{"_id":"McYAk22ojNbJDjtnQ","bibbaseid":"cheng-cao-raveh-macarthur-dranchak-chlipala-okoneski-guha-etal-actinoramideastereoisomeridentifiedaspotentantimalarialfromtitrationbasedscreeningofmarinenaturalproductextracts-2015","downloads":0,"creationDate":"2016-02-18T13:03:27.622Z","title":"Actinoramide A stereoisomer identified as potent anti-malarial from titration-based screening of marine natural product extracts","author_short":["Cheng, K. C.","Cao, S.","Raveh, A.","MacArthur, R.","Dranchak, P.","Chlipala, G.","Okoneski, M.","Guha, R.","Eastman, R.","Yuan, J.","Schultz, P.","Su, X.","Tamayo-Castillo, G.","Matainaho, T.","Clardy, J.","Sherman, D.","Inglese, J."],"year":2015,"bibtype":"article","biburl":"https://dl.dropboxusercontent.com/u/26998770/main.bib","bibdata":{"bibtype":"article","type":"article","abstract":"Methods to facilitate the rapid identification and prioritization of active natural product extracts derived from diverse marine microorganisms continues to evolve. Here we describe the discovery of potent anti-malarial activity from two marine Streptomyces sp. extracts identified from thousands tested using a pharmacologically-driven, quantitative high throughput screening approach. Seven compounds were isolated from two phylogenetically related marine Streptomyces species; Streptomyces ballenaensis collected from Costa Rica and Streptomyces bangulaensis collected from Papua New Guinea. Among them, actinoramides A and B belong to an unusually elaborated tetrapeptide series of natural products, including the actinoramides/padanamides. In addition, we characterized of series of new compounds, including actinoramides D, E, epi-actinoramide A and uvitamycins A and B, which are closely related biosynthetic congeners of the previously reported metabolites.","author":[{"propositions":[],"lastnames":["Cheng"],"firstnames":["Ken","Chih-Chien"],"suffixes":[]},{"propositions":[],"lastnames":["Cao"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Raveh"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["MacArthur"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Dranchak"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Chlipala"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["Okoneski"],"firstnames":["M.T."],"suffixes":[]},{"propositions":[],"lastnames":["Guha"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Eastman"],"firstnames":["R.T."],"suffixes":[]},{"propositions":[],"lastnames":["Yuan"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Schultz"],"firstnames":["P.J."],"suffixes":[]},{"propositions":[],"lastnames":["Su"],"firstnames":["Xin-zhuan"],"suffixes":[]},{"propositions":[],"lastnames":["Tamayo-Castillo"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["Matainaho"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Clardy"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Sherman"],"firstnames":["D.H."],"suffixes":[]},{"propositions":[],"lastnames":["Inglese"],"firstnames":["J."],"suffixes":[]}],"date-added":"2015-04-25 16:34:21 +0000","date-modified":"2015-11-27 22:51:20 +0000","journal":"J.~Nat.~Prod.","number":"10","pages":"2411--2422","title":"Actinoramide A stereoisomer identified as potent anti-malarial from titration-based screening of marine natural product extracts","volume":"78","year":"2015","bdsk-url-1":"http://dx.doi.org/10.1021/acs.jnatprod.5b00489","bibtex":"@article{Cheng:2015hb,\n\tAbstract = {Methods to facilitate the rapid identification and prioritization of active natural product extracts derived from diverse marine microorganisms continues to evolve. Here we describe the discovery of potent anti-malarial activity from two marine Streptomyces sp. extracts identified from thousands tested using a pharmacologically-driven, quantitative high throughput screening approach. Seven compounds were isolated from two phylogenetically related marine Streptomyces species; Streptomyces ballenaensis collected from Costa Rica and Streptomyces bangulaensis collected from Papua New Guinea. Among them, actinoramides A and B belong to an unusually elaborated tetrapeptide series of natural products, including the actinoramides/padanamides. In addition, we characterized of series of new compounds, including actinoramides D, E, epi-actinoramide A and uvitamycins A and B, which are closely related biosynthetic congeners of the previously reported metabolites.},\n\tAuthor = {Cheng, Ken Chih-Chien and Cao, S. and Raveh, A. and MacArthur, R. and Dranchak, P. and Chlipala, G. and Okoneski, M.T. and Guha, R. and Eastman, R.T. and Yuan, J. and Schultz, P.J. and Su, Xin-zhuan and Tamayo-Castillo, G. and Matainaho, T. and Clardy, J. and Sherman, D.H. and Inglese, J.},\n\tDate-Added = {2015-04-25 16:34:21 +0000},\n\tDate-Modified = {2015-11-27 22:51:20 +0000},\n\tJournal = {J.~Nat.~Prod.},\n\tNumber = {10},\n\tPages = {2411--2422},\n\tTitle = {Actinoramide A stereoisomer identified as potent anti-malarial from titration-based screening of marine natural product extracts},\n\tVolume = {78},\n\tYear = {2015},\n\tBdsk-Url-1 = {http://dx.doi.org/10.1021/acs.jnatprod.5b00489}}\n\n","author_short":["Cheng, K. C.","Cao, S.","Raveh, A.","MacArthur, R.","Dranchak, P.","Chlipala, G.","Okoneski, M.","Guha, R.","Eastman, R.","Yuan, J.","Schultz, P.","Su, X.","Tamayo-Castillo, G.","Matainaho, T.","Clardy, J.","Sherman, D.","Inglese, J."],"key":"Cheng:2015hb","id":"Cheng:2015hb","bibbaseid":"cheng-cao-raveh-macarthur-dranchak-chlipala-okoneski-guha-etal-actinoramideastereoisomeridentifiedaspotentantimalarialfromtitrationbasedscreeningofmarinenaturalproductextracts-2015","role":"author","urls":{},"downloads":0},"search_terms":["actinoramide","stereoisomer","identified","potent","anti","malarial","titration","based","screening","marine","natural","product","extracts","cheng","cao","raveh","macarthur","dranchak","chlipala","okoneski","guha","eastman","yuan","schultz","su","tamayo-castillo","matainaho","clardy","sherman","inglese"],"keywords":[],"authorIDs":[],"dataSources":["c5japf9eAQRaeMS4h"]}