@article{chevalier_evolution_2018,
	title = {Evolution, kidney development, and chronic kidney disease},
	issn = {10849521},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S1084952117304305},
	doi = {10.1016/j.semcdb.2018.05.024},
	abstract = {There is a global epidemic of chronic kidney disease (CKD) characterized by a progressive loss of nephrons, ascribed in large part to a rising incidence of hypertension, metabolic syndrome, and type 2 diabetes mellitus. There is a ten-fold variation in nephron number at birth in the general population, and a 50\% overall decrease in nephron number in the last decades of life. The vicious cycle of nephron loss stimulating hypertrophy by remaining nephrons and resulting in glomerulosclerosis has been regarded as maladaptive, and only partially responsive to angiotensin inhibition. Advances over the past century in kidney physiology, genetics, and development have elucidated many aspects of nephron formation, structure and function. Parallel advances have been achieved in evolutionary biology, with the emergence of evolutionary medicine, a discipline that promises to provide new insight into the treatment of chronic disease.},
	language = {en},
	urldate = {2018-07-06TZ},
	journal = {Seminars in Cell \& Developmental Biology},
	author = {Chevalier, Robert L.},
	month = jun,
	year = {2018}
}

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