The trans-ancestral genomic architecture of glycemic traits. Chen, J., Spracklen, C. N, Marenne, G., Varshney, A., Corbin, L. J, Luan, J., Willems, S. M, Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S, Mägi, R., Waage, J., Li-Gao, R., Chan, K. H. K., Yao, J., Anasanti, M. D, Chu, A. Y, Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J., Huo, S., Kaakinen, M. A, Louie, T., März, W., Moreno-Macias, H., Ndungu, A., Nelson, S. C, Nolte, I. M, North, K. E, Raulerson, C. K, Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X., Southam, L., Stewart, I. D, Wang, C. A, Wang, Y., Wu, P., Zhang, W., Ahluwalia, T. S, Appel, E. V R, Bielak, L. F, Brody, J. A, Burtt, N. P, Cabrera, C. P, Cade, B. E, Chai, J. F., Chai, X., Chang, L., Chen, C., Chen, B. H, Chitrala, K. N., Chiu, Y., de Haan, H. G, Delgado, G. E, Demirkan, A., Duan, Q., Engmann, J., Fatumo, S. A, Gayán, J., Giulianini, F., Gong, J. H., Gustafsson, S., Hai, Y., Hartwig, F. P, He, J., Heianza, Y., Huang, T., Huerta-Chagoya, A., Hwang, M. Y., Jensen, R. A, Kawaguchi, T., Kentistou, K. A, Kim, Y. J., Kleber, M. E, Kooner, I. K, Lai, S., Lange, L. A, Langefeld, C. D, Lauzon, M., Li, M., Ligthart, S., Liu, J., Loh, M., Long, J., Lyssenko, V., Mangino, M., Marzi, C., Montasser, M. E, Nag, A., Nakatochi, M., Noce, D., Noordam, R., Pistis, G., Preuss, M., Raffield, L., Rasmussen-Torvik, L. J, Rich, S. S, Robertson, N. R, Rueedi, R., Ryan, K., Sanna, S., Saxena, R., Schraut, K. E, Sennblad, B., Setoh, K., Smith, A. V, Sparsø, T., Strawbridge, R. J, Takeuchi, F., Tan, J., Trompet, S., van den Akker, E., van der Most, P. J, Verweij, N., Vogel, M., Wang, H., Wang, C., Wang, N., Warren, H. R, Wen, W., Wilsgaard, T., Wong, A., Wood, A. R, Xie, T., Zafarmand, M. H., Zhao, J., Zhao, W., Amin, N., Arzumanyan, Z., Astrup, A., Bakker, S. J L, Baldassarre, D., Beekman, M., Bergman, R. N, Bertoni, A., Blüher, M., Bonnycastle, L. L, Bornstein, S. R, Bowden, D. W, Cai, Q., Campbell, A., Campbell, H., Chang, Y. C., de Geus, E. J C, Dehghan, A., Du, S., Eiriksdottir, G., Farmaki, A. E., Frånberg, M., Fuchsberger, C., Gao, Y., Gjesing, A. P, Goel, A., Han, S., Hartman, C. A, Herder, C., Hicks, A. A, Hsieh, C., Hsueh, W. A, Ichihara, S., Igase, M., Ikram, M A., Johnson, W C., Jørgensen, M. E, Joshi, P. K, Kalyani, R. R, Kandeel, F. R, Katsuya, T., Khor, C. C., Kiess, W., Kolcic, I., Kuulasmaa, T., Kuusisto, J., Läll, K., Lam, K., Lawlor, D. A, Lee, N. R, Lemaitre, R. N, Li, H., Lifelines Cohort Study, Lin, S., Lindström, J., Linneberg, A., Liu, J., Lorenzo, C., Matsubara, T., Matsuda, F., Mingrone, G., Mooijaart, S., Moon, S., Nabika, T., Nadkarni, G. N, Nadler, J. L, Nelis, M., Neville, M. J, Norris, J. M, Ohyagi, Y., Peters, A., Peyser, P. A, Polasek, O., Qi, Q., Raven, D., Reilly, D. F, Reiner, A., Rivideneira, F., Roll, K., Rudan, I., Sabanayagam, C., Sandow, K., Sattar, N., Schürmann, A., Shi, J., Stringham, H. M, Taylor, K. D, Teslovich, T. M, Thuesen, B., Timmers, P. R