Adipose tissue stem cells for therapy: An update on the progress of isolation, culture, storage, and clinical application. Chu, D. T., Phuong, T. N. T., Tien, N. L. B., Tran, D. K., Minh, L. B., Thanh, V. V., Anh, P. G., Pham, V. H., & Nga, V. T. Journal of Clinical Medicine, 2019. ![Adipose tissue stem cells for therapy: An update on the progress of isolation, culture, storage, and clinical application [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Adipose tissue stem cells (ASCs), known as multipotent stem cells, are most commonly used in the clinical applications in recent years. Adipose tissues (AT) have the advantage in the harvesting, isolation, and expansion of ASCs, especially an abundant amount of stem cells compared to bone marrow. ASCs can be found in stromal vascular fractions (SVF) which are easily obtained from the dissociation of adipose tissue. Both SVFs and culture-expanded ASCs exhibit the stem cell characteristics such as differentiation into multiple cell types, regeneration, and immune regulators. Therefore, SVFs and ASCs have been researched to evaluate the safety and benefits for human use. In fact, the number of clinical trials on ASCs is going to increase by years; however, most trials are in phase I and II, and lack phase III and IV. This systemic review highlights and updates the process of the harvesting, characteristics, isolation, culture, storage, and application of ASCs, as well as provides further directions on the therapeutic use of ASCs.
@article{Van_Huy_Pham_76157355,
title = {Adipose tissue stem cells for therapy: {An} update on the progress of isolation, culture, storage, and clinical application},
volume = {8},
issn = {20770383},
url = {http://doi.org/10.3390/JCM8070917},
doi = {10.3390/jcm8070917},
abstract = {Adipose tissue stem cells (ASCs), known as multipotent stem cells, are most commonly used in the clinical applications in recent years. Adipose tissues (AT) have the advantage in the harvesting, isolation, and expansion of ASCs, especially an abundant amount of stem cells compared to bone marrow. ASCs can be found in stromal vascular fractions (SVF) which are easily obtained from the dissociation of adipose tissue. Both SVFs and culture-expanded ASCs exhibit the stem cell characteristics such as differentiation into multiple cell types, regeneration, and immune regulators. Therefore, SVFs and ASCs have been researched to evaluate the safety and benefits for human use. In fact, the number of clinical trials on ASCs is going to increase by years; however, most trials are in phase I and II, and lack phase III and IV. This systemic review highlights and updates the process of the harvesting, characteristics, isolation, culture, storage, and application of ASCs, as well as provides further directions on the therapeutic use of ASCs.},
number = {7},
journal = {Journal of Clinical Medicine},
author = {Chu, Dinh Toi and Phuong, Thuy Nguyen Thi and Tien, Nguyen Le Bao and Tran, Dang Khoa and Minh, Le Bui and Thanh, Vo Van and Anh, Pham Gia and Pham, Van Huy and Nga, Vu Thi},
year = {2019},
keywords = {Adipose tissue stem cells, Clinical application, Culture, Isolation, Stem cell therapy, Storage},
}
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ASCs can be found in stromal vascular fractions (SVF) which are easily obtained from the dissociation of adipose tissue. Both SVFs and culture-expanded ASCs exhibit the stem cell characteristics such as differentiation into multiple cell types, regeneration, and immune regulators. Therefore, SVFs and ASCs have been researched to evaluate the safety and benefits for human use. In fact, the number of clinical trials on ASCs is going to increase by years; however, most trials are in phase I and II, and lack phase III and IV. 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