A Randomized Controlled Trial of a Text Messaging Intervention to Promote Virologic Suppression and Retention in Care in an Urban Safety-Net HIV Clinic: The Connect4Care (C4C) Trial. Christopoulos, K. A., Riley, E. D., Carrico, A. W., Tulsky, J., Moskowitz, J. T., Dilworth, S., Coffin, L. S., Wilson, L., Peretz, J. J., & Hilton, J. F. Clinical Infectious Diseases, February, 2018. ![A Randomized Controlled Trial of a Text Messaging Intervention to Promote Virologic Suppression and Retention in Care in an Urban Safety-Net HIV Clinic: The Connect4Care (C4C) Trial [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex BackgroundText messaging is a promising strategy to support HIV care engagement, but little is known about its efficacy in urban safety-net HIV clinic populations.MethodsWe conducted a randomized controlled trial of a supportive and motivational text messaging intervention, Connect4Care (C4C), among viremic patients who had a history of poor retention or were new to clinic. Participants were randomized (stratified by new HIV diagnosis status) to receive one of the following for 12 months: 1) thrice-weekly intervention messages, plus texted primary care appointment reminders and a monthly text message requesting confirmation of study participation, or; 2) texted reminders and monthly messages alone. Viral load was assessed at 6 and 12 months. The primary outcome was virologic suppression (<200 copies/mL) at 12 months, estimated via repeated measures log-binomial regression, adjusted for new diagnosis status. The secondary outcome was retention in clinic care.ResultsBetween August 2013-November 2015, 230 participants were randomized. Virologic suppression at 12 months was similar between intervention and control participants (48.8% vs. 45.8%), with negligible change from 6-month estimates, yielding RR 1.07 (95% CI: 0.82, 1.39). Suppression was higher in the newly diagnosed (78.3% vs. 45.3%). There were no intervention effects on the secondary outcome. Exploratory analyses suggested that patients with more responses to study text messages had better outcomes, regardless of arm.ConclusionsThe C4C text messaging intervention did not significantly increase virologic suppression or retention in care. Response to text messages may be a useful way for providers to gauge risk for poor HIV outcomes.Clinical Trials RegistrationNCT01917994
@article{christopoulos_randomized_2018,
title = {A {Randomized} {Controlled} {Trial} of a {Text} {Messaging} {Intervention} to {Promote} {Virologic} {Suppression} and {Retention} in {Care} in an {Urban} {Safety}-{Net} {HIV} {Clinic}: {The} {Connect4Care} ({C4C}) {Trial}},
shorttitle = {A {Randomized} {Controlled} {Trial} of a {Text} {Messaging} {Intervention} to {Promote} {Virologic} {Suppression} and {Retention} in {Care} in an {Urban} {Safety}-{Net} {HIV} {Clinic}},
url = {https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciy156/4883333},
doi = {10.1093/cid/ciy156},
abstract = {BackgroundText messaging is a promising strategy to support HIV care engagement, but little is known about its efficacy in urban safety-net HIV clinic populations.MethodsWe conducted a randomized controlled trial of a supportive and motivational text messaging intervention, Connect4Care (C4C), among viremic patients who had a history of poor retention or were new to clinic. Participants were randomized (stratified by new HIV diagnosis status) to receive one of the following for 12 months: 1) thrice-weekly intervention messages, plus texted primary care appointment reminders and a monthly text message requesting confirmation of study participation, or; 2) texted reminders and monthly messages alone. Viral load was assessed at 6 and 12 months. The primary outcome was virologic suppression (\<200 copies/mL) at 12 months, estimated via repeated measures log-binomial regression, adjusted for new diagnosis status. The secondary outcome was retention in clinic care.ResultsBetween August 2013-November 2015, 230 participants were randomized. Virologic suppression at 12 months was similar between intervention and control participants (48.8\% vs. 45.8\%), with negligible change from 6-month estimates, yielding RR 1.07 (95\% CI: 0.82, 1.39). Suppression was higher in the newly diagnosed (78.3\% vs. 45.3\%). There were no intervention effects on the secondary outcome. Exploratory analyses suggested that patients with more responses to study text messages had better outcomes, regardless of arm.ConclusionsThe C4C text messaging intervention did not significantly increase virologic suppression or retention in care. Response to text messages may be a useful way for providers to gauge risk for poor HIV outcomes.Clinical Trials RegistrationNCT01917994},
language = {en},
urldate = {2018-03-19},
journal = {Clinical Infectious Diseases},
author = {Christopoulos, Katerina A. and Riley, Elise D. and Carrico, Adam W. and Tulsky, Jacqueline and Moskowitz, Judith T. and Dilworth, Samantha and Coffin, Lara S. and Wilson, Leslie and Peretz, Jason Johnson and Hilton, Joan F.},
month = feb,
year = {2018}
}