H J, Tremoli, E., Tsai, M. Y, Uitterlinden, A., van Dam, R. M, van Heemst, D., van Hylckama Vlieg, A., van Vliet-Ostaptchouk, J. V, Vangipurapu, J., Vestergaard, H., Wang, T., Willems van Dijk, K., Zemunik, T., Abecasis, G. R, Adair, L. S, Aguilar-Salinas, C. A., Alarcón-Riquelme, M. E, An, P., Aviles-Santa, L., Becker, D. M, Beilin, L. J, Bergmann, S., Bisgaard, H., Black, C., Boehnke, M., Boerwinkle, E., Böhm, B. O, Bønnelykke, K., Boomsma, D I, Bottinger, E. P, Buchanan, T. A, Canouil, M., Caulfield, M. J, Chambers, J. C, Chasman, D. I, Chen, Y. I., Cheng, C., Collins, F. S, Correa, A., Cucca, F., de Silva, H J., Dedoussis, G., Elmståhl, S., Evans, M. K, Ferrannini, E., Ferrucci, L., Florez, J. C, Franks, P. W, Frayling, T. M, Froguel, P., Gigante, B., Goodarzi, M. O, Gordon-Larsen, P., Grallert, H., Grarup, N., Grimsgaard, S., Groop, L., Gudnason, V., Guo, X., Hamsten, A., Hansen, T., Hayward, C., Heckbert, S. R, Horta, B. L, Huang, W., Ingelsson, E., James, P. S, Jarvelin, M., Jonas, J. B, Jukema, J W., Kaleebu, P., Kaplan, R., Kardia, S. L R, Kato, N., Keinanen-Kiukaanniemi, S. M, Kim, B., Kivimaki, M., Koistinen, H. A, Kooner, J. S, Körner, A., Kovacs, P., Kuh, D., Kumari, M., Kutalik, Z., Laakso, M., Lakka, T. A, Launer, L. J, Leander, K., Li, H., Lin, X., Lind, L., Lindgren, C., Liu, S., Loos, R. J F, Magnusson, P. K E, Mahajan, A., Metspalu, A., Mook-Kanamori, D. O, Mori, T. A, Munroe, P. B, Njølstad, I., O'Connell, J. R, Oldehinkel, A. J, Ong, K. K, Padmanabhan, S., Palmer, C. N A, Palmer, N. D, Pedersen, O., Pennell, C. E, Porteous, D. J, Pramstaller, P. P, Province, M. A, Psaty, B. M, Qi, L., Raffel, L. J, Rauramaa, R., Redline, S., Ridker, P. M, Rosendaal, F. R, Saaristo, T. E, Sandhu, M., Saramies, J., Schneiderman, N., Schwarz, P., Scott, L. J, Selvin, E., Sever, P., Shu, X., Slagboom, P E., Small, K. S, Smith, B. H, Snieder, H., Sofer, T., Sørensen, T. I A, Spector, T. D, Stanton, A., Steves, C. J, Stumvoll, M., Sun, L., Tabara, Y., Tai, E S., Timpson, N. J, Tönjes, A., Tuomilehto, J., Tusie, T., Uusitupa, M., van der Harst, P., van Duijn, C., Vitart, V., Vollenweider, P., Vrijkotte, T. G M, Wagenknecht, L. E, Walker, M., Wang, Y. X, Wareham, N. J, Watanabe, R. M, Watkins, H., Wei, W. B, Wickremasinghe, A. R, Willemsen, G., Wilson, J. F, Wong, T., Wu, J., Xiang, A. H, Yanek, L. R, Yengo, L., Yokota, M., Zeggini, E., Zheng, W., Zonderman, A. B, Rotter, J. I, Gloyn, A. L, McCarthy, M. I, Dupuis, J., Meigs, J. B, Scott, R. A, Prokopenko, I., Leong, A., Liu, C., Parker, S. C J, Mohlke, K. L, Langenberg, C., Wheeler, E., Morris, A. P, Barroso, I., Meta-Analysis of Glucose, & (MAGIC), I. T. C. Nat Genet, 53(6):840-860, Jun, 2021.
