@ARTICLE{Christopher-Hayes2021-qq,
  title     = "Cannabis use impacts pre-stimulus neural activity in the visual
               cortices of people with {HIV}",
  author    = "Christopher-Hayes, Nicholas J and Lew, Brandon J and Wiesman,
               Alex I and Schantell, Mikki and O'Neill, Jennifer and May,
               Pamela E and Swindells, Susan and Wilson, Tony W",
  abstract  = "People with HIV (PWH) use cannabis at a higher rate than the
               general population, but the influence on neural activity is not
               well characterized. Cannabis use among PWH may have a beneficial
               effect, as neuroinflammation is known to be a critical problem
               in PWH and cannabis use has been associated with a reduction in
               proinflammatory markers. Thus, it is important to understand the
               net impact of cannabis use on brain and cognitive function in
               PWH. In this study, we collected magnetoencephalographic (MEG)
               brain imaging data on 81 participants split across four
               demographically matched groups (i.e., PWH using cannabis,
               controls using cannabis, non-using PWH, and non-using controls).
               Participants completed a visuospatial processing task during
               MEG. Time-frequency resolved voxel time series were extracted to
               identify the dynamics of oscillatory and pre-stimulus baseline
               neural activity. Our results indicated strong theta (4-8 Hz),
               alpha (10-16 Hz), and gamma (62-72 Hz) visual oscillations in
               parietal-occipital brain regions across all participants. PWH
               exhibited significant behavioral deficits in visuospatial
               processing, as well as reduced theta oscillations and elevated
               pre-stimulus gamma activity in visual cortices, all of which
               replicate prior work. Strikingly, chronic cannabis use was
               associated with a significant reduction in pre-stimulus gamma
               activity in the visual cortices, such that PWH no longer
               statistically differed from controls. These results provide
               initial evidence that cannabis use may normalize some neural
               aberrations in PWH. This study fills an important gap in
               understanding the impact of cannabis use on brain and cognitive
               function in PWH.",
  journal   = "Hum. Brain Mapp.",
  publisher = "Wiley",
  volume    =  42,
  number    =  16,
  pages     = "5446--5457",
  month     =  nov,
  year      =  2021,
  keywords  = "MEG; gamma; magnetoencephalography; neural oscillations;
               neurocognitive decline; visuospatial processing",
  copyright = "http://creativecommons.org/licenses/by/4.0/",
  language  = "en"
}

{"_id":"iRFSLYNXsrZEesLBx","bibbaseid":"christopherhayes-lew-wiesman-schantell-oneill-may-swindells-wilson-cannabisuseimpactsprestimulusneuralactivityinthevisualcorticesofpeoplewithhiv-2021","author_short":["Christopher-Hayes, N. J","Lew, B. J","Wiesman, A. I","Schantell, M.","O'Neill, J.","May, P. E","Swindells, S.","Wilson, T. W"],"bibdata":{"bibtype":"article","type":"article","title":"Cannabis use impacts pre-stimulus neural activity in the visual cortices of people with HIV","author":[{"propositions":[],"lastnames":["Christopher-Hayes"],"firstnames":["Nicholas","J"],"suffixes":[]},{"propositions":[],"lastnames":["Lew"],"firstnames":["Brandon","J"],"suffixes":[]},{"propositions":[],"lastnames":["Wiesman"],"firstnames":["Alex","I"],"suffixes":[]},{"propositions":[],"lastnames":["Schantell"],"firstnames":["Mikki"],"suffixes":[]},{"propositions":[],"lastnames":["O'Neill"],"firstnames":["Jennifer"],"suffixes":[]},{"propositions":[],"lastnames":["May"],"firstnames":["Pamela","E"],"suffixes":[]},{"propositions":[],"lastnames":["Swindells"],"firstnames":["Susan"],"suffixes":[]},{"propositions":[],"lastnames":["Wilson"],"firstnames":["Tony","W"],"suffixes":[]}],"abstract":"People with HIV (PWH) use cannabis at a higher rate than the general population, but the influence on neural activity is not well characterized. Cannabis use among PWH may have a beneficial effect, as neuroinflammation is known to be a critical problem in PWH and cannabis use has been associated with a reduction in proinflammatory markers. Thus, it is important to understand the net impact of cannabis use on brain and cognitive function in PWH. In this study, we collected magnetoencephalographic (MEG) brain imaging data on 81 participants split across four demographically matched groups (i.e., PWH using cannabis, controls using cannabis, non-using PWH, and non-using controls). Participants completed a visuospatial processing task during MEG. Time-frequency resolved voxel time