Mapping the Cerebellar Cognitive Affective Syndrome in Patients with Chronic Cerebellar Strokes. Chirino-Pérez, A., Marrufo-Meléndez, O. R., Muñoz-López, J. I., Hernandez-Castillo, C. R., Ramirez-Garcia, G., Díaz, R., Nuñez-Orozco, L., & Fernandez-Ruiz, J. Cerebellum (London, England), June, 2021. doi abstract bibtex The cerebellar cognitive affective syndrome (CCAS) has been consistently described in patients with acute/subacute cerebellar injuries. However, studies with chronic patients have had controversial findings that have not been explored with new cerebellar-target tests, such as the CCAS scale (CCAS-S). The objective of this research is to prove and contrast the usefulness of the CCAS-S and the Montreal Cognitive Assessment (MoCA) test to evaluate cognitive/affective impairments in patients with chronic acquired cerebellar lesions, and to map the cerebellar areas whose lesions correlated with dysfunctions in these tests. CCAS-S and MoCA were administrated to 22 patients with isolated chronic cerebellar strokes and a matched comparison group. The neural bases underpinning both tests were explored with multivariate lesion-symptom mapping (LSM) methods. MoCA and CCAS-S had an adequate test performance with efficient discrimination between patients and healthy volunteers. However, only impairments determined by the CCAS-S resulted in significant regional localization within the cerebellum. Specifically, patients with chronic cerebellar lesions in right-lateralized posterolateral regions manifested cognitive impairments inherent to CCAS. These findings concurred with the anterior-sensorimotor/posterior-cognitive dichotomy in the human cerebellum and revealed clinically intra- and cross-lobular significant regions (portions of right lobule VI, VII, Crus I-II) for verbal tasks that overlap with the "language" functional boundaries in the cerebellum. Our findings prove the usefulness of MoCA and CCAS-S to reveal cognitive impairments in patients with chronic acquired cerebellar lesions. This study extends the understanding of long-term CCAS and introduces multivariate LSM methods to identify clinically intra- and cross-lobular significant regions underpinning chronic CCAS.
@article{chirino-perez_mapping_2021,
title = {Mapping the {Cerebellar} {Cognitive} {Affective} {Syndrome} in {Patients} with {Chronic} {Cerebellar} {Strokes}},
issn = {1473-4230},
doi = {10.1007/s12311-021-01290-3},
abstract = {The cerebellar cognitive affective syndrome (CCAS) has been consistently described in patients with acute/subacute cerebellar injuries. However, studies with chronic patients have had controversial findings that have not been explored with new cerebellar-target tests, such as the CCAS scale (CCAS-S). The objective of this research is to prove and contrast the usefulness of the CCAS-S and the Montreal Cognitive Assessment (MoCA) test to evaluate cognitive/affective impairments in patients with chronic acquired cerebellar lesions, and to map the cerebellar areas whose lesions correlated with dysfunctions in these tests. CCAS-S and MoCA were administrated to 22 patients with isolated chronic cerebellar strokes and a matched comparison group. The neural bases underpinning both tests were explored with multivariate lesion-symptom mapping (LSM) methods. MoCA and CCAS-S had an adequate test performance with efficient discrimination between patients and healthy volunteers. However, only impairments determined by the CCAS-S resulted in significant regional localization within the cerebellum. Specifically, patients with chronic cerebellar lesions in right-lateralized posterolateral regions manifested cognitive impairments inherent to CCAS. These findings concurred with the anterior-sensorimotor/posterior-cognitive dichotomy in the human cerebellum and revealed clinically intra- and cross-lobular significant regions (portions of right lobule VI, VII, Crus I-II) for verbal tasks that overlap with the "language" functional boundaries in the cerebellum. Our findings prove the usefulness of MoCA and CCAS-S to reveal cognitive impairments in patients with chronic acquired cerebellar lesions. This study extends the understanding of long-term CCAS and introduces multivariate LSM methods to identify clinically intra- and cross-lobular significant regions underpinning chronic CCAS.},