The trans-ancestral genomic architecture of glycemic traits [link]Paper  doi  abstract   bibtex   
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.
@article{Chen:2021aa,
	abstract = {Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.},
	author = {Chen, Ji and Spracklen, Cassandra N and Marenne, Ga{\"e}lle and Varshney, Arushi and Corbin, Laura J and Luan, Jian'an and Willems, Sara M and Wu, Ying and Zhang, Xiaoshuai and Horikoshi, Momoko and Boutin, Thibaud S and M{\"a}gi, Reedik and Waage, Johannes and Li-Gao, Ruifang and Chan, Kei Hang Katie and Yao, Jie and Anasanti, Mila D and Chu, Audrey Y and Claringbould, Annique and Heikkinen, Jani and Hong, Jaeyoung and Hottenga, Jouke-Jan and Huo, Shaofeng and Kaakinen, Marika A and Louie, Tin and M{\"a}rz, Winfried and Moreno-Macias, Hortensia and Ndungu, Anne and Nelson, Sarah C and Nolte, Ilja M and North, Kari E and Raulerson, Chelsea K and Ray, Debashree and Rohde, Rebecca and Rybin, Denis and Schurmann, Claudia and Sim, Xueling and Southam, Lorraine and Stewart, Isobel D and Wang, Carol A and Wang, Yujie and Wu, Peitao and Zhang, Weihua and Ahluwalia, Tarunveer S and Appel, Emil V R and Bielak, Lawrence F and Brody, Jennifer A and Burtt, No{\"e}l P and Cabrera, Claudia P and Cade, Brian E and Chai, Jin Fang and Chai, Xiaoran and Chang, Li-Ching and Chen, Chien-Hsiun and Chen, Brian H and Chitrala, Kumaraswamy Naidu and Chiu, Yen-Feng and de Haan, Hugoline G and Delgado, Graciela E and Demirkan, Ayse and Duan, Qing and Engmann, Jorgen and Fatumo, Segun A and Gay{\'a}n, Javier and Giulianini, Franco and Gong, Jung Ho and Gustafsson, Stefan and Hai, Yang and Hartwig, Fernando P and He, Jing and Heianza, Yoriko and Huang, Tao and Huerta-Chagoya, Alicia and Hwang, Mi Yeong and Jensen, Richard A and Kawaguchi, Takahisa and Kentistou, Katherine A and Kim, Young Jin and Kleber, Marcus E and Kooner, Ishminder K and Lai, Shuiqing and Lange, Leslie A and Langefeld, Carl D and Lauzon, Marie and Li, Man and Ligthart, Symen and Liu, Jun and Loh, Marie and Long, Jirong and Lyssenko, Valeriya and Mangino, Massimo and Marzi, Carola and Montasser, May E and Nag, Abhishek and Nakatochi, Masahiro and Noce, Damia and Noordam, Raymond and Pistis, Giorgio and Preuss, Michael and Raffield, Laura and Rasmussen-Torvik, Laura J and Rich, Stephen S and Robertson, Neil R and Rueedi, Rico and Ryan, Kathleen and Sanna, Serena and Saxena, Richa and Schraut, Katharina E and Sennblad, Bengt and Setoh, Kazuya and Smith, Albert V and Spars{\o}, Thomas and Strawbridge, Rona J and Takeuchi, Fumihiko and Tan, Jingyi and Trompet, Stella and van den Akker, Erik and van der Most, Peter J and Verweij, Niek and Vogel, Mandy and Wang, Heming and Wang, Chaolong and Wang, Nan and Warren, Helen R and Wen, Wanqing and Wilsgaard, Tom and Wong, Andrew and Wood, Andrew R and Xie, Tian and Zafarmand, Mohammad Hadi and Zhao, Jing-Hua and Zhao, Wei and Amin, Najaf and Arzumanyan, Zorayr and Astrup, Arne and Bakker, Stephan J L and Baldassarre, Damiano and Beekman, Marian and Bergman, Richard N and Bertoni, Alain and Bl{\"u}her, Matthias and Bonnycastle, Lori L and Bornstein, Stefan R and Bowden, Donald W and Cai, Qiuyin and