among Anti-HBc-ve patients, only 43 (39\%) were anti-HBs+ (vaccinated). A significantly greater proportion of female patients (73\% vs 53\%, p = 0.03) and a trend for those age {\textgreater}40 (67\% vs 51\%, p = 0.1) were not vaccinated. Conclusion(s): The prevalence of HBV/HCV infection among Asian IBD patients in Singapore is similar to the general population. Physicians should be reminded regarding HBV screening (16\% not screened) and vaccination (61\% not vaccinated), especially among Chinese/age {\textgreater}40 (HBV infection) and women/age {\textgreater}40 (vaccination).},
	language = {English},
	number = {SUPPL. 1},
	journal = {Journal of Crohn's and Colitis},
	author = {Chen, W. H. and Lim, W. C.},
	year = {2014},
	keywords = {*Asian, *colitis, *human, *inflammatory bowel disease, *patient, *virus hepatitis, Crohn disease, Hepatitis B virus, Indian, Singapore, Southeast Asia, Student t test, antiviral therapy, biological therapy, chi square test, chronic hepatitis, diagnosis, disease activity, ethnicity, evoked response audiometry, female, hepatitis B, hepatitis B core antibody, hepatitis B surface antibody, hepatitis B surface antigen, hepatitis C, immunomodulating agent, immunosuppressive treatment, infection, interferon, laboratory, male, marker, medical record, mixed infection, physician, population, prevalence, screening, therapy, ulcerative colitis, vaccination},
	pages = {S174--S175},
}

{"_id":"atsX8j8dsCjmL8i8q","bibbaseid":"chen-lim-chronicviralhepatitisinasianpatientswithinflammatoryboweldisease-2014","authorIDs":[],"author_short":["Chen, W. H.","Lim, W. C."],"bibdata":{"bibtype":"article","type":"article","title":"Chronic viral hepatitis in Asian patients with inflammatory bowel disease","volume":"8","issn":"1873-9946","url":"http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed15&NEWS=N&AN=71388931","abstract":"Background: Hepatitis B (HBV) reactivation and fatal flares have been reported with the use of immunomodulators and biologic therapy, while interferon-based hepatitis C (HCV) therapy may potentially exacerbate inflammatory bowel disease (IBD) activity. Screening for HBV has been recommended for IBD patients; prophylactic antiviral therapy should be started before commencing immunosuppressive treatment in HBsAg+ patients while HBV vaccination is recommended in seronegative patients. Although the prevalence of HBV and HCV in Singapore is 4.1% and 0.37% respectively, the prevalence of HBV/HCV infection and serological markers in IBD patients is not well characterised. Recent data also suggests a higher prevalence of HBV infection in IBD patients. Our aim is to evaluate the prevalence of HBV/HCV infection and serological markers in Asian patients with IBD in Singapore, a multiracial country in Southeast Asia, consisting mainly of Chinese (CH), Malays (MAL) and Indians (IND). Method(s): Case notes and electronic records of patients with ulcerative colitis (UC) or Crohn's disease (CD) who were treated at our centre from 2002-2013 were retrospectively reviewed. Medical records were extracted for clinical and laboratory data for IBD and HBV/HCV. The diagnoses of HBV and HCV infection were according to international guidelines and definitions. Data was analysed using student's T-test or chi-square test. Result(s): Of 152 IBD patients (96 UC, 56 CD), 25 (16%) were not screened for HBV/HCV infection and were excluded. Of 127 included patients (77 UC, 50 CD), 78 were males (61%) and 49 females (39%) with median age of 48 (range 17-90); 78 (61%) were CH, 32 (25%) IND, 14 (11%) MAL and 3% were of other Asian ethnicity. This is a fair representation of local demographics. Past/present HBV infection was found in 13.4% (Anti-HBc+: 10 UC, 7 CD) of which 4.7% were chronic HBV carriers (HBsAg+: 4 UC, 2 CD; 5 inactive carriers, 1 eAg-ve chronic hepatitis B) and only 1 CD patient (0.79%) was diagnosed with Type 1 HCV/HIV coinfection. These were not significantly different