series were extracted to identify the dynamics of oscillatory and pre-stimulus baseline neural activity. Our results indicated strong theta (4-8 Hz), alpha (10-16 Hz), and gamma (62-72 Hz) visual oscillations in parietal-occipital brain regions across all participants. PWH exhibited significant behavioral deficits in visuospatial processing, as well as reduced theta oscillations and elevated pre-stimulus gamma activity in visual cortices, all of which replicate prior work. Strikingly, chronic cannabis use was associated with a significant reduction in pre-stimulus gamma activity in the visual cortices, such that PWH no longer statistically differed from controls. These results provide initial evidence that cannabis use may normalize some neural aberrations in PWH. This study fills an important gap in understanding the impact of cannabis use on brain and cognitive function in PWH.","journal":"Hum. Brain Mapp.","publisher":"Wiley","volume":"42","number":"16","pages":"5446–5457","month":"November","year":"2021","keywords":"MEG; gamma; magnetoencephalography; neural oscillations; neurocognitive decline; visuospatial processing","copyright":"http://creativecommons.org/licenses/by/4.0/","language":"en","bibtex":"@ARTICLE{Christopher-Hayes2021-qq,\n title = \"Cannabis use impacts pre-stimulus neural activity in the visual\n cortices of people with {HIV}\",\n author = \"Christopher-Hayes, Nicholas J and Lew, Brandon J and Wiesman,\n Alex I and Schantell, Mikki and O'Neill, Jennifer and May,\n Pamela E and Swindells, Susan and Wilson, Tony W\",\n abstract = \"People with HIV (PWH) use cannabis at a higher rate than the\n general population, but the influence on neural activity is not\n well characterized. Cannabis use among PWH may have a beneficial\n effect, as neuroinflammation is known to be a critical problem\n in PWH and cannabis use has been associated with a reduction in\n proinflammatory markers. Thus, it is important to understand the\n net impact of cannabis use on brain and cognitive function in\n PWH. In this study, we collected magnetoencephalographic (MEG)\n brain imaging data on 81 participants split across four\n demographically matched groups (i.e., PWH using cannabis,\n controls using cannabis, non-using PWH, and non-using controls).\n Participants completed a visuospatial processing task during\n MEG. Time-frequency resolved voxel time series were extracted to\n identify the dynamics of oscillatory and pre-stimulus baseline\n neural activity. Our results indicated strong theta (4-8 Hz),\n alpha (10-16 Hz), and gamma (62-72 Hz) visual oscillations in\n parietal-occipital brain regions across all participants. PWH\n exhibited significant behavioral deficits in visuospatial\n processing, as well as reduced theta oscillations and elevated\n pre-stimulus gamma activity in visual cortices, all of which\n replicate prior work. Strikingly, chronic cannabis use was\n associated with a significant reduction in pre-stimulus gamma\n activity in the visual cortices, such that PWH no longer\n statistically differed from controls. These results provide\n initial evidence that cannabis use may normalize some neural\n aberrations in PWH. This study fills an important gap in\n understanding the impact of cannabis use on brain and cognitive\n function in PWH.\",\n journal = \"Hum. Brain Mapp.\",\n publisher = \"Wiley\",\n volume = 42,\n number = 16,\n pages = \"5446--5457\",\n month = nov,\n year = 2021,\n keywords = \"MEG; gamma; magnetoencephalography; neural oscillations;\n neurocognitive decline; visuospatial processing\",\n copyright = \"http://creativecommons.org/licenses/by/4.0/\",\n language = \"en\"\n}\n\n","author_short":["Christopher-Hayes, N. J","Lew, B. J","Wiesman, A. I","Schantell, M.","O'Neill, J.","May, P. E","Swindells, S.","Wilson, T. W"],"key":"Christopher-Hayes2021-qq","id":"Christopher-Hayes2021-qq","bibbaseid":"christopherhayes-lew-wiesman-schantell-oneill-may-swindells-wilson-cannabisuseimpactsprestimulusneuralactivityinthevisualcorticesofpeoplewithhiv-2021","role":"author","urls":{},"keyword":["MEG; gamma; magnetoencephalography; neural oscillations; neurocognitive decline; visuospatial processing"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/W6vwbf4ertiLCtXrk","dataSources":["EETXeSjnWjvu8vXCY","Sapepnxx7AJvCQiud","TS9e8yQGWurr5225H","pFRMx3nk2qrTi5kxq","PFwSn5dmPaCej5Xuh","tp2Gh66i8ogAEWWRe"],"keywords":["meg; gamma; magnetoencephalography; neural oscillations; neurocognitive decline; visuospatial processing"],"search_terms":["cannabis","use","impacts","pre","stimulus","neural","activity","visual","cortices","people","hiv","christopher-hayes","lew","wiesman","schantell","o'neill","may","swindells","wilson"],"title":"Cannabis use impacts pre-stimulus neural activity in the visual cortices of people with HIV","year":2021}