Epidemiology, pathophysiology and contemporary management of cardiogenic shock – a position statement from the Heart Failure Association of the European Society of Cardiology. Chioncel, O., Parissis, J., Mebazaa, A., Thiele, H., Desch, S., Bauersachs, J., Harjola, V., Antohi, E., Arrigo, M., Ben Gal, T., Celutkiene, J., Collins, S. P., DeBacker, D., Iliescu, V. A., Jankowska, E., Jaarsma, T., Keramida, K., Lainscak, M., Lund, L. H, Lyon, A. R., Masip, J., Metra, M., Miro, O., Mortara, A., Mueller, C., Mullens, W., Nikolaou, M., Piepoli, M., Price, S., Rosano, G., Vieillard-Baron, A., Weinstein, J. M., Anker, S. D., Filippatos, G., Ruschitzka, F., Coats, A. J., & Seferovic, P. European Journal of Heart Failure, 22(8):1315–1341, John Wiley & Sons, Ltd, August, 2020.
Epidemiology, pathophysiology and contemporary management of cardiogenic shock – a position statement from the Heart Failure Association of the European Society of Cardiology [link]Paper  doi  abstract   bibtex   
Abstract Cardiogenic shock (CS) is a complex multifactorial clinical syndrome with extremely high mortality, developing as a continuum, and progressing from the initial insult (underlying cause) to the subsequent occurrence of organ failure and death. There is a large spectrum of CS presentations resulting from the interaction between an acute cardiac insult and a patient's underlying cardiac and overall medical condition. Phenotyping patients with CS may have clinical impact on management because classification would support initiation of appropriate therapies. CS management should consider appropriate organization of the health care services, and therapies must be given to the appropriately selected patients, in a timely manner, whilst avoiding iatrogenic harm. Although several consensus-driven algorithms have been proposed, CS management remains challenging and substantial investments in research and development have not yielded proof of efficacy and safety for most of the therapies tested, and outcome in this condition remains poor. Future studies should consider the identification of the new pathophysiological targets, and high-quality translational research should facilitate incorporation of more targeted interventions in clinical research protocols, aimed to improve individual patient outcomes. Designing outcome clinical trials in CS remains particularly challenging in this critical and very costly scenario in cardiology, but information from these trials is imperiously needed to better inform the guidelines and clinical practice. The goal of this review is to summarize the current knowledge concerning the definition, epidemiology, underlying causes, pathophysiology and management of CS based on important lessons from clinical trials and registries, with a focus on improving in-hospital management.
@article{chioncel_epidemiology_2020,
	title = {Epidemiology, pathophysiology and contemporary management of cardiogenic shock – a position statement from the {Heart} {Failure} {Association} of the {European} {Society} of {Cardiology}},
	volume = {22},
	issn = {1388-9842},
	url = {https://doi.org/10.1002/ejhf.1922},
	doi = {10.1002/ejhf.1922},
	abstract = {Abstract Cardiogenic shock (CS) is a complex multifactorial clinical syndrome with extremely high mortality, developing as a continuum, and progressing from the initial insult (underlying cause) to the subsequent occurrence of organ failure and death. There is a large spectrum of CS presentations resulting from the interaction between an acute cardiac insult and a patient's underlying cardiac and overall medical condition. Phenotyping patients with CS may have clinical impact on management because classification would support initiation of appropriate therapies. CS management should consider appropriate organization of the health care services, and therapies must be given to the appropriately selected patients, in a timely manner, whilst avoiding iatrogenic harm. Although several consensus-driven algorithms have been proposed, CS management remains challenging and substantial investments in research and development have not yielded proof of efficacy and safety for most of the therapies tested, and outcome in this condition remains poor. Future studies should consider the identification of the new pathophysiological targets, and high-quality translational research should facilitate incorporation of more targeted interventions in clinical research protocols, aimed to improve individual patient outcomes. Designing outcome clinical trials in CS remains particularly challenging in this critical and very costly scenario in cardiology, but information from these trials is imperiously needed to better inform the guidelines and clinical practice. The goal of this review is to summarize the current knowledge concerning the definition, epidemiology, underlying causes, pathophysiology and management of CS based on important lessons from clinical trials and registries, with a focus on improving in-hospital management.},
	number = {8},
	urldate = {2024-10-16},
	journal = {European Journal of Heart Failure},
	publisher = {John Wiley \& Sons, Ltd},
	author = {Chioncel, Ovidiu and Parissis, John and Mebazaa, Alexandre and Thiele, Holger and Desch, Steffen and Bauersachs, Johann and Harjola, Veli-Pekka and Antohi, Elena-Laura and Arrigo, Mattia and Ben Gal, Tuvia and Celutkiene, Jelena and Collins, Sean P. and DeBacker, Daniel and Iliescu, Vlad A. and Jankowska, Ewa and Jaarsma, Tiny and Keramida, Kalliopi and Lainscak, Mitja and Lund, Lars H and Lyon, Alexander R. and Masip, Josep and Metra, Marco and Miro, Oscar and Mortara, Andrea and Mueller, Christian and Mullens, Wilfried and Nikolaou, Maria and Piepoli, Massimo and Price, Susana and Rosano, Giuseppe and Vieillard-Baron, Antoine and Weinstein, Jean M. and Anker, Stefan D. and Filippatos, Gerasimos and Ruschitzka, Frank and Coats, Andrew J.S. and Seferovic, Petar},
	month = aug,
	year = {2020},
	keywords = {Cardiogenic shock, Cardiology, Consensus, Heart Failure, Humans, Mechanical circulatory support, Multidisciplinary team, Organ dysfunction, Registries, Shock, Cardiogenic, notion},
	pages = {1315--1341},
}
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