Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection

Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection. Chetty, A., Darby, M. G., Pillaye, J., Taliep, A., Cunningham, A. F., O'Shea, M. K., Katawa, G., Layland, L. E., Ritter, M., & Horsnell, W. G. Frontiers in Immunology, 14:2082, Frontiers Media S.A., may, 2023.

Paper doi abstract bibtex

Helminth-induced eosinophils accumulate around the parasite at the site of infection, or in parasite-damaged tissues well after the helminth has left the site. The role of helminth-elicited eosinophils in mediating parasite control is complex. While they may contribute to direct parasite-killing and tissue repair, their involvement in long-term immunopathogenesis is a concern. In allergic Siglec-FhiCD101hi, eosinophils are associated with pathology. Research has not shown if equivalent subpopulations of eosinophils are a feature of helminth infection. In this study, we demonstrate that lung migration of rodent hookworm Nippostrongylus brasiliensis (Nb) results in a long-term expansion of distinct Siglec-FhiCD101hi eosinophil subpopulations. Nb-elevated eosinophil populations in the bone marrow and circulation did not present this phenotype. Siglec-FhiCD101hi lung eosinophils exhibited an activated morphology including nuclei hyper-segmentation and cytoplasm degranulation. Recruitment of ST2+ ILC2s and not CD4+ T cells to the lungs was associated with the expansion of Siglec-FhiCD101hi eosinophils. This data identifies a morphologically distinct and persistent subset of Siglec-FhiCD101hi lung eosinophils induced following Nb infection. These eosinophils may contribute to long-term pathology following helminth infection.

@article{Chetty2023,
abstract = {Helminth-induced eosinophils accumulate around the parasite at the site of infection, or in parasite-damaged tissues well after the helminth has left the site. The role of helminth-elicited eosinophils in mediating parasite control is complex. While they may contribute to direct parasite-killing and tissue repair, their involvement in long-term immunopathogenesis is a concern. In allergic Siglec-FhiCD101hi, eosinophils are associated with pathology. Research has not shown if equivalent subpopulations of eosinophils are a feature of helminth infection. In this study, we demonstrate that lung migration of rodent hookworm Nippostrongylus brasiliensis (Nb) results in a long-term expansion of distinct Siglec-FhiCD101hi eosinophil subpopulations. Nb-elevated eosinophil populations in the bone marrow and circulation did not present this phenotype. Siglec-FhiCD101hi lung eosinophils exhibited an activated morphology including nuclei hyper-segmentation and cytoplasm degranulation. Recruitment of ST2+ ILC2s and not CD4+ T cells to the lungs was associated with the expansion of Siglec-FhiCD101hi eosinophils. This data identifies a morphologically distinct and persistent subset of Siglec-FhiCD101hi lung eosinophils induced following Nb infection. These eosinophils may contribute to long-term pathology following helminth infection.},
author = {Chetty, Alisha and Darby, Matthew G. and Pillaye, Jamie and Taliep, A'ishah and Cunningham, Adam F. and O'Shea, Matthew K. and Katawa, Gnatoulma and Layland, Laura E. and Ritter, Manuel and Horsnell, William G.C.},
doi = {10.3389/FIMMU.2023.1170807/BIBTEX},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Chetty et al. - 2023 - Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis in.pdf:pdf},
issn = {16643224},
journal = {Frontiers in Immunology},
keywords = {CD101,ILC2s,Nippostrongylus brasilienis,OA,OA{\_}PMC,Siglec-F,eosinophils,fund{\_}ack,helminths,lung,original},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}ack,original},
month = {may},
pages = {2082},
pmid = {37251384},
publisher = {Frontiers Media S.A.},
title = {{Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm \textit{Nippostrongylus brasiliensis} infection}},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170807/full},
volume = {14},
year = {2023}
}

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