Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization. Chiriaco, M. S., Bianco, M., Nigro, A., Primiceri, E., Ferrara, F., Romano, A., Quattrini, A., Furlan, R., Arima, V., & Maruccio, G. SENSORS, OCT, 2018. doi abstract bibtex Interest in extracellular vesicles and in particular microvesicles and exosomes, which are constitutively produced by cells, is on the rise for their huge potential as biomarkers in a high number of disorders and pathologies as they are considered as carriers of information among cells, as well as being responsible for the spreading of diseases. Current methods of analysis of microvesicles and exosomes do not fulfill the requirements for their in-depth investigation and the complete exploitation of their diagnostic and prognostic value. Lab-on-chip methods have the potential and capabilities to bridge this gap and the technology is mature enough to provide all the necessary steps for a completely automated analysis of extracellular vesicles in body fluids. In this paper we provide an overview of the biological role of extracellular vesicles, standard biochemical methods of analysis and their limits, and a survey of lab-on-chip methods that are able to meet the needs of a deeper exploitation of these biological entities to drive their use in common clinical practice.
@article{ ISI:000448661500003,
Author = {Chiriaco, Maria Serena and Bianco, Monica and Nigro, Annamaria and
Primiceri, Elisabetta and Ferrara, Francesco and Romano, Alessandro and
Quattrini, Angelo and Furlan, Roberto and Arima, Valentina and Maruccio,
Giuseppe},
Title = {{Lab-on-Chip for Exosomes and Microvesicles Detection and
Characterization}},
Journal = {{SENSORS}},
Year = {{2018}},
Volume = {{18}},
Number = {{10}},
Month = {{OCT}},
Abstract = {{Interest in extracellular vesicles and in particular microvesicles and
exosomes, which are constitutively produced by cells, is on the rise for
their huge potential as biomarkers in a high number of disorders and
pathologies as they are considered as carriers of information among
cells, as well as being responsible for the spreading of diseases.
Current methods of analysis of microvesicles and exosomes do not fulfill
the requirements for their in-depth investigation and the complete
exploitation of their diagnostic and prognostic value. Lab-on-chip
methods have the potential and capabilities to bridge this gap and the
technology is mature enough to provide all the necessary steps for a
completely automated analysis of extracellular vesicles in body fluids.
In this paper we provide an overview of the biological role of
extracellular vesicles, standard biochemical methods of analysis and
their limits, and a survey of lab-on-chip methods that are able to meet
the needs of a deeper exploitation of these biological entities to drive
their use in common clinical practice.}},
DOI = {{10.3390/s18103175}},
Article-Number = {{3175}},
ISSN = {{1424-8220}},
ResearcherID-Numbers = {{primiceri, elisabetta/P-8842-2015
Maruccio, Giuseppe/A-1486-2009
Chiriaco, Maria Serena/K-6082-2016
Quattrini, Angelo/J-8373-2018
Furlan, Roberto/J-9177-2016
ARIMA, VALENTINA/O-2552-2015}},
ORCID-Numbers = {{Ferrara, Francesco/0000-0002-7290-9542
primiceri, elisabetta/0000-0002-4196-3538
Maruccio, Giuseppe/0000-0001-7669-0253
Chiriaco, Maria Serena/0000-0002-7195-267X
BIANCO, MONICA/0000-0002-1791-7232
Quattrini, Angelo/0000-0002-8226-8320
Furlan, Roberto/0000-0001-7376-9425
ARIMA, VALENTINA/0000-0002-3429-8365}},
Unique-ID = {{ISI:000448661500003}},
}
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S.","Bianco, M.","Nigro, A.","Primiceri, E.","Ferrara, F.","Romano, A.","Quattrini, A.","Furlan, R.","Arima, V.","Maruccio, G."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Chiriaco"],"firstnames":["Maria","Serena"],"suffixes":[]},{"propositions":[],"lastnames":["Bianco"],"firstnames":["Monica"],"suffixes":[]},{"propositions":[],"lastnames":["Nigro"],"firstnames":["Annamaria"],"suffixes":[]},{"propositions":[],"lastnames":["Primiceri"],"firstnames":["Elisabetta"],"suffixes":[]},{"propositions":[],"lastnames":["Ferrara"],"firstnames":["Francesco"],"suffixes":[]},{"propositions":[],"lastnames":["Romano"],"firstnames":["Alessandro"],"suffixes":[]},{"propositions":[],"lastnames":["Quattrini"],"firstnames":["Angelo"],"suffixes":[]},{"propositions":[],"lastnames":["Furlan"],"firstnames":["Roberto"],"suffixes":[]},{"propositions":[],"lastnames":["Arima"],"firstnames":["Valentina"],"suffixes":[]},{"propositions":[],"lastnames":["Maruccio"],"firstnames":["Giuseppe"],"suffixes":[]}],"title":"Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization","journal":"SENSORS","year":"2018","volume":"18","number":"10","month":"OCT","abstract":"Interest in extracellular vesicles and in particular microvesicles and exosomes, which are constitutively produced by cells, is on the rise for their huge potential as biomarkers in a high number of disorders and pathologies as they are considered as carriers of information among cells, as well as being responsible for the spreading of diseases. Current methods of analysis of microvesicles and exosomes do not fulfill the requirements for their in-depth investigation and the complete exploitation of their diagnostic and prognostic value. Lab-on-chip methods have the potential and capabilities to bridge this gap and the technology is mature enough to provide all the necessary steps for a completely automated analysis of extracellular vesicles in body fluids. 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Lab-on-chip\n methods have the potential and capabilities to bridge this gap and the\n technology is mature enough to provide all the necessary steps for a\n completely automated analysis of extracellular vesicles in body fluids.\n In this paper we provide an overview of the biological role of\n extracellular vesicles, standard biochemical methods of analysis and\n their limits, and a survey of lab-on-chip methods that are able to meet\n the needs of a deeper exploitation of these biological entities to drive\n their use in common clinical practice.}},\nDOI = {{10.3390/s18103175}},\nArticle-Number = {{3175}},\nISSN = {{1424-8220}},\nResearcherID-Numbers = {{primiceri, elisabetta/P-8842-2015\n Maruccio, Giuseppe/A-1486-2009\n Chiriaco, Maria Serena/K-6082-2016\n Quattrini, Angelo/J-8373-2018\n Furlan, Roberto/J-9177-2016\n ARIMA, VALENTINA/O-2552-2015}},\nORCID-Numbers = {{Ferrara, Francesco/0000-0002-7290-9542\n primiceri, elisabetta/0000-0002-4196-3538\n Maruccio, Giuseppe/0000-0001-7669-0253\n Chiriaco, Maria Serena/0000-0002-7195-267X\n BIANCO, MONICA/0000-0002-1791-7232\n Quattrini, Angelo/0000-0002-8226-8320\n Furlan, Roberto/0000-0001-7376-9425\n ARIMA, VALENTINA/0000-0002-3429-8365}},\nUnique-ID = {{ISI:000448661500003}},\n}\n\n","author_short":["Chiriaco, M. 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