language = {eng},
journal = {Cerebellum (London, England)},
author = {Chirino-Pérez, Amanda and Marrufo-Meléndez, Oscar René and Muñoz-López, José Ignacio and Hernandez-Castillo, Carlos R. and Ramirez-Garcia, Gabriel and Díaz, Rosalinda and Nuñez-Orozco, Lilia and Fernandez-Ruiz, Juan},
month = jun,
year = {2021},
pmid = {34109552},
keywords = {Cerebellar cognitive affective syndrome, Cerebellar cognitive affective syndrome scale, Cerebellar stroke, Lesion-symptom mapping, Magnetic resonance imaging},
}
Downloads: 0
{"_id":"seD5qjySCukR2DcnF","bibbaseid":"chirinoprez-marrufomelndez-muozlpez-hernandezcastillo-ramirezgarcia-daz-nuezorozco-fernandezruiz-mappingthecerebellarcognitiveaffectivesyndromeinpatientswithchroniccerebellarstrokes-2021","author_short":["Chirino-Pérez, A.","Marrufo-Meléndez, O. R.","Muñoz-López, J. I.","Hernandez-Castillo, C. R.","Ramirez-Garcia, G.","Díaz, R.","Nuñez-Orozco, L.","Fernandez-Ruiz, J."],"bibdata":{"bibtype":"article","type":"article","title":"Mapping the Cerebellar Cognitive Affective Syndrome in Patients with Chronic Cerebellar Strokes","issn":"1473-4230","doi":"10.1007/s12311-021-01290-3","abstract":"The cerebellar cognitive affective syndrome (CCAS) has been consistently described in patients with acute/subacute cerebellar injuries. However, studies with chronic patients have had controversial findings that have not been explored with new cerebellar-target tests, such as the CCAS scale (CCAS-S). The objective of this research is to prove and contrast the usefulness of the CCAS-S and the Montreal Cognitive Assessment (MoCA) test to evaluate cognitive/affective impairments in patients with chronic acquired cerebellar lesions, and to map the cerebellar areas whose lesions correlated with dysfunctions in these tests. CCAS-S and MoCA were administrated to 22 patients with isolated chronic cerebellar strokes and a matched comparison group. The neural bases underpinning both tests were explored with multivariate lesion-symptom mapping (LSM) methods. MoCA and CCAS-S had an adequate test performance with efficient discrimination between patients and healthy volunteers. However, only impairments determined by the CCAS-S resulted in significant regional localization within the cerebellum. Specifically, patients with chronic cerebellar lesions in right-lateralized posterolateral regions manifested cognitive impairments inherent to CCAS. These findings concurred with the anterior-sensorimotor/posterior-cognitive dichotomy in the human cerebellum and revealed clinically intra- and cross-lobular significant regions (portions of right lobule VI, VII, Crus I-II) for verbal tasks that overlap with the \"language\" functional boundaries in the cerebellum. Our findings prove the usefulness of MoCA and CCAS-S to reveal cognitive impairments in patients with chronic acquired cerebellar lesions. This study extends the understanding of long-term CCAS and introduces multivariate LSM methods to identify clinically intra- and cross-lobular significant regions underpinning chronic CCAS.","language":"eng","journal":"Cerebellum (London, England)","author":[{"propositions":[],"lastnames":["Chirino-Pérez"],"firstnames":["Amanda"],"suffixes":[]},{"propositions":[],"lastnames":["Marrufo-Meléndez"],"firstnames":["Oscar","René"],"suffixes":[]},{"propositions":[],"lastnames":["Muñoz-López"],"firstnames":["José","Ignacio"],"suffixes":[]},{"propositions":[],"lastnames":["Hernandez-Castillo"],"firstnames":["Carlos","R."],"suffixes":[]},{"propositions":[],"lastnames":["Ramirez-Garcia"],"firstnames":["Gabriel"],"suffixes":[]},{"propositions":[],"lastnames":["Díaz"],"firstnames":["Rosalinda"],"suffixes":[]},{"propositions":[],"lastnames":["Nuñez-Orozco"],"firstnames":["Lilia"],"suffixes":[]},{"propositions":[],"lastnames":["Fernandez-Ruiz"],"firstnames":["Juan"],"suffixes":[]}],"month":"June","year":"2021","pmid":"34109552","keywords":"Cerebellar cognitive