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F."],"bibdata":{"bibtype":"article","type":"article","title":"A Randomized Controlled Trial of a Text Messaging Intervention to Promote Virologic Suppression and Retention in Care in an Urban Safety-Net HIV Clinic: The Connect4Care (C4C) Trial","shorttitle":"A Randomized Controlled Trial of a Text Messaging Intervention to Promote Virologic Suppression and Retention in Care in an Urban Safety-Net HIV Clinic","url":"https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciy156/4883333","doi":"10.1093/cid/ciy156","abstract":"BackgroundText messaging is a promising strategy to support HIV care engagement, but little is known about its efficacy in urban safety-net HIV clinic populations.MethodsWe conducted a randomized controlled trial of a supportive and motivational text messaging intervention, Connect4Care (C4C), among viremic patients who had a history of poor retention or were new to clinic. Participants were randomized (stratified by new HIV diagnosis status) to receive one of the following for 12 months: 1) thrice-weekly intervention messages, plus texted primary care appointment reminders and a monthly text message requesting confirmation of study participation, or; 2) texted reminders and monthly messages alone. Viral load was assessed at 6 and 12 months. The primary outcome was virologic suppression (<200 copies/mL) at 12 months, estimated via repeated measures log-binomial regression, adjusted for new diagnosis status. The secondary outcome was retention in clinic care.ResultsBetween August 2013-November 2015, 230 participants were randomized. Virologic suppression at 12 months was similar between intervention and control participants (48.8% vs. 45.8%), with negligible change from 6-month estimates, yielding RR 1.07 (95% CI: 0.82, 1.39). Suppression was higher in the newly diagnosed (78.3% vs. 45.3%). There were no intervention effects on the secondary outcome. Exploratory analyses suggested that patients with more responses to study text messages had better outcomes, regardless of arm.ConclusionsThe C4C text messaging intervention did not significantly increase virologic suppression or retention in care. Response to text messages may be a useful way for providers to gauge risk for poor HIV outcomes.Clinical Trials RegistrationNCT01917994","language":"en","urldate":"2018-03-19","journal":"Clinical Infectious Diseases","author":[{"propositions":[],"lastnames":["Christopoulos"],"firstnames":["Katerina","A."],"suffixes":[]},{"propositions":[],"lastnames":["Riley"],"firstnames":["Elise","D."],"suffixes":[]},{"propositions":[],"lastnames":["Carrico"],"firstnames":["Adam","W."],"suffixes":[]},{"propositions":[],"lastnames":["Tulsky"],"firstnames":["Jacqueline"],"suffixes":[]},{"propositions":[],"lastnames":["Moskowitz"],"firstnames":["Judith","T."],"suffixes":[]},{"propositions":[],"lastnames":["Dilworth"],"firstnames":["Samantha"],"suffixes":[]},{"propositions":[],"lastnames":["Coffin"],"firstnames":["Lara","S."],"suffixes":[]},{"propositions":[],"lastnames":["Wilson"],"firstnames":["Leslie"],"suffixes":[]},{"propositions":[],"lastnames":["Peretz"],"firstnames":["Jason","Johnson"],"suffixes":[]},{"propositions":[],"lastnames":["Hilton"],"firstnames":["Joan","F."],"suffixes":[]}],"month":"February","year":"2018","bibtex":"@article{christopoulos_randomized_2018,\n\ttitle = {A {Randomized} {Controlled} {Trial} of a {Text} {Messaging} {Intervention} to {Promote} {Virologic} {Suppression} and {Retention} in {Care} in an {Urban} {Safety}-{Net} {HIV} {Clinic}: {The} {Connect4Care} ({C4C}) {Trial}},\n\tshorttitle = {A {Randomized} {Controlled} {Trial} of a {Text} {Messaging} {Intervention} to {Promote} {Virologic} {Suppression} and {Retention} in {Care} in an {Urban} {Safety}-{Net} {HIV} {Clinic}},\n\turl = {https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciy156/4883333},\n\tdoi = {10.1093/cid/ciy156},\n\tabstract = {BackgroundText messaging is a promising strategy to support HIV care engagement, but little is known about its efficacy in urban safety-net HIV clinic populations.MethodsWe conducted a randomized controlled trial of a supportive and motivational text messaging intervention, Connect4Care (C4C), among viremic patients who had a history of poor retention or were new to clinic. Participants were randomized (stratified by new HIV diagnosis status) to receive one of the following for 12 months: 1) thrice-weekly intervention messages, plus texted primary care appointment reminders and a monthly text message requesting confirmation of study participation, or; 2) texted reminders and monthly messages alone. Viral load was assessed at 6 and 12 months. The primary outcome was virologic suppression (\\<200 copies/mL) at 12 months, estimated via repeated measures log-binomial regression, adjusted for new diagnosis status. The secondary outcome was retention in clinic care.ResultsBetween August 2013-November 2015, 230 participants were randomized. Virologic suppression at 12 months was similar between intervention and control participants (48.8\\% vs. 45.8\\%), with negligible change from 6-month estimates, yielding RR 1.07 (95\\% CI: 0.82, 1.39). Suppression was higher in the newly diagnosed (78.3\\% vs. 45.3\\%). There were no intervention effects on the secondary outcome. Exploratory analyses suggested that patients with more responses to study text messages had better outcomes, regardless of arm.ConclusionsThe C4C text messaging intervention did not significantly increase virologic suppression or retention in care. Response to text messages may be a useful way for providers to gauge risk for poor HIV outcomes.Clinical Trials RegistrationNCT01917994},\n\tlanguage = {en},\n\turldate = {2018-03-19},\n\tjournal = {Clinical Infectious Diseases},\n\tauthor = {Christopoulos, Katerina A. and Riley, Elise D. and Carrico, Adam W. and Tulsky, Jacqueline and Moskowitz, Judith T. and Dilworth, Samantha and Coffin, Lara S. and Wilson, Leslie and Peretz, Jason Johnson and Hilton, Joan F.},\n\tmonth = feb,\n\tyear = {2018}\n}\n\n","author_short":["Christopoulos, K. A.","Riley, E. D.","Carrico, A. W.","Tulsky, J.","Moskowitz, J. T.","Dilworth, S.","Coffin, L. S.","Wilson, L.","Peretz, J. J.","Hilton, J. 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