Enantioselective Mixed Matrix Membranes for Chiral Resolution. Choi, H., Ahn, Y., & Koh, D. Membranes, 11(4):279, Multidisciplinary Digital Publishing Institute, April, 2021. ![Enantioselective Mixed Matrix Membranes for Chiral Resolution [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Most pharmaceuticals are stereoisomers that each enantiomer shows dramatically different biological activity. Therefore, the production of optically pure chemicals through sustainable and energy-efficient technology is one of the main objectives in the pharmaceutical industry. Membrane-based separation is a continuous process performed on a large scale that uses far less energy than the conventional thermal separation process. Enantioselective polymer membranes have been developed for chiral resolution of pharmaceuticals; however, it is difficult to generate sufficient enantiomeric excess (ee) with conventional polymers. This article describes a chiral resolution strategy using a composite structure of mixed matrix membrane that employs chiral fillers. We discuss several enantioselective fillers, including metal-organic frameworks (MOFs), covalent organic frameworks (COFs), zeolites, porous organic cages (POCs), and their potential use as chiral fillers in mixed matrix membranes. State-of-the-art enantioselective mixed matrix membranes (MMMs) and the future design consideration for highly efficient enantioselective MMMs are discussed.
@article{choi_enantioselective_2021,
title = {Enantioselective {Mixed} {Matrix} {Membranes} for {Chiral} {Resolution}},
volume = {11},
copyright = {http://creativecommons.org/licenses/by/3.0/},
issn = {2077-0375},
url = {https://www.mdpi.com/2077-0375/11/4/279},
doi = {10.3390/membranes11040279},
abstract = {Most pharmaceuticals are stereoisomers that each enantiomer shows dramatically different biological activity. Therefore, the production of optically pure chemicals through sustainable and energy-efficient technology is one of the main objectives in the pharmaceutical industry. Membrane-based separation is a continuous process performed on a large scale that uses far less energy than the conventional thermal separation process. Enantioselective polymer membranes have been developed for chiral resolution of pharmaceuticals; however, it is difficult to generate sufficient enantiomeric excess (ee) with conventional polymers. This article describes a chiral resolution strategy using a composite structure of mixed matrix membrane that employs chiral fillers. We discuss several enantioselective fillers, including metal-organic frameworks (MOFs), covalent organic frameworks (COFs), zeolites, porous organic cages (POCs), and their potential use as chiral fillers in mixed matrix membranes. State-of-the-art enantioselective mixed matrix membranes (MMMs) and the future design consideration for highly efficient enantioselective MMMs are discussed.},
language = {en},
number = {4},
urldate = {2026-01-27},
journal = {Membranes},
publisher = {Multidisciplinary Digital Publishing Institute},
author = {Choi, Hwa-Jin and Ahn, Yun-Ho and Koh, Dong-Yeun},
month = apr,
year = {2021},
keywords = {chiral resolution, diffusion, enantioselective process, molecular interaction, racemic mixture},
pages = {279},
}
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