Campbell, Archie and Campbell, Harry and Chang, Yi Cheng and de Geus, Eco J C and Dehghan, Abbas and Du, Shufa and Eiriksdottir, Gudny and Farmaki, Aliki Eleni and Fr{\aa}nberg, Mattias and Fuchsberger, Christian and Gao, Yutang and Gjesing, Anette P and Goel, Anuj and Han, Sohee and Hartman, Catharina A and Herder, Christian and Hicks, Andrew A and Hsieh, Chang-Hsun and Hsueh, Willa A and Ichihara, Sahoko and Igase, Michiya and Ikram, M Arfan and Johnson, W Craig and J{\o}rgensen, Marit E and Joshi, Peter K and Kalyani, Rita R and Kandeel, Fouad R and Katsuya, Tomohiro and Khor, Chiea Chuen and Kiess, Wieland and Kolcic, Ivana and Kuulasmaa, Teemu and Kuusisto, Johanna and L{\"a}ll, Kristi and Lam, Kelvin and Lawlor, Deborah A and Lee, Nanette R and Lemaitre, Rozenn N and Li, Honglan and {Lifelines Cohort Study} and Lin, Shih-Yi and Lindstr{\"o}m, Jaana and Linneberg, Allan and Liu, Jianjun and Lorenzo, Carlos and Matsubara, Tatsuaki and Matsuda, Fumihiko and Mingrone, Geltrude and Mooijaart, Simon and Moon, Sanghoon and Nabika, Toru and Nadkarni, Girish N and Nadler, Jerry L and Nelis, Mari and Neville, Matt J and Norris, Jill M and Ohyagi, Yasumasa and Peters, Annette and Peyser, Patricia A and Polasek, Ozren and Qi, Qibin and Raven, Dennis and Reilly, Dermot F and Reiner, Alex and Rivideneira, Fernando and Roll, Kathryn and Rudan, Igor and Sabanayagam, Charumathi and Sandow, Kevin and Sattar, Naveed and Sch{\"u}rmann, Annette and Shi, Jinxiu and Stringham, Heather M and Taylor, Kent D and Teslovich, Tanya M and Thuesen, Betina and Timmers, Paul R H J and Tremoli, Elena and Tsai, Michael Y and Uitterlinden, Andre and van Dam, Rob M and van Heemst, Diana and van Hylckama Vlieg, Astrid and van Vliet-Ostaptchouk, Jana V and Vangipurapu, Jagadish and Vestergaard, Henrik and Wang, Tao and Willems van Dijk, Ko and Zemunik, Tatijana and Abecasis, Gon{\c c}alo R and Adair, Linda S and Aguilar-Salinas, Carlos Alberto and Alarc{\'o}n-Riquelme, Marta E and An, Ping and Aviles-Santa, Larissa and Becker, Diane M and Beilin, Lawrence J and Bergmann, Sven and Bisgaard, Hans and Black, Corri and Boehnke, Michael and Boerwinkle, Eric and B{\"o}hm, Bernhard O and B{\o}nnelykke, Klaus and Boomsma, D I and Bottinger, Erwin P and Buchanan, Thomas A and Canouil, Micka{\"e}l and Caulfield, Mark J and Chambers, John C and Chasman, Daniel I and Chen, Yii-Der Ida and Cheng, Ching-Yu and Collins, Francis S and Correa, Adolfo and Cucca, Francesco and de Silva, H Janaka and Dedoussis, George and Elmst{\aa}hl, S{\"o}lve and Evans, Michele K and Ferrannini, Ele and Ferrucci, Luigi and Florez, Jose C and Franks, Paul W and Frayling, Timothy M and Froguel, Philippe and Gigante, Bruna and Goodarzi, Mark O and Gordon-Larsen, Penny and Grallert, Harald and Grarup, Niels and Grimsgaard, Sameline and Groop, Leif and Gudnason, Vilmundur and Guo, Xiuqing and Hamsten, Anders and Hansen, Torben and Hayward, Caroline and Heckbert, Susan R and Horta, Bernardo L and Huang, Wei and Ingelsson, Erik and James, Pankow S and Jarvelin, Marjo-Ritta and Jonas, Jost B and Jukema, J Wouter and Kaleebu, Pontiano and Kaplan, Robert and Kardia, Sharon L R and Kato, Norihiro and