Short Communication: Increase of HIV-1 K103N Transmitted Drug Resistance and Its Association with Efavirenz Use in South Korea. Chin, B. S., Shin, H., Kim, G., Wagner, G. A., Gianella, S., & Smith, D. M. AIDS research and human retroviruses, 31(6):603–607, June, 2015. doi abstract bibtex Previous studies reported a relatively low prevalence of transmitted drug resistance (TDR) in South Korea (\textless5%). A genotypic resistance test was performed on 131 treatment-naive HIV-1-infected individuals from February 2013 to February 2014. Eleven individuals (8.4%) presented TDR, of whom eight had K103N, revealing a significant increase in K103N TDR compared to previous studies (p\textless0.001). Using phylogenetic analysis, we identified three distinct clustering pairs with genetic relativeness and a total of five independent strains among the eight K103N cases. Our findings suggest that multiple sources of K103N occurred, most likely as a consequence of increased efavirenz use in South Korea.
@article{chin_short_2015,
title = {Short {Communication}: {Increase} of {HIV}-1 {K103N} {Transmitted} {Drug} {Resistance} and {Its} {Association} with {Efavirenz} {Use} in {South} {Korea}},
volume = {31},
issn = {1931-8405},
shorttitle = {Short {Communication}},
doi = {10.1089/AID.2014.0368},
abstract = {Previous studies reported a relatively low prevalence of transmitted drug resistance (TDR) in South Korea ({\textless}5\%). A genotypic resistance test was performed on 131 treatment-naive HIV-1-infected individuals from February 2013 to February 2014. Eleven individuals (8.4\%) presented TDR, of whom eight had K103N, revealing a significant increase in K103N TDR compared to previous studies (p{\textless}0.001). Using phylogenetic analysis, we identified three distinct clustering pairs with genetic relativeness and a total of five independent strains among the eight K103N cases. Our findings suggest that multiple sources of K103N occurred, most likely as a consequence of increased efavirenz use in South Korea.},
language = {eng},
number = {6},
journal = {AIDS research and human retroviruses},
author = {Chin, Bum Sik and Shin, Hyoung-Shik and Kim, Gayeon and Wagner, Gabriel A. and Gianella, Sara and Smith, Davey M.},
month = jun,
year = {2015},
pmid = {25826122},
pmcid = {PMC4516954},
keywords = {Adult, Anti-HIV Agents, Benzoxazines, Cluster Analysis, Drug Resistance, Viral, Genotype, HIV Infections, HIV Reverse Transcriptase, HIV-1, Humans, Incidence, Male, Molecular Sequence Data, Mutation, Missense, Phylogeny, Republic of Korea, Sequence Analysis, DNA},
pages = {603--607},
}
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