Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study. Chu, H., Chan, J. F., Yuen, T. T., Shuai, H., Yuan, S., Wang, Y., Hu, B., Yip, C. C., Tsang, J. O., Huang, X., Chai, Y., Yang, D., Hou, Y., Chik, K. K., Zhang, X., Fung, A. Y., Tsoi, H., Cai, J., Chan, W., Ip, J. D., Chu, A. W., Zhou, J., Lung, D. C., Kok, K., To, K. K., Tsang, O. T., Chan, K., & Yuen, K. The Lancet Microbe. Publisher: Elsevier![Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted from person to person and, in 2 months, has caused more than 82?000 laboratory-confirmed cases of coronavirus disease 2019 (COVID-19) and 2800 deaths in 46 countries. The total number of cases and deaths has surpassed that of the 2003 severe acute respiratory syndrome coronavirus (SARS-CoV). Although both COVID-19 and severe acute respiratory syndrome (SARS) manifest as pneumonia, COVID-19 is associated with apparently more efficient transmission, fewer cases of diarrhoea, increased mental confusion, and a lower crude fatality rate. However, the underlying virus?host interactive characteristics conferring these observations on transmissibility and clinical manifestations of COVID-19 remain unknown.
@article{chu_comparative_nodate,
title = {Comparative tropism, replication kinetics, and cell damage profiling of {SARS}-{CoV}-2 and {SARS}-{CoV} with implications for clinical manifestations, transmissibility, and laboratory studies of {COVID}-19: an observational study},
issn = {2666-5247},
url = {https://doi.org/10.1016/S2666-5247(20)30004-5},
doi = {10.1016/S2666-5247(20)30004-5},
abstract = {BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted from person to person and, in 2 months, has caused more than 82?000 laboratory-confirmed cases of coronavirus disease 2019 (COVID-19) and 2800 deaths in 46 countries. The total number of cases and deaths has surpassed that of the 2003 severe acute respiratory syndrome coronavirus (SARS-CoV). Although both COVID-19 and severe acute respiratory syndrome (SARS) manifest as pneumonia, COVID-19 is associated with apparently more efficient transmission, fewer cases of diarrhoea, increased mental confusion, and a lower crude fatality rate. However, the underlying virus?host interactive characteristics conferring these observations on transmissibility and clinical manifestations of COVID-19 remain unknown.},
urldate = {2020-04-23},
journal = {The Lancet Microbe},
author = {Chu, Hin and Chan, Jasper Fuk-Woo and Yuen, Terrence Tsz-Tai and Shuai, Huiping and Yuan, Shuofeng and Wang, Yixin and Hu, Bingjie and Yip, Cyril Chik-Yan and Tsang, Jessica Oi-Ling and Huang, Xiner and Chai, Yue and Yang, Dong and Hou, Yuxin and Chik, Kenn Ka-Heng and Zhang, Xi and Fung, Agnes Yim-Fong and Tsoi, Hoi-Wah and Cai, Jian-Piao and Chan, Wan-Mui and Ip, Jonathan Daniel and Chu, Allen Wing-Ho and Zhou, Jie and Lung, David Christopher and Kok, Kin-Hang and To, Kelvin Kai-Wang and Tsang, Owen Tak-Yin and Chan, Kwok-Hung and Yuen, Kwok-Yung},
note = {Publisher: Elsevier},
keywords = {COVID-19, Phylogenetic analysis, RT-PCR, cell damage, cellular susceptibility, replication kinetics, statistical analysis},
}
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T.","Chan, K.","Yuen, K."],"bibdata":{"bibtype":"article","type":"article","title":"Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study","issn":"2666-5247","url":"https://doi.org/10.1016/S2666-5247(20)30004-5","doi":"10.1016/S2666-5247(20)30004-5","abstract":"BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted from person to person and, in 2 months, has caused more than 82?000 laboratory-confirmed cases of coronavirus disease 2019 (COVID-19) and 2800 deaths in 46 countries. The total number of cases and deaths has surpassed that of the 2003 severe acute respiratory syndrome coronavirus (SARS-CoV). 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However, the underlying virus?host interactive characteristics conferring these observations on transmissibility and clinical manifestations of COVID-19 remain unknown.","urldate":"2020-04-23","journal":"The Lancet Microbe","author":[{"propositions":[],"lastnames":["Chu"],"firstnames":["Hin"],"suffixes":[]},{"propositions":[],"lastnames":["Chan"],"firstnames":["Jasper","Fuk-Woo"],"suffixes":[]},{"propositions":[],"lastnames":["Yuen"],"firstnames":["Terrence","Tsz-Tai"],"suffixes":[]},{"propositions":[],"lastnames":["Shuai"],"firstnames":["Huiping"],"suffixes":[]},{"propositions":[],"lastnames":["Yuan"],"firstnames":["Shuofeng"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Yixin"],"suffixes":[]},{"propositions":[],"lastnames":["Hu"],"firstnames":["Bingjie"],"suffixes":[]},{"propositions":[],"lastnames":["Yip"],"firstnames":["Cyril","Chik-Yan"],"suffixes":[]},{"propositions":[],"lastnames":["Tsang"],"firstnames":["Jessica","Oi-Ling"],"suffixes":[]},{"propositions":[],"lastnames":["Huang"],"firstnames":["Xiner"],"suffixes":[]},{"propositions":[],"lastnames":["Chai"],"firstnames":["Yue"],"suffixes":[]},{"propositions":[],"lastnames":["Yang"],"firstnames":["Dong"],"suffixes":[]},{"propositions":[],"lastnames":["Hou"],"firstnames":["Yuxin"],"suffixes":[]},{"propositions":[],"lastnames":["Chik"],"firstnames":["Kenn","Ka-Heng"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Xi"],"suffixes":[]},{"propositions":[],"lastnames":["Fung"],"firstnames":["Agnes","Yim-Fong"],"suffixes":[]},{"propositions":[],"lastnames":["Tsoi"],"firstnames":["Hoi-Wah"],"suffixes":[]},{"propositions":[],"lastnames":["Cai"],"firstnames":["Jian-Piao"],"suffixes":[]},{"propositions":[],"lastnames":["Chan"],"firstnames":["Wan-Mui"],"suffixes":[]},{"propositions":[],"lastnames":["Ip"],"firstnames":["Jonathan","Daniel"],"suffixes":[]},{"propositions":[],"lastnames":["Chu"],"firstnames":["Allen","Wing-Ho"],"suffixes":[]},{"propositions":[],"lastnames":["Zhou"],"firstnames":["Jie"],"suffixes":[]},{"propositions":[],"lastnames":["Lung"],"firstnames":["David","Christopher"],"suffixes":[]},{"propositions":[],"lastnames":["Kok"],"firstnames":["Kin-Hang"],"suffixes":[]},{"propositions":[],"lastnames":["To"],"firstnames":["Kelvin","Kai-Wang"],"suffixes":[]},{"propositions":[],"lastnames":["Tsang"],"firstnames":["Owen","Tak-Yin"],"suffixes":[]},{"propositions":[],"lastnames":["Chan"],"firstnames":["Kwok-Hung"],"suffixes":[]},{"propositions":[],"lastnames":["Yuen"],"firstnames":["Kwok-Yung"],"suffixes":[]}],"note":"Publisher: Elsevier","keywords":"COVID-19, Phylogenetic analysis, RT-PCR, cell damage, cellular susceptibility, replication kinetics, statistical analysis","bibtex":"@article{chu_comparative_nodate,\n\ttitle = {Comparative tropism, replication kinetics, and cell damage profiling of {SARS}-{CoV}-2 and {SARS}-{CoV} with implications for clinical manifestations, transmissibility, and laboratory studies of {COVID}-19: an observational study},\n\tissn = {2666-5247},\n\turl = {https://doi.org/10.1016/S2666-5247(20)30004-5},\n\tdoi = {10.1016/S2666-5247(20)30004-5},\n\tabstract = {BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. 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