Keinanen-Kiukaanniemi, Sirkka M and Kim, Bong-Jo and Kivimaki, Mika and Koistinen, Heikki A and Kooner, Jaspal S and K{\"o}rner, Antje and Kovacs, Peter and Kuh, Diana and Kumari, Meena and Kutalik, Zoltan and Laakso, Markku and Lakka, Timo A and Launer, Lenore J and Leander, Karin and Li, Huaixing and Lin, Xu and Lind, Lars and Lindgren, Cecilia and Liu, Simin and Loos, Ruth J F and Magnusson, Patrik K E and Mahajan, Anubha and Metspalu, Andres and Mook-Kanamori, Dennis O and Mori, Trevor A and Munroe, Patricia B and Nj{\o}lstad, Inger and O'Connell, Jeffrey R and Oldehinkel, Albertine J and Ong, Ken K and Padmanabhan, Sandosh and Palmer, Colin N A and Palmer, Nicholette D and Pedersen, Oluf and Pennell, Craig E and Porteous, David J and Pramstaller, Peter P and Province, Michael A and Psaty, Bruce M and Qi, Lu and Raffel, Leslie J and Rauramaa, Rainer and Redline, Susan and Ridker, Paul M and Rosendaal, Frits R and Saaristo, Timo E and Sandhu, Manjinder and Saramies, Jouko and Schneiderman, Neil and Schwarz, Peter and Scott, Laura J and Selvin, Elizabeth and Sever, Peter and Shu, Xiao-Ou and Slagboom, P Eline and Small, Kerrin S and Smith, Blair H and Snieder, Harold and Sofer, Tamar and S{\o}rensen, Thorkild I A and Spector, Tim D and Stanton, Alice and Steves, Claire J and Stumvoll, Michael and Sun, Liang and Tabara, Yasuharu and Tai, E Shyong and Timpson, Nicholas J and T{\"o}njes, Anke and Tuomilehto, Jaakko and Tusie, Teresa and Uusitupa, Matti and van der Harst, Pim and van Duijn, Cornelia and Vitart, Veronique and Vollenweider, Peter and Vrijkotte, Tanja G M and Wagenknecht, Lynne E and Walker, Mark and Wang, Ya X and Wareham, Nick J and Watanabe, Richard M and Watkins, Hugh and Wei, Wen B and Wickremasinghe, Ananda R and Willemsen, Gonneke and Wilson, James F and Wong, Tien-Yin and Wu, Jer-Yuarn and Xiang, Anny H and Yanek, Lisa R and Yengo, Lo{\"\i}c and Yokota, Mitsuhiro and Zeggini, Eleftheria and Zheng, Wei and Zonderman, Alan B and Rotter, Jerome I and Gloyn, Anna L and McCarthy, Mark I and Dupuis, Jos{\'e}e and Meigs, James B and Scott, Robert A and Prokopenko, Inga and Leong, Aaron and Liu, Ching-Ti and Parker, Stephen C J and Mohlke, Karen L and Langenberg, Claudia and Wheeler, Eleanor and Morris, Andrew P and Barroso, In{\^e}s and {Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)}},
	date-added = {2024-05-19 21:00:54 -0400},
	date-modified = {2024-05-19 21:00:54 -0400},
	doi = {10.1038/s41588-021-00852-9},
	journal = {Nat Genet},
	journal-full = {Nature genetics},
	mesh = {Alleles; Blood Glucose; Epigenesis, Genetic; Gene Expression Profiling; Genome, Human; Genome-Wide Association Study; Glycated Hemoglobin; Humans; Multifactorial Inheritance; Physical Chromosome Mapping; Quantitative Trait Loci; Quantitative Trait, Heritable; White People},
	month = {Jun},
	number = {6},
	pages = {840-860},
	pmc = {PMC7610958},
	pmid = {34059833},
	url = {https://pubmed.ncbi.nlm.nih.gov/34059833/},
	pst = {ppublish},
	title = {The trans-ancestral genomic architecture of glycemic traits},
	volume = {53},
	year = {2021},
	bdsk-url-1 = {https://doi.org/10.1038/s41588-021-00852-9}}
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