Hue selectivity from recurrent circuitry in Drosophila. Christenson, M. P., Sanz Diez, A., Heath, S. L., Saavedra-Weisenhaus, M., Adachi, A., Nern, A., Abbott, L. F., & Behnia, R. Nature Neuroscience, 27(6):1137–1147, June, 2024. Publisher: Nature Publishing Group![Hue selectivity from recurrent circuitry in Drosophila [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex In the perception of color, wavelengths of light reflected off objects are transformed into the derived quantities of brightness, saturation and hue. Neurons responding selectively to hue have been reported in primate cortex, but it is unknown how their narrow tuning in color space is produced by upstream circuit mechanisms. We report the discovery of neurons in the Drosophila optic lobe with hue-selective properties, which enables circuit-level analysis of color processing. From our analysis of an electron microscopy volume of a whole Drosophila brain, we construct a connectomics-constrained circuit model that accounts for this hue selectivity. Our model predicts that recurrent connections in the circuit are critical for generating hue selectivity. Experiments using genetic manipulations to perturb recurrence in adult flies confirm this prediction. Our findings reveal a circuit basis for hue selectivity in color vision.
@article{christenson_hue_2024,
title = {Hue selectivity from recurrent circuitry in {Drosophila}},
volume = {27},
copyright = {2024 The Author(s)},
issn = {1546-1726},
url = {https://www.nature.com/articles/s41593-024-01640-4},
doi = {10.1038/s41593-024-01640-4},
abstract = {In the perception of color, wavelengths of light reflected off objects are transformed into the derived quantities of brightness, saturation and hue. Neurons responding selectively to hue have been reported in primate cortex, but it is unknown how their narrow tuning in color space is produced by upstream circuit mechanisms. We report the discovery of neurons in the Drosophila optic lobe with hue-selective properties, which enables circuit-level analysis of color processing. From our analysis of an electron microscopy volume of a whole Drosophila brain, we construct a connectomics-constrained circuit model that accounts for this hue selectivity. Our model predicts that recurrent connections in the circuit are critical for generating hue selectivity. Experiments using genetic manipulations to perturb recurrence in adult flies confirm this prediction. Our findings reveal a circuit basis for hue selectivity in color vision.},
language = {en},
number = {6},
urldate = {2024-12-11},
journal = {Nature Neuroscience},
author = {Christenson, Matthias P. and Sanz Diez, Alvaro and Heath, Sarah L. and Saavedra-Weisenhaus, Maia and Adachi, Atsuko and Nern, Aljoscha and Abbott, L. F. and Behnia, Rudy},
month = jun,
year = {2024},
note = {Publisher: Nature Publishing Group},
keywords = {Neural circuits, Sensory processing},
pages = {1137--1147},
}
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