Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization

Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization. Chiriaco, M. S., Bianco, M., Nigro, A., Primiceri, E., Ferrara, F., Romano, A., Quattrini, A., Furlan, R., Arima, V., & Maruccio, G. SENSORS, OCT, 2018.
doi abstract bibtex

Interest in extracellular vesicles and in particular microvesicles and exosomes, which are constitutively produced by cells, is on the rise for their huge potential as biomarkers in a high number of disorders and pathologies as they are considered as carriers of information among cells, as well as being responsible for the spreading of diseases. Current methods of analysis of microvesicles and exosomes do not fulfill the requirements for their in-depth investigation and the complete exploitation of their diagnostic and prognostic value. Lab-on-chip methods have the potential and capabilities to bridge this gap and the technology is mature enough to provide all the necessary steps for a completely automated analysis of extracellular vesicles in body fluids. In this paper we provide an overview of the biological role of extracellular vesicles, standard biochemical methods of analysis and their limits, and a survey of lab-on-chip methods that are able to meet the needs of a deeper exploitation of these biological entities to drive their use in common clinical practice.

@article{ ISI:000448661500003,
Author = {Chiriaco, Maria Serena and Bianco, Monica and Nigro, Annamaria and
   Primiceri, Elisabetta and Ferrara, Francesco and Romano, Alessandro and
   Quattrini, Angelo and Furlan, Roberto and Arima, Valentina and Maruccio,
   Giuseppe},
Title = {{Lab-on-Chip for Exosomes and Microvesicles Detection and
   Characterization}},
Journal = {{SENSORS}},
Year = {{2018}},
Volume = {{18}},
Number = {{10}},
Month = {{OCT}},
Abstract = {{Interest in extracellular vesicles and in particular microvesicles and
   exosomes, which are constitutively produced by cells, is on the rise for
   their huge potential as biomarkers in a high number of disorders and
   pathologies as they are considered as carriers of information among
   cells, as well as being responsible for the spreading of diseases.
   Current methods of analysis of microvesicles and exosomes do not fulfill
   the requirements for their in-depth investigation and the complete
   exploitation of their diagnostic and prognostic value. Lab-on-chip
   methods have the potential and capabilities to bridge this gap and the
   technology is mature enough to provide all the necessary steps for a
   completely automated analysis of extracellular vesicles in body fluids.
   In this paper we provide an overview of the biological role of
   extracellular vesicles, standard biochemical methods of analysis and
   their limits, and a survey of lab-on-chip methods that are able to meet
   the needs of a deeper exploitation of these biological entities to drive
   their use in common clinical practice.}},
DOI = {{10.3390/s18103175}},
Article-Number = {{3175}},
ISSN = {{1424-8220}},
ResearcherID-Numbers = {{primiceri, elisabetta/P-8842-2015
   Maruccio, Giuseppe/A-1486-2009
   Chiriaco, Maria Serena/K-6082-2016
   Quattrini, Angelo/J-8373-2018
   Furlan, Roberto/J-9177-2016
   ARIMA, VALENTINA/O-2552-2015}},
ORCID-Numbers = {{Ferrara, Francesco/0000-0002-7290-9542
   primiceri, elisabetta/0000-0002-4196-3538
   Maruccio, Giuseppe/0000-0001-7669-0253
   Chiriaco, Maria Serena/0000-0002-7195-267X
   BIANCO, MONICA/0000-0002-1791-7232
   Quattrini, Angelo/0000-0002-8226-8320
   Furlan, Roberto/0000-0001-7376-9425
   ARIMA, VALENTINA/0000-0002-3429-8365}},
Unique-ID = {{ISI:000448661500003}},
}

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