from the population prevalence of 4.1% (p = 0.6) and 0.37% (p = 0.4). Anti- HBc+ patients were older (mean age 58 vs 46, p \\textless 0.01), age \\textgreater40 (18% vs 5%) and more common among CH (21% vs 7% MAL, 0% IND, p = 0.02). Among Anti-HBc-ve patients, only 43 (39%) were anti-HBs+ (vaccinated). A significantly greater proportion of female patients (73% vs 53%, p = 0.03) and a trend for those age \\textgreater40 (67% vs 51%, p = 0.1) were not vaccinated. Conclusion(s): The prevalence of HBV/HCV infection among Asian IBD patients in Singapore is similar to the general population. Physicians should be reminded regarding HBV screening (16% not screened) and vaccination (61% not vaccinated), especially among Chinese/age \\textgreater40 (HBV infection) and women/age \\textgreater40 (vaccination).","language":"English","number":"SUPPL. 1","journal":"Journal of Crohn's and Colitis","author":[{"propositions":[],"lastnames":["Chen"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Lim"],"firstnames":["W.","C."],"suffixes":[]}],"year":"2014","keywords":"*Asian, *colitis, *human, *inflammatory bowel disease, *patient, *virus hepatitis, Crohn disease, Hepatitis B virus, Indian, Singapore, Southeast Asia, Student t test, antiviral therapy, biological therapy, chi square test, chronic hepatitis, diagnosis, disease activity, ethnicity, evoked response audiometry, female, hepatitis B, hepatitis B core antibody, hepatitis B surface antibody, hepatitis B surface antigen, hepatitis C, immunomodulating agent, immunosuppressive treatment, infection, interferon, laboratory, male, marker, medical record, mixed infection, physician, population, prevalence, screening, therapy, ulcerative colitis, vaccination","pages":"S174–S175","bibtex":"@article{chen_chronic_2014,\n\ttitle = {Chronic viral hepatitis in {Asian} patients with inflammatory bowel disease},\n\tvolume = {8},\n\tissn = {1873-9946},\n\turl = {http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed15&NEWS=N&AN=71388931},\n\tabstract = {Background: Hepatitis B (HBV) reactivation and fatal flares have been reported with the use of immunomodulators and biologic therapy, while interferon-based hepatitis C (HCV) therapy may potentially exacerbate inflammatory bowel disease (IBD) activity. Screening for HBV has been recommended for IBD patients; prophylactic antiviral therapy should be started before commencing immunosuppressive treatment in HBsAg+ patients while HBV vaccination is recommended in seronegative patients. Although the prevalence of HBV and HCV in Singapore is 4.1\\% and 0.37\\% respectively, the prevalence of HBV/HCV infection and serological markers in IBD patients is not well characterised. Recent data also suggests a higher prevalence of HBV infection in IBD patients. Our aim is to evaluate the prevalence of HBV/HCV infection and serological markers in Asian patients with IBD in Singapore, a multiracial country in Southeast Asia, consisting mainly of Chinese (CH), Malays (MAL) and Indians (IND). Method(s): Case notes and electronic records of patients with ulcerative colitis (UC) or Crohn's disease (CD) who were treated at our centre from 2002-2013 were retrospectively reviewed. Medical records were extracted for clinical and laboratory data for IBD and HBV/HCV. The diagnoses of HBV and HCV infection were according to international guidelines and definitions. Data was analysed using student's T-test or chi-square test. Result(s): Of 152 IBD patients (96 UC, 56 CD), 25 (16\\%) were not screened for HBV/HCV infection and were excluded. Of 127 included patients (77 UC, 50 CD), 78 were males (61\\%) and 49 females (39\\%) with median age of 48 (range 17-90); 78 (61\\%) were CH, 32 (25\\%) IND, 14 (11\\%) MAL and 3\\% were of other Asian ethnicity. This is a fair representation of local demographics. Past/present HBV infection was found in 13.4\\% (Anti-HBc+: 10 UC, 7 CD) of which 4.7\\% were chronic HBV carriers (HBsAg+: 4 UC, 2 CD; 5 inactive carriers, 1 eAg-ve chronic hepatitis B) and only 1 CD patient (0.79\\%) was diagnosed with Type 1 HCV/HIV coinfection. These were not significantly different from the population prevalence of 4.1\\% (p = 0.6) and 0.37\\% (p = 0.4). Anti- HBc+ patients were older (mean age 58 vs 46, p {\\textless} 0.01), age {\\textgreater}40 (18\\% vs 5\\%) and more common among CH (21\\% vs 7\\% MAL, 0\\% IND, p = 0.02). Among Anti-HBc-ve patients, only 43 (39\\%) were anti-HBs+ (vaccinated). A significantly greater proportion of female patients (73\\% vs 53\\%, p = 0.03) and a trend for those age {\\textgreater}40 (67\\% vs 51\\%, p = 0.1) were not vaccinated. Conclusion(s): The prevalence of HBV/HCV infection among Asian IBD patients in Singapore is similar to the general population. Physicians should be reminded regarding HBV screening (16\\% not screened) and vaccination (61\\% not vaccinated), especially among Chinese/age {\\textgreater}40 (HBV infection) and women/age {\\textgreater}40 (vaccination).},\n\tlanguage = {English},\n\tnumber = {SUPPL. 1},\n\tjournal = {Journal of Crohn's and Colitis},\n\tauthor = {Chen, W. H. and Lim, W. C.},\n\tyear = {2014},\n\tkeywords = {*Asian, *colitis, *human, *inflammatory bowel disease, *patient, *virus hepatitis, Crohn disease, Hepatitis B virus, Indian, Singapore, Southeast Asia, Student t test, antiviral therapy, biological therapy, chi square test, chronic hepatitis, diagnosis, disease activity, ethnicity, evoked response audiometry, female, hepatitis B, hepatitis B core antibody, hepatitis B surface antibody, hepatitis B surface antigen, hepatitis C, immunomodulating agent, immunosuppressive treatment, infection, interferon, laboratory, male, marker, medical record, mixed infection, physician, population, prevalence, screening, therapy, ulcerative colitis, vaccination},\n\tpages = {S174--S175},\n}\n\n","author_short":["Chen, W. H.","Lim, W. C."],"key":"chen_chronic_2014","id":"chen_chronic_2014","bibbaseid":"chen-lim-chronicviralhepatitisinasianpatientswithinflammatoryboweldisease-2014","role":"author","urls":{"Paper":"http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed15&NEWS=N&AN=71388931"},"keyword":["*Asian","*colitis","*human","*inflammatory bowel disease","*patient","*virus hepatitis","Crohn disease","Hepatitis B virus","Indian","Singapore","Southeast Asia","Student t test","antiviral therapy","biological therapy","chi square test","chronic hepatitis","diagnosis","disease activity","ethnicity","evoked response audiometry","female","hepatitis B","hepatitis B core antibody","hepatitis B surface antibody","hepatitis B surface antigen","hepatitis C","immunomodulating agent","immunosuppressive treatment","infection","interferon","laboratory","male","marker","medical record","mixed infection","physician","population","prevalence","screening","therapy","ulcerative colitis","vaccination"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/vincentwntu","creationDate":"2020-01-26T03:06:33.993Z","downloads":0,"keywords":["*asian","*colitis","*human","*inflammatory bowel disease","*patient","*virus hepatitis","crohn disease","hepatitis b virus","indian","singapore","southeast asia","student t test","antiviral therapy","biological therapy","chi square test","chronic hepatitis","diagnosis","disease activity","ethnicity","evoked response audiometry","female","hepatitis b","hepatitis b core antibody","hepatitis b surface antibody","hepatitis b surface antigen","hepatitis c","immunomodulating agent","immunosuppressive treatment","infection","interferon","laboratory","male","marker","medical record","mixed infection","physician","population","prevalence","screening","therapy","ulcerative colitis","vaccination"],"search_terms":["chronic","viral","hepatitis","asian","patients","inflammatory","bowel","disease","chen","lim"],"title":"Chronic viral hepatitis in Asian patients with inflammatory bowel disease","year":2014,"dataSources":["icTw8KRRMMANXJHRd"]}