affective syndrome, Cerebellar cognitive affective syndrome scale, Cerebellar stroke, Lesion-symptom mapping, Magnetic resonance imaging","bibtex":"@article{chirino-perez_mapping_2021,\n\ttitle = {Mapping the {Cerebellar} {Cognitive} {Affective} {Syndrome} in {Patients} with {Chronic} {Cerebellar} {Strokes}},\n\tissn = {1473-4230},\n\tdoi = {10.1007/s12311-021-01290-3},\n\tabstract = {The cerebellar cognitive affective syndrome (CCAS) has been consistently described in patients with acute/subacute cerebellar injuries. However, studies with chronic patients have had controversial findings that have not been explored with new cerebellar-target tests, such as the CCAS scale (CCAS-S). The objective of this research is to prove and contrast the usefulness of the CCAS-S and the Montreal Cognitive Assessment (MoCA) test to evaluate cognitive/affective impairments in patients with chronic acquired cerebellar lesions, and to map the cerebellar areas whose lesions correlated with dysfunctions in these tests. CCAS-S and MoCA were administrated to 22 patients with isolated chronic cerebellar strokes and a matched comparison group. The neural bases underpinning both tests were explored with multivariate lesion-symptom mapping (LSM) methods. MoCA and CCAS-S had an adequate test performance with efficient discrimination between patients and healthy volunteers. However, only impairments determined by the CCAS-S resulted in significant regional localization within the cerebellum. Specifically, patients with chronic cerebellar lesions in right-lateralized posterolateral regions manifested cognitive impairments inherent to CCAS. These findings concurred with the anterior-sensorimotor/posterior-cognitive dichotomy in the human cerebellum and revealed clinically intra- and cross-lobular significant regions (portions of right lobule VI, VII, Crus I-II) for verbal tasks that overlap with the \"language\" functional boundaries in the cerebellum. Our findings prove the usefulness of MoCA and CCAS-S to reveal cognitive impairments in patients with chronic acquired cerebellar lesions. This study extends the understanding of long-term CCAS and introduces multivariate LSM methods to identify clinically intra- and cross-lobular significant regions underpinning chronic CCAS.},\n\tlanguage = {eng},\n\tjournal = {Cerebellum (London, England)},\n\tauthor = {Chirino-Pérez, Amanda and Marrufo-Meléndez, Oscar René and Muñoz-López, José Ignacio and Hernandez-Castillo, Carlos R. and Ramirez-Garcia, Gabriel and Díaz, Rosalinda and Nuñez-Orozco, Lilia and Fernandez-Ruiz, Juan},\n\tmonth = jun,\n\tyear = {2021},\n\tpmid = {34109552},\n\tkeywords = {Cerebellar cognitive affective syndrome, Cerebellar cognitive affective syndrome scale, Cerebellar stroke, Lesion-symptom mapping, Magnetic resonance imaging},\n}\n\n\n\n\n\n\n\n","author_short":["Chirino-Pérez, A.","Marrufo-Meléndez, O. R.","Muñoz-López, J. I.","Hernandez-Castillo, C. R.","Ramirez-Garcia, G.","Díaz, R.","Nuñez-Orozco, L.","Fernandez-Ruiz, J."],"key":"chirino-perez_mapping_2021","id":"chirino-perez_mapping_2021","bibbaseid":"chirinoprez-marrufomelndez-muozlpez-hernandezcastillo-ramirezgarcia-daz-nuezorozco-fernandezruiz-mappingthecerebellarcognitiveaffectivesyndromeinpatientswithchroniccerebellarstrokes-2021","role":"author","urls":{},"keyword":["Cerebellar cognitive affective syndrome","Cerebellar cognitive affective syndrome scale","Cerebellar stroke","Lesion-symptom mapping","Magnetic resonance imaging"],"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/lconcha","dataSources":["vCGHbq7YMoL4xbgTv"],"keywords":["cerebellar cognitive affective syndrome","cerebellar cognitive affective syndrome scale","cerebellar stroke","lesion-symptom mapping","magnetic resonance imaging"],"search_terms":["mapping","cerebellar","cognitive","affective","syndrome","patients","chronic","cerebellar","strokes","chirino-pérez","marrufo-meléndez","muñoz-lópez","hernandez-castillo","ramirez-garcia","díaz","nuñez-orozco","fernandez-ruiz"],"title":"Mapping the Cerebellar Cognitive Affective Syndrome in Patients with Chronic Cerebellar Strokes","year":2021}