Action of dopamine as inhibitory neuromodulator in jellyfish synapse

Action of dopamine as inhibitory neuromodulator in jellyfish synapse. Chung, J. & Spencer, A. N. Journal of Biochemistry and Molecular Biology, 31(3):264–268, May, 1998.

Paper abstract bibtex

Dopamine (DA) acts on swimming motor neurons (SMNs) of Polyorchis penicillatus as an inhibitory neurotransmitter by hyperpolarizing their membrane potentials? which results from the activation of voltage-sensitive potassium channels mediated through a D-2-type receptor. In addition, DA, and not the hyperpolarized membrane potential, directly decreased the input resistance of SMNs by ca. 50% from 1.42 to 0.68 G Ohm. It strongly indicates that DA can shunt other excitatory synaptic signals onto SMNs where DA usually elicited much greater responses in their neurites than soma, All these evidences suggest that DA may operate in this primitive nervous system in dual modes as an inhibitory neurotransmitter and neuromodulator as well.

@article{chung_action_1998,
	title = {Action of dopamine as inhibitory neuromodulator in jellyfish synapse},
	volume = {31},
	shorttitle = {Action of dopamine as inhibitory neuromodulator in jellyfish synapse},
	url = {https://astp.jst.go.jp/modules/search/DocumentDetail/0368-4881+%2540+1225-8687+%2540+1976-6696+%2540+_31_3_Action+of+Dopamine+as+Inhibitory+Neuromodulator+in+Jellyfish+Synapse_N%252FA},
	abstract = {Dopamine (DA) acts on swimming motor neurons (SMNs) of Polyorchis penicillatus as an inhibitory neurotransmitter by hyperpolarizing their membrane potentials? which results from the activation of voltage-sensitive potassium channels mediated through a D-2-type receptor. In addition, DA, and not the hyperpolarized membrane potential, directly decreased the input resistance of SMNs by ca. 50\% from 1.42 to 0.68 G Ohm. It strongly indicates that DA can shunt other excitatory synaptic signals onto SMNs where DA usually elicited much greater responses in their neurites than soma, All these evidences suggest that DA may operate in this primitive nervous system in dual modes as an inhibitory neurotransmitter and neuromodulator as well.},
	number = {3},
	journal = {Journal of Biochemistry and Molecular Biology},
	author = {Chung, J. and Spencer, A. N.},
	month = may,
	year = {1998},
	keywords = {Polyorchis penicillatus},
	pages = {264